CRF19_cpx is an Evolutionary fit HIV-1 Variant Strongly Associated With Rapid Progression to AIDS in Cuba.

Detalhes bibliográficos
Autor(a) principal: Kouri, Vivian
Data de Publicação: 2015
Outros Autores: Cunha, Antonio Ricardo Khouri, Alemán, Yoan, Abrahantes, Yeissel, Vercauteren, Jurgen, Peña, Andrea Clemencia Pineda, Theys, Kristof, Megens, Sarah, Moutschene, Michel, Pfeifer, Nico, Van Weyenbergh, Johan Jozef Rosa Maria, Pérez, Ana B, Pérez, Jorge, Pérez, Lissette, Van Laethem, Kristel, Vandamme, Anne-Mieke
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11383
Resumo: Institute of Tropical Medicine Pedro Kourí. Virology Department. Autopista Novia del Mediodía. Havana City, Cuba
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spelling Kouri, VivianCunha, Antonio Ricardo KhouriAlemán, YoanAbrahantes, YeisselVercauteren, JurgenPeña, Andrea Clemencia PinedaTheys, KristofMegens, SarahMoutschene, MichelPfeifer, NicoVan Weyenbergh, Johan Jozef Rosa MariaPérez, Ana BPérez, JorgePérez, LissetteVan Laethem, KristelVandamme, Anne-Mieke2015-07-15T18:04:15Z2015-07-15T18:04:15Z2015KOURI, V. et al. CRF19_cpx is an Evolutionary fit HIV-1 Variant Strongly Associated With apid Progression to AIDS in Cuba. EBioMedicine, v. 2, n. 3, p. 244-254, 2015.2352-3964https://www.arca.fiocruz.br/handle/icict/11383dx.doi.org/10.1016/j.ebiom.2015.01.015engElsevierCRF19_cpx is an Evolutionary fit HIV-1 Variant Strongly Associated With Rapid Progression to AIDS in Cuba.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstitute of Tropical Medicine Pedro Kourí. Virology Department. Autopista Novia del Mediodía. Havana City, CubaKU Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Clinical and Epidemiological Virology. Leuven, Belgium / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Laboratório de Imunoparasitologia. Salvador, BA, BrasilInstitute of Tropical Medicine Pedro Kourí. Virology Department. Autopista Novia del Mediodía. Havana City, CubaInstitute of Tropical Medicine Pedro Kourí. Virology Department. Autopista Novia del Mediodía. Havana City, CubaKU Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Clinical and Epidemiological Virology. Leuven, BelgiumKU Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Clinical and Epidemiological Virology. Leuven, Belgium / Universidad del Rosario. Faculty of Sciences and Mathematics. Clinical and Molecular Infectious Diseases Group. Bogotá, ColombiaKU Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Clinical and Epidemiological Virology. Leuven, BelgiumKU Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Clinical and Epidemiological Virology. Leuven, BelgiumCentre Hospitalier Universitaire de Liège. AIDS Reference Center. Liège, BelgiumMax Planck Institute for Informatics. Department of Computational Biology and Applied Algorithmics. Saarbrücken, GermanyKU Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Clinical and Epidemiological Virology. Leuven, BelgiumInstitute of Tropical Medicine Pedro Kourí. Virology Department. Autopista Novia del Mediodía. Havana City, CubaInstitute of Tropical Medicine Pedro Kourí. Virology Department. Autopista Novia del Mediodía. Havana City, CubaInstitute of Tropical Medicine Pedro Kourí. Virology Department. Autopista Novia del Mediodía. Havana City, CubaKU Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Clinical and Epidemiological Virology. Leuven, BelgiumKU Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Clinical and Epidemiological Virology. Leuven, Belgium / Universidade Nova de Lisboa. Instituto de Higiene e Medicina Tropical. Centro de Malária e outras Doenças Tropicais and Unidade de Microbiologia. Lisbon, PortugalBackground: Clinicians reported an increasing trend of rapid progression (RP) (AIDS within 3 years of infection) in Cuba. Methods: Recently infected patientswere prospectively sampled, 52 RP at AIDS diagnosis (AIDS-RP) and 21without AIDS in the same time frame (non-AIDS). 22 patients were sampled at AIDS diagnosis (chronic-AIDS) retrospectively assessed as N3 years infected. Clinical, demographic, virological, epidemiological and immunological data were collected. Pol and env sequenceswere used for subtyping, transmission cluster analysis, and prediction of resistance, co-receptor use and evolutionary fitness. Host, immunological and viral predictors of RP were explored through data mining. Findings: Subtyping revealed 26 subtype B strains, 6 C, 6 CRF18_cpx, 9 CRF19_cpx, 29 BG-recombinants and other subtypes/ URFs. All patients infected with CRF19 belonged to the AIDS-RP group. Data mining identified CRF19, oral candidiasis and RANTES levels as the strongest predictors of AIDS-RP. CRF19 was more frequently predicted to use the CXCR4 co-receptor, had higher fitness scores in the protease region, and patients had higher viral load at diagnosis. Interpretation: CRF19 is a recombinant of subtype D (C-part of Gag, PR, RT and nef), subtype A (N-part of Gag, Integrase, Env) and subtype G (Vif, Vpr, Vpu and C-part of Env). Since subtypes D and A have been associated with respectively faster and slower disease progression, our findings might indicate a fit PR driving high viral load, which in combination with co-infections may boost RANTES levels and thus CXCR4 use, potentially explaining the fast progression. We propose that CRF19 is evolutionary very fit and causing rapid progression to AIDS in many newly infected patients in Cuba.CRF19HIV-1VariantProgression to AIDSCubainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11383/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALKouri V CRF19 cpx is an....pdfKouri V CRF19 cpx is an....pdfapplication/pdf1135859https://www.arca.fiocruz.br/bitstream/icict/11383/2/Kouri%20V%20CRF19%20cpx%20is%20an....pdf4f395ed1eaa2604704ed24f66619b950MD52TEXTKouri V CRF19 cpx is an....pdf.txtKouri V CRF19 cpx is an....pdf.txtExtracted texttext/plain59505https://www.arca.fiocruz.br/bitstream/icict/11383/3/Kouri%20V%20CRF19%20cpx%20is%20an....pdf.txt08a1ca0bd143b8c6e7e6eb191067fccbMD53icict/113832023-03-15 14:33:07.38oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:07Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv CRF19_cpx is an Evolutionary fit HIV-1 Variant Strongly Associated With Rapid Progression to AIDS in Cuba.
