Community acquired pneumonia among pediatric outpatients in Salvador, Northeast Brazil, with emphasis on the role of pneumococcus

Detalhes bibliográficos
Autor(a) principal: Nascimento-Carvalho,Cristiana M.C.
Data de Publicação: 2001
Outros Autores: Lopes,Antônio A., Gomes,Maria Daniela B.S., Magalhães,Morgana P., Oliveira,Juliana R., Vilas-Boas,Ana Luisa, Ferracuti,Roberta, Brandileone,Maria Cristina C., Guerra,Maria Luiza L.S., Alves,Noraney N., Athayde,Ledilce A., Caldas,Renilza M., Barberino,Maria Goreth M. A., Duarte,Jussara, Brandão,Maria Angélica S., Rocha,Heonir, Benguigui,Yehuda, Di Fabio,José Luis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Infectious Diseases
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000100003
Resumo: Pneumonia is one of the leading causes of hospitalization and death among children in developing countries, and mortality due to pneumonia has been associated with S. pneumoniae infection. This investigation was designed to describe the antimicrobial susceptibility and serotype patterns of pneumococcal strains recovered from the blood of children with community-acquired pneumonia (CAP) and to assess the clinical findings of pneumococcal bacteremic patients with pneumonia. In a 26 month prospective study, blood cultures were obtained as often as possible from children (<16 years of age) diagnosed with CAP in two emergency rooms. Antimicrobial drug susceptibility tests and serotyping were performed when pneumococcus was identified. We studied 3,431 cases and cultured blood samples from 65.5% of those. Pneumococcus was recovered from 0.8% of the blood samples. The differences in age, somnolence, wheezing and hospitalization among children with and without pneumococcal bacteremia were statistically significant. Pneumococcal bacteremia was age-related (mean 1.63 ± 1.55; median 0.92) and associated with somnolence and hospitalization among children with CAP. One strain was recovered from pleural fluid. Penicillin resistance was detected in 21.0% (4/19) of the strains at an intermediate level, whereas 63.0% of the strains were resistant to trimethoprim-sulfamethoxazole. The most common serotypes were 14 and 6B, and these serotypes included the resistant strains. Eight of our 18 isolates from blood were of types included in the heptavalent conjugate pneumococcal vaccine, recently licensed in the USA.
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spelling Community acquired pneumonia among pediatric outpatients in Salvador, Northeast Brazil, with emphasis on the role of pneumococcusStreptococcus pneumoniaeantimicrobial resistanceserotypesblood culturecommunity-acquired pneumoniachildrenPneumonia is one of the leading causes of hospitalization and death among children in developing countries, and mortality due to pneumonia has been associated with S. pneumoniae infection. This investigation was designed to describe the antimicrobial susceptibility and serotype patterns of pneumococcal strains recovered from the blood of children with community-acquired pneumonia (CAP) and to assess the clinical findings of pneumococcal bacteremic patients with pneumonia. In a 26 month prospective study, blood cultures were obtained as often as possible from children (<16 years of age) diagnosed with CAP in two emergency rooms. Antimicrobial drug susceptibility tests and serotyping were performed when pneumococcus was identified. We studied 3,431 cases and cultured blood samples from 65.5% of those. Pneumococcus was recovered from 0.8% of the blood samples. The differences in age, somnolence, wheezing and hospitalization among children with and without pneumococcal bacteremia were statistically significant. Pneumococcal bacteremia was age-related (mean 1.63 ± 1.55; median 0.92) and associated with somnolence and hospitalization among children with CAP. One strain was recovered from pleural fluid. Penicillin resistance was detected in 21.0% (4/19) of the strains at an intermediate level, whereas 63.0% of the strains were resistant to trimethoprim-sulfamethoxazole. The most common serotypes were 14 and 6B, and these serotypes included the resistant strains. Eight of our 18 isolates from blood were of types included in the heptavalent conjugate pneumococcal vaccine, recently licensed in the USA.Brazilian Society of Infectious Diseases2001-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000100003Brazilian Journal of Infectious Diseases v.5 n.1 2001reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1590/S1413-86702001000100003info:eu-repo/semantics/openAccessNascimento-Carvalho,Cristiana M.C.Lopes,Antônio A.Gomes,Maria Daniela B.S.Magalhães,Morgana P.Oliveira,Juliana R.Vilas-Boas,Ana LuisaFerracuti,RobertaBrandileone,Maria Cristina C.Guerra,Maria Luiza L.S.Alves,Noraney N.Athayde,Ledilce A.Caldas,Renilza M.Barberino,Maria Goreth M. A.Duarte,JussaraBrandão,Maria Angélica S.Rocha,HeonirBenguigui,YehudaDi Fabio,José Luiseng2001-10-29T00:00:00Zoai:scielo:S1413-86702001000100003Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2001-10-29T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false
dc.title.none.fl_str_mv Community acquired pneumonia among pediatric outpatients in Salvador, Northeast Brazil, with emphasis on the role of pneumococcus
title Community acquired pneumonia among pediatric outpatients in Salvador, Northeast Brazil, with emphasis on the role of pneumococcus
spellingShingle Community acquired pneumonia among pediatric outpatients in Salvador, Northeast Brazil, with emphasis on the role of pneumococcus
Nascimento-Carvalho,Cristiana M.C.
