Acute HIV infection with rapid progression to AIDS

Detalhes bibliográficos
Autor(a) principal: Silva,Marcio de Oliveira
Data de Publicação: 2010
Outros Autores: Bastos,Milena, Martins Netto,Eduardo, Gouvea,Nancy Alves de Lima, Torres,Alex Jose Leite, Kallas,Esper, Watkins,David I, Altfeld,Marcus, Brites,Carlos
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Brazilian Journal of Infectious Diseases
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300016
Resumo: Acute HIV infection is rarely recognized as the signs and symptoms are normally unspecific and can persist for days or weeks. The normal HIV course is characterized by a progressive loss of CD4+ cells, which normally leads to severe immunodeficiency after a variable time interval. The mean time from initial infection to development of clinical AIDS is approximately 8-10 years, but it is variable among individuals and depends on a complex interaction between virus and host. Here we describe an extraordinary case of a man who developed Pneumocisits jiroveci pneumonia within one month after sexual exposure to HIV-1, and then presented with 3 consecutive CD4 counts bellow 200 cells/mm³ within 3 months, with no other opportunistic disease. Although antiretroviral therapy (AZT+3TC+ATZ/r) was started, with full adherence of the patient, and genotyping indicating no primary antiretroviral resistance mutations, he required more than six months to have a CD4 restoration to levels above 200 cells/mm³ and 10 months to HIV-RNA to become undetectable.
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spelling Acute HIV infection with rapid progression to AIDSHIVacute infectionprogressionAIDSAcute HIV infection is rarely recognized as the signs and symptoms are normally unspecific and can persist for days or weeks. The normal HIV course is characterized by a progressive loss of CD4+ cells, which normally leads to severe immunodeficiency after a variable time interval. The mean time from initial infection to development of clinical AIDS is approximately 8-10 years, but it is variable among individuals and depends on a complex interaction between virus and host. Here we describe an extraordinary case of a man who developed Pneumocisits jiroveci pneumonia within one month after sexual exposure to HIV-1, and then presented with 3 consecutive CD4 counts bellow 200 cells/mm³ within 3 months, with no other opportunistic disease. Although antiretroviral therapy (AZT+3TC+ATZ/r) was started, with full adherence of the patient, and genotyping indicating no primary antiretroviral resistance mutations, he required more than six months to have a CD4 restoration to levels above 200 cells/mm³ and 10 months to HIV-RNA to become undetectable.Brazilian Society of Infectious Diseases2010-06-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300016Brazilian Journal of Infectious Diseases v.14 n.3 2010reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1590/S1413-86702010000300016info:eu-repo/semantics/openAccessSilva,Marcio de OliveiraBastos,MilenaMartins Netto,EduardoGouvea,Nancy Alves de LimaTorres,Alex Jose LeiteKallas,EsperWatkins,David IAltfeld,MarcusBrites,Carloseng2010-09-03T00:00:00Zoai:scielo:S1413-86702010000300016Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2010-09-03T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false
dc.title.none.fl_str_mv Acute HIV infection with rapid progression to AIDS
title Acute HIV infection with rapid progression to AIDS
spellingShingle Acute HIV infection with rapid progression to AIDS
Silva,Marcio de Oliveira
HIV
acute infection
progression
AIDS
title_short Acute HIV infection with rapid progression to AIDS
title_full Acute HIV infection with rapid progression to AIDS
title_fullStr Acute HIV infection with rapid progression to AIDS
title_full_unstemmed Acute HIV infection with rapid progression to AIDS
title_sort Acute HIV infection with rapid progression to AIDS
author Silva,Marcio de Oliveira
author_facet Silva,Marcio de Oliveira
Bastos,Milena
Martins Netto,Eduardo
Gouvea,Nancy Alves de Lima
Torres,Alex Jose Leite
Kallas,Esper
Watkins,David I
Altfeld,Marcus
Brites,Carlos
author_role author
author2 Bastos,Milena
Martins Netto,Eduardo
Gouvea,Nancy Alves de Lima
Torres,Alex Jose Leite
Kallas,Esper
Watkins,David I
Altfeld,Marcus
Brites,Carlos
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva,Marcio de Oliveira
Bastos,Milena
Martins Netto,Eduardo
Gouvea,Nancy Alves de Lima
Torres,Alex Jose Leite
Kallas,Esper
Watkins,David I
Altfeld,Marcus
Brites,Carlos
dc.subject.por.fl_str_mv HIV
acute infection
progression
AIDS
topic HIV
acute infection
progression
AIDS
description Acute HIV infection is rarely recognized as the signs and symptoms are normally unspecific and can persist for days or weeks. The normal HIV course is characterized by a progressive loss of CD4+ cells, which normally leads to severe immunodeficiency after a variable time interval. The mean time from initial infection to development of clinical AIDS is approximately 8-10 years, but it is variable among individuals and depends on a complex interaction between virus and host. Here we describe an extraordinary case of a man who developed Pneumocisits jiroveci pneumonia within one month after sexual exposure to HIV-1, and then presented with 3 consecutive CD4 counts bellow 200 cells/mm³ within 3 months, with no other opportunistic disease. Although antiretroviral therapy (AZT+3TC+ATZ/r) was started, with full adherence of the patient, and genotyping indicating no primary antiretroviral resistance mutations, he required more than six months to have a CD4 restoration to levels above 200 cells/mm³ and 10 months to HIV-RNA to become undetectable.
publishDate 2010
dc.date.none.fl_str_mv 2010-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1413-86702010000300016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv Brazilian Journal of Infectious Diseases v.14 n.3 2010
reponame:Brazilian Journal of Infectious Diseases
instname:Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
instname_str Brazilian Society of Infectious Diseases (BSID)
instacron_str BSID
institution BSID
reponame_str Brazilian Journal of Infectious Diseases
collection Brazilian Journal of Infectious Diseases
repository.name.fl_str_mv Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)
repository.mail.fl_str_mv bjid@bjid.org.br||lgoldani@ufrgs.br
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