title CRF19_cpx is an Evolutionary fit HIV-1 Variant Strongly Associated With Rapid Progression to AIDS in Cuba.
spellingShingle CRF19_cpx is an Evolutionary fit HIV-1 Variant Strongly Associated With Rapid Progression to AIDS in Cuba.
Kouri, Vivian
CRF19
HIV-1
Variant
Progression to AIDS
Cuba
title_short CRF19_cpx is an Evolutionary fit HIV-1 Variant Strongly Associated With Rapid Progression to AIDS in Cuba.
title_full CRF19_cpx is an Evolutionary fit HIV-1 Variant Strongly Associated With Rapid Progression to AIDS in Cuba.
title_fullStr CRF19_cpx is an Evolutionary fit HIV-1 Variant Strongly Associated With Rapid Progression to AIDS in Cuba.
title_full_unstemmed CRF19_cpx is an Evolutionary fit HIV-1 Variant Strongly Associated With Rapid Progression to AIDS in Cuba.
title_sort CRF19_cpx is an Evolutionary fit HIV-1 Variant Strongly Associated With Rapid Progression to AIDS in Cuba.
author Kouri, Vivian
author_facet Kouri, Vivian
Cunha, Antonio Ricardo Khouri
Alemán, Yoan
Abrahantes, Yeissel
Vercauteren, Jurgen
Peña, Andrea Clemencia Pineda
Theys, Kristof
Megens, Sarah
Moutschene, Michel
Pfeifer, Nico
Van Weyenbergh, Johan Jozef Rosa Maria
Pérez, Ana B
Pérez, Jorge
Pérez, Lissette
Van Laethem, Kristel
Vandamme, Anne-Mieke
author_role author
author2 Cunha, Antonio Ricardo Khouri
Alemán, Yoan
Abrahantes, Yeissel
Vercauteren, Jurgen
Peña, Andrea Clemencia Pineda
Theys, Kristof
Megens, Sarah
Moutschene, Michel
Pfeifer, Nico
Van Weyenbergh, Johan Jozef Rosa Maria
Pérez, Ana B
Pérez, Jorge
Pérez, Lissette
Van Laethem, Kristel
Vandamme, Anne-Mieke
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kouri, Vivian
Cunha, Antonio Ricardo Khouri
Alemán, Yoan
Abrahantes, Yeissel
Vercauteren, Jurgen
Peña, Andrea Clemencia Pineda
Theys, Kristof
Megens, Sarah
Moutschene, Michel
Pfeifer, Nico
Van Weyenbergh, Johan Jozef Rosa Maria
Pérez, Ana B
Pérez, Jorge
Pérez, Lissette
Van Laethem, Kristel
Vandamme, Anne-Mieke
dc.subject.en.pt_BR.fl_str_mv CRF19
HIV-1
Variant
Progression to AIDS
Cuba
topic CRF19
HIV-1
Variant
Progression to AIDS
Cuba
description Institute of Tropical Medicine Pedro Kourí. Virology Department. Autopista Novia del Mediodía. Havana City, Cuba
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-07-15T18:04:15Z
dc.date.available.fl_str_mv 2015-07-15T18:04:15Z
dc.date.issued.fl_str_mv 2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv KOURI, V. et al. CRF19_cpx is an Evolutionary fit HIV-1 Variant Strongly Associated With apid Progression to AIDS in Cuba. EBioMedicine, v. 2, n. 3, p. 244-254, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11383
dc.identifier.issn.none.fl_str_mv 2352-3964
dc.identifier.doi.none.fl_str_mv dx.doi.org/10.1016/j.ebiom.2015.01.015
identifier_str_mv KOURI, V. et al. CRF19_cpx is an Evolutionary fit HIV-1 Variant Strongly Associated With apid Progression to AIDS in Cuba. EBioMedicine, v. 2, n. 3, p. 244-254, 2015.
2352-3964
dx.doi.org/10.1016/j.ebiom.2015.01.015
url https://www.arca.fiocruz.br/handle/icict/11383
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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