Streptococcus pneumoniae
antimicrobial resistance
serotypes
blood culture
community-acquired pneumonia
children
title_short Community acquired pneumonia among pediatric outpatients in Salvador, Northeast Brazil, with emphasis on the role of pneumococcus
title_full Community acquired pneumonia among pediatric outpatients in Salvador, Northeast Brazil, with emphasis on the role of pneumococcus
title_fullStr Community acquired pneumonia among pediatric outpatients in Salvador, Northeast Brazil, with emphasis on the role of pneumococcus
title_full_unstemmed Community acquired pneumonia among pediatric outpatients in Salvador, Northeast Brazil, with emphasis on the role of pneumococcus
title_sort Community acquired pneumonia among pediatric outpatients in Salvador, Northeast Brazil, with emphasis on the role of pneumococcus
author Nascimento-Carvalho,Cristiana M.C.
author_facet Nascimento-Carvalho,Cristiana M.C.
Lopes,Antônio A.
Gomes,Maria Daniela B.S.
Magalhães,Morgana P.
Oliveira,Juliana R.
Vilas-Boas,Ana Luisa
Ferracuti,Roberta
Brandileone,Maria Cristina C.
Guerra,Maria Luiza L.S.
Alves,Noraney N.
Athayde,Ledilce A.
Caldas,Renilza M.
Barberino,Maria Goreth M. A.
Duarte,Jussara
Brandão,Maria Angélica S.
Rocha,Heonir
Benguigui,Yehuda
Di Fabio,José Luis
author_role author
author2 Lopes,Antônio A.
Gomes,Maria Daniela B.S.
Magalhães,Morgana P.
Oliveira,Juliana R.
Vilas-Boas,Ana Luisa
Ferracuti,Roberta
Brandileone,Maria Cristina C.
Guerra,Maria Luiza L.S.
Alves,Noraney N.
Athayde,Ledilce A.
Caldas,Renilza M.
Barberino,Maria Goreth M. A.
Duarte,Jussara
Brandão,Maria Angélica S.
Rocha,Heonir
Benguigui,Yehuda
Di Fabio,José Luis
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nascimento-Carvalho,Cristiana M.C.
Lopes,Antônio A.
Gomes,Maria Daniela B.S.
Magalhães,Morgana P.
Oliveira,Juliana R.
Vilas-Boas,Ana Luisa
Ferracuti,Roberta
Brandileone,Maria Cristina C.
Guerra,Maria Luiza L.S.
Alves,Noraney N.
Athayde,Ledilce A.
Caldas,Renilza M.
Barberino,Maria Goreth M. A.
Duarte,Jussara
Brandão,Maria Angélica S.
Rocha,Heonir
Benguigui,Yehuda
Di Fabio,José Luis
dc.subject.por.fl_str_mv Streptococcus pneumoniae
antimicrobial resistance
serotypes
blood culture
community-acquired pneumonia
children
topic Streptococcus pneumoniae
antimicrobial resistance
serotypes
blood culture
community-acquired pneumonia
children
description Pneumonia is one of the leading causes of hospitalization and death among children in developing countries, and mortality due to pneumonia has been associated with S. pneumoniae infection. This investigation was designed to describe the antimicrobial susceptibility and serotype patterns of pneumococcal strains recovered from the blood of children with community-acquired pneumonia (CAP) and to assess the clinical findings of pneumococcal bacteremic patients with pneumonia. In a 26 month prospective study, blood cultures were obtained as often as possible from children (<16 years of age) diagnosed with CAP in two emergency rooms. Antimicrobial drug susceptibility tests and serotyping were performed when pneumococcus was identified. We studied 3,431 cases and cultured blood samples from 65.5% of those. Pneumococcus was recovered from 0.8% of the blood samples. The differences in age, somnolence, wheezing and hospitalization among children with and without pneumococcal bacteremia were statistically significant. Pneumococcal bacteremia was age-related (mean 1.63 ± 1.55; median 0.92) and associated with somnolence and hospitalization among children with CAP. One strain was recovered from pleural fluid. Penicillin resistance was detected in 21.0% (4/19) of the strains at an intermediate level, whereas 63.0% of the strains were resistant to trimethoprim-sulfamethoxazole. The most common serotypes were 14 and 6B, and these serotypes included the resistant strains. Eight of our 18 isolates from blood were of types included in the heptavalent conjugate pneumococcal vaccine, recently licensed in the USA.
publishDate 2001
dc.date.none.fl_str_mv 2001-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000100003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000100003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1413-86702001000100003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv Brazilian Journal of Infectious Diseases v.5 n.1 2001
reponame:Brazilian Journal of Infectious Diseases
instname:Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
instname_str Brazilian Society of Infectious Diseases (BSID)
instacron_str BSID
institution BSID
reponame_str Brazilian Journal of Infectious Diseases
collection Brazilian Journal of Infectious Diseases
repository.name.fl_str_mv Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)
repository.mail.fl_str_mv bjid@bjid.org.br||lgoldani@ufrgs.br
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