Renal involvement in leptospirosis: new insights into pathophysiology and treatment
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Infectious Diseases |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300016 |
Resumo: | Acute renal failure (ARF) is one of the most common complications of leptospirosis although the causal mechanisms are still unclear. Diverse mechanisms are implicated in leptospiral nephropathy and new data supports the role of peculiar ion transport defects. Besides antibiotic therapy, ARF management in leptospirosis requires dialytic therapy which is most efficient when started early. Dialysis is the standard supportive therapy even though recent evidence suggests clinical benefit from alternative treatments such as plasmapheresis and hemofiltration. Renal recovery is achieved soon after clinical improvement. The comprehension of the primary mechanisms of renal dysfunction will be helpful in the development of additional therapeutic tools for improving supportive therapy for leptospiral nephropathy. This review discusses new insights into mechanisms implicated in leptospiral ARF and recent advances in treatment. |
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Brazilian Journal of Infectious Diseases |
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Renal involvement in leptospirosis: new insights into pathophysiology and treatmentLeptospirosiskidney failureacutephysiopathologydialysisAcute renal failure (ARF) is one of the most common complications of leptospirosis although the causal mechanisms are still unclear. Diverse mechanisms are implicated in leptospiral nephropathy and new data supports the role of peculiar ion transport defects. Besides antibiotic therapy, ARF management in leptospirosis requires dialytic therapy which is most efficient when started early. Dialysis is the standard supportive therapy even though recent evidence suggests clinical benefit from alternative treatments such as plasmapheresis and hemofiltration. Renal recovery is achieved soon after clinical improvement. The comprehension of the primary mechanisms of renal dysfunction will be helpful in the development of additional therapeutic tools for improving supportive therapy for leptospiral nephropathy. This review discusses new insights into mechanisms implicated in leptospiral ARF and recent advances in treatment.Brazilian Society of Infectious Diseases2008-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300016Brazilian Journal of Infectious Diseases v.12 n.3 2008reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1590/S1413-86702008000300016info:eu-repo/semantics/openAccessCerqueira,Thaís BandeiraAthanazio,Daniel AbensurSpichler,Anne StambovskySeguro,Antônio Carloseng2008-09-24T00:00:00Zoai:scielo:S1413-86702008000300016Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2008-09-24T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false |
dc.title.none.fl_str_mv |
Renal involvement in leptospirosis: new insights into pathophysiology and treatment |
title |
Renal involvement in leptospirosis: new insights into pathophysiology and treatment |
spellingShingle |
Renal involvement in leptospirosis: new insights into pathophysiology and treatment Cerqueira,Thaís Bandeira Leptospirosis kidney failure acute physiopathology dialysis |
title_short |
Renal involvement in leptospirosis: new insights into pathophysiology and treatment |
title_full |
Renal involvement in leptospirosis: new insights into pathophysiology and treatment |
title_fullStr |
Renal involvement in leptospirosis: new insights into pathophysiology and treatment |
title_full_unstemmed |
Renal involvement in leptospirosis: new insights into pathophysiology and treatment |
title_sort |
Renal involvement in leptospirosis: new insights into pathophysiology and treatment |
author |
Cerqueira,Thaís Bandeira |
author_facet |
Cerqueira,Thaís Bandeira Athanazio,Daniel Abensur Spichler,Anne Stambovsky Seguro,Antônio Carlos |
author_role |
author |
author2 |
Athanazio,Daniel Abensur Spichler,Anne Stambovsky Seguro,Antônio Carlos |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Cerqueira,Thaís Bandeira Athanazio,Daniel Abensur Spichler,Anne Stambovsky Seguro,Antônio Carlos |
dc.subject.por.fl_str_mv |
Leptospirosis kidney failure acute physiopathology dialysis |
topic |
Leptospirosis kidney failure acute physiopathology dialysis |
description |
Acute renal failure (ARF) is one of the most common complications of leptospirosis although the causal mechanisms are still unclear. Diverse mechanisms are implicated in leptospiral nephropathy and new data supports the role of peculiar ion transport defects. Besides antibiotic therapy, ARF management in leptospirosis requires dialytic therapy which is most efficient when started early. Dialysis is the standard supportive therapy even though recent evidence suggests clinical benefit from alternative treatments such as plasmapheresis and hemofiltration. Renal recovery is achieved soon after clinical improvement. The comprehension of the primary mechanisms of renal dysfunction will be helpful in the development of additional therapeutic tools for improving supportive therapy for leptospiral nephropathy. This review discusses new insights into mechanisms implicated in leptospiral ARF and recent advances in treatment. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300016 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1413-86702008000300016 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
Brazilian Journal of Infectious Diseases v.12 n.3 2008 reponame:Brazilian Journal of Infectious Diseases instname:Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
instname_str |
Brazilian Society of Infectious Diseases (BSID) |
instacron_str |
BSID |
institution |
BSID |
reponame_str |
Brazilian Journal of Infectious Diseases |
collection |
Brazilian Journal of Infectious Diseases |
repository.name.fl_str_mv |
Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID) |
repository.mail.fl_str_mv |
bjid@bjid.org.br||lgoldani@ufrgs.br |
_version_ |
1754209240303534080 |