Penicillin-resistant pneumococcus and risk of treatment failure in pneumonia

Detalhes bibliográficos
Autor(a) principal: Cardoso, Maria Regina Alves
Data de Publicação: 2008
Outros Autores: Carvalho, Cristiana Maria Costa Nascimento de, Ferrero, Fernando, Berezin, Eitan N., Ruvinsky, Raúl, Camargos, Paulo Augusto Moreira, Sant'Anna, Clemax Couto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/14305
Resumo: Texto completo: acesso restrito. p. 221-225
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spelling Cardoso, Maria Regina AlvesCarvalho, Cristiana Maria Costa Nascimento deFerrero, FernandoBerezin, Eitan N.Ruvinsky, RaúlCamargos, Paulo Augusto MoreiraSant'Anna, Clemax CoutoCardoso, Maria Regina AlvesCarvalho, Cristiana Maria Costa Nascimento deFerrero, FernandoBerezin, Eitan N.Ruvinsky, RaúlCamargos, Paulo Augusto MoreiraSant'Anna, Clemax Couto2014-01-08T18:17:22Z20080003-9888http://repositorio.ufba.br/ri/handle/ri/14305v. 93, n. 3Texto completo: acesso restrito. p. 221-225Objective: To determine whether the presence of in vitro penicillin-resistant Streptococcus pneumoniae increases the risk of clinical failure in children hospitalised with severe pneumonia and treated with penicillin/ampicillin. Design: Multicentre, prospective, observational study. Setting: 12 tertiary-care centres in three countries in Latin America. Patients: 240 children aged 3–59 months, hospitalised with severe pneumonia and known in vitro susceptibility of S pneumoniae. Intervention: Patients were treated with intravenous penicillin/ampicillin after collection of blood and, when possible, pleural fluid for culture. The minimal inhibitory concentration (MIC) test was used to determine penicillin susceptibility of the pneumococcal strains isolated. Children were continuously monitored until discharge. Main outcome measures: The primary outcome was treatment failure (using clinical criteria). Results: Overall treatment failure was 21%. After allowing for different potential confounders, there was no evidence of association between treatment failure and in vitro resistance of S pneumoniae to penicillin according to the Clinical Laboratory Standards Institute (CLSI)/National Committee for Clinical Laboratory Standards (NCCLS) interpretative standards (adjRR = 1.03; 95%CI: 0.49–1.90 for resistant S pneumoniae). Conclusions: Intravenous penicillin/ampicillin remains the drug of choice for treating penicillin-resistant pneumococcal pneumonia in areas where the MIC does not exceed 2 μg/ml.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-12-16T13:38:36Z No. of bitstreams: 1 10.1136adc.2006.111625.pdf: 209859 bytes, checksum: 3121c5d440ba8346aaec52cd9ba0f5d9 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-01-08T18:17:22Z (GMT) No. of bitstreams: 1 10.1136adc.2006.111625.pdf: 209859 bytes, checksum: 3121c5d440ba8346aaec52cd9ba0f5d9 (MD5)Made available in DSpace on 2014-01-08T18:17:22Z (GMT). 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dc.title.pt_BR.fl_str_mv Penicillin-resistant pneumococcus and risk of treatment failure in pneumonia
dc.title.alternative.pt_BR.fl_str_mv Archives of Disease in Childhood
title Penicillin-resistant pneumococcus and risk of treatment failure in pneumonia
spellingShingle Penicillin-resistant pneumococcus and risk of treatment failure in pneumonia
Cardoso, Maria Regina Alves
Ampicillin
Streptococcus pneumoniae
Pneumonia
title_short Penicillin-resistant pneumococcus and risk of treatment failure in pneumonia
title_full Penicillin-resistant pneumococcus and risk of treatment failure in pneumonia
title_fullStr Penicillin-resistant pneumococcus and risk of treatment failure in pneumonia
title_full_unstemmed Penicillin-resistant pneumococcus and risk of treatment failure in pneumonia
title_sort Penicillin-resistant pneumococcus and risk of treatment failure in pneumonia
author Cardoso, Maria Regina Alves
author_facet Cardoso, Maria Regina Alves
Carvalho, Cristiana Maria Costa Nascimento de
Ferrero, Fernando
Berezin, Eitan N.
Ruvinsky, Raúl
Camargos, Paulo Augusto Moreira
Sant'Anna, Clemax Couto
author_role author
author2 Carvalho, Cristiana Maria Costa Nascimento de
Ferrero, Fernando
Berezin, Eitan N.
Ruvinsky, Raúl
Camargos, Paulo Augusto Moreira
Sant'Anna, Clemax Couto
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cardoso, Maria Regina Alves
Carvalho, Cristiana Maria Costa Nascimento de
Ferrero, Fernando
Berezin, Eitan N.
Ruvinsky, Raúl
Camargos, Paulo Augusto Moreira
Sant'Anna, Clemax Couto
Cardoso, Maria Regina Alves
Carvalho, Cristiana Maria Costa Nascimento de
Ferrero, Fernando
Berezin, Eitan N.
Ruvinsky, Raúl
Camargos, Paulo Augusto Moreira
Sant'Anna, Clemax Couto
dc.subject.por.fl_str_mv Ampicillin
Streptococcus pneumoniae
Pneumonia
topic Ampicillin
Streptococcus pneumoniae
Pneumonia
description Texto completo: acesso restrito. p. 221-225
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2014-01-08T18:17:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14305
dc.identifier.issn.none.fl_str_mv 0003-9888
dc.identifier.number.pt_BR.fl_str_mv v. 93, n. 3
identifier_str_mv 0003-9888
v. 93, n. 3
url http://repositorio.ufba.br/ri/handle/ri/14305
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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