Organizing pneumonia: A late phase complication of COVID-19 responding dramatically to corticosteroids

• Autor(a) principal: de Oliveira Filho,Cilomar Martins
• Data de Publicação: 2021
• Outros Autores: Vieceli,Tarsila, de Fraga Bassotto,Caroline, da Rosa Barbato,João Pedro, Garcia,Tiago Severo, Scheffel,Rafael Selbach
• Tipo de documento: Relatório
• Idioma: eng
• Título da fonte: Brazilian Journal of Infectious Diseases
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702021000100400
• topic: COVID-19; Organizing pneumonia; Corticosteroids

ABSTRACT Organizing pneumonia emerges as a late phase complication of COVID-19. Corticosteroids are standard therapy for organizing pneumonia, but the question of whether an approach with high dose corticosteroids would be beneficial for patients with organizing pneumonia secondary to COVID-19 remains to be answered.Herein we report a series of three patients, one male and two females, mean age 58.3 years old, admitted for COVID-19 with severe pulmonary disease requiring ventilatory support. The patients underwent chest computed tomography scans due to maintained hypoxemia, which showed a pattern compatible with organizing pneumonia. The patients were treated with a high dose of corticosteroids (prednisone 1 mg/kg PO), showing marked clinical improvement, and decreasing oxygen flow ratio demand. They were discharged after a mean period of 6.3 days of hospitalization.Our report suggests that patients with COVID-19 with organizing pneumonia might benefit from high dose corticosteroids as an adjuvant therapy.