Assessment of antioxidants status and superoxide dismutase activity in HIV-infected children
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Infectious Diseases |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500481 |
Resumo: | Objective:This study aims to assess the nutritional status of selenium, copper and zinc; and also the erythrocyte superoxide dismutase activity of HIV-infected children compared to a control group.Methods:A cross-sectional study was carried out with prepubertal HIV-infected children (n = 51) and their healthy siblings (n = 32). All biochemical measurements including plasma selenium, serum copper levels, serum and erythrocyte zinc levels and erythrocyte super-oxide dismutase activity were evaluated according to dietary, clinical and biochemical parameters.Results:Compared to the control group, the HIV-infected children had lower z-score values for height-for-age (p = 0.0006), higher prevalence of stunting (11.8%) (p = 0.047), lower selenium levels (p = 0.0006) and higher copper levels (p = 0.019). No difference was found concerning superoxide dismutase activity (p > 0.05). The HIV-infected group presented a higher proportion (45.1%) of children with zinc intakes below the estimated average requirement (p = 0.014); however, no association with zinc biochemical parameters was found.Conclusion:HIV-infected children have an inadequate selenium and copper nutritional status, which could influence the progression to AIDS. An adequate micronutrient status could improve the clinical conditions in these patients and minimize free radical production and cellular oxidative stress. |
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Brazilian Journal of Infectious Diseases |
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Assessment of antioxidants status and superoxide dismutase activity in HIV-infected childrenAntioxidantsHIV and nutritionOxidative stressTrace elementsObjective:This study aims to assess the nutritional status of selenium, copper and zinc; and also the erythrocyte superoxide dismutase activity of HIV-infected children compared to a control group.Methods:A cross-sectional study was carried out with prepubertal HIV-infected children (n = 51) and their healthy siblings (n = 32). All biochemical measurements including plasma selenium, serum copper levels, serum and erythrocyte zinc levels and erythrocyte super-oxide dismutase activity were evaluated according to dietary, clinical and biochemical parameters.Results:Compared to the control group, the HIV-infected children had lower z-score values for height-for-age (p = 0.0006), higher prevalence of stunting (11.8%) (p = 0.047), lower selenium levels (p = 0.0006) and higher copper levels (p = 0.019). No difference was found concerning superoxide dismutase activity (p > 0.05). The HIV-infected group presented a higher proportion (45.1%) of children with zinc intakes below the estimated average requirement (p = 0.014); however, no association with zinc biochemical parameters was found.Conclusion:HIV-infected children have an inadequate selenium and copper nutritional status, which could influence the progression to AIDS. An adequate micronutrient status could improve the clinical conditions in these patients and minimize free radical production and cellular oxidative stress.Brazilian Society of Infectious Diseases2014-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500481Brazilian Journal of Infectious Diseases v.18 n.5 2014reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1016/j.bjid.2014.02.003info:eu-repo/semantics/openAccessPugliese,CamilaPatin,Rose VegaPalchetti,Cecilia ZaninClaudio,Cristiane ChiantelliGouvêa,Aída de Fátima Thomé BarbosaSucci,Regina Célia de MenezesAmancio,Olga Maria SilverioCozzolino,Silvia Maria FranciscatoOliveira,Fernanda Luisa Ceragiolieng2015-09-01T00:00:00Zoai:scielo:S1413-86702014000500481Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2015-09-01T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false |
dc.title.none.fl_str_mv |
Assessment of antioxidants status and superoxide dismutase activity in HIV-infected children |
title |
Assessment of antioxidants status and superoxide dismutase activity in HIV-infected children |
spellingShingle |
Assessment of antioxidants status and superoxide dismutase activity in HIV-infected children Pugliese,Camila Antioxidants HIV and nutrition Oxidative stress Trace elements |
title_short |
Assessment of antioxidants status and superoxide dismutase activity in HIV-infected children |
title_full |
Assessment of antioxidants status and superoxide dismutase activity in HIV-infected children |
title_fullStr |
Assessment of antioxidants status and superoxide dismutase activity in HIV-infected children |
title_full_unstemmed |
Assessment of antioxidants status and superoxide dismutase activity in HIV-infected children |
title_sort |
Assessment of antioxidants status and superoxide dismutase activity in HIV-infected children |
author |
Pugliese,Camila |
author_facet |
Pugliese,Camila Patin,Rose Vega Palchetti,Cecilia Zanin Claudio,Cristiane Chiantelli Gouvêa,Aída de Fátima Thomé Barbosa Succi,Regina Célia de Menezes Amancio,Olga Maria Silverio Cozzolino,Silvia Maria Franciscato Oliveira,Fernanda Luisa Ceragioli |
author_role |
author |
author2 |
Patin,Rose Vega Palchetti,Cecilia Zanin Claudio,Cristiane Chiantelli Gouvêa,Aída de Fátima Thomé Barbosa Succi,Regina Célia de Menezes Amancio,Olga Maria Silverio Cozzolino,Silvia Maria Franciscato Oliveira,Fernanda Luisa Ceragioli |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Pugliese,Camila Patin,Rose Vega Palchetti,Cecilia Zanin Claudio,Cristiane Chiantelli Gouvêa,Aída de Fátima Thomé Barbosa Succi,Regina Célia de Menezes Amancio,Olga Maria Silverio Cozzolino,Silvia Maria Franciscato Oliveira,Fernanda Luisa Ceragioli |
dc.subject.por.fl_str_mv |
Antioxidants HIV and nutrition Oxidative stress Trace elements |
topic |
Antioxidants HIV and nutrition Oxidative stress Trace elements |
description |
Objective:This study aims to assess the nutritional status of selenium, copper and zinc; and also the erythrocyte superoxide dismutase activity of HIV-infected children compared to a control group.Methods:A cross-sectional study was carried out with prepubertal HIV-infected children (n = 51) and their healthy siblings (n = 32). All biochemical measurements including plasma selenium, serum copper levels, serum and erythrocyte zinc levels and erythrocyte super-oxide dismutase activity were evaluated according to dietary, clinical and biochemical parameters.Results:Compared to the control group, the HIV-infected children had lower z-score values for height-for-age (p = 0.0006), higher prevalence of stunting (11.8%) (p = 0.047), lower selenium levels (p = 0.0006) and higher copper levels (p = 0.019). No difference was found concerning superoxide dismutase activity (p > 0.05). The HIV-infected group presented a higher proportion (45.1%) of children with zinc intakes below the estimated average requirement (p = 0.014); however, no association with zinc biochemical parameters was found.Conclusion:HIV-infected children have an inadequate selenium and copper nutritional status, which could influence the progression to AIDS. An adequate micronutrient status could improve the clinical conditions in these patients and minimize free radical production and cellular oxidative stress. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500481 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500481 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjid.2014.02.003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
Brazilian Journal of Infectious Diseases v.18 n.5 2014 reponame:Brazilian Journal of Infectious Diseases instname:Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
instname_str |
Brazilian Society of Infectious Diseases (BSID) |
instacron_str |
BSID |
institution |
BSID |
reponame_str |
Brazilian Journal of Infectious Diseases |
collection |
Brazilian Journal of Infectious Diseases |
repository.name.fl_str_mv |
Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID) |
repository.mail.fl_str_mv |
bjid@bjid.org.br||lgoldani@ufrgs.br |
_version_ |
1754209243185020928 |