Immunohistochemical evaluation for P53 and VEGF (Vascular Endothelial Growth Factor) is not prognostic for long term survival in end stage esophageal adenocarcinoma

Detalhes bibliográficos
Autor(a) principal: Cavazzola,Leandro Totti
Data de Publicação: 2009
Outros Autores: Rosa,André Ricardo Pereira da, Schirmer,Carlos Cauduro, Gurski,Richard Ricachenevski, Telles,João Pedro Bueno, Mielke,Fernando, Meurer,Luíse, Edelweiss,Maria Isabel Albano, Kruel,Cleber Dario Pinto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Colégio Brasileiro de Cirurgiões
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912009000100007
Resumo: OBJECTIVES: To correlate the expression of p53 protein and VEGF with the prognosis of patients submitted to curative resection to treat esophageal adenocarcinoma. METHODS: Forty-six patients with esophageal adenocarcinoma, submitted to curative resection, were studied. The expressions of p53 protein and VEGF were assessed by immunohistochemistry in 52.2% and 47.8% of tumors, respectively. RESULTS: P53 protein and VEGF expressions coincided in 26% of the cases, and no correlation between these expressions was observed. None of the clinicopathological factors showed a significant correlation with p53 protein or VEGF expressions. There was no significant association between p53 protein and VEGF expressions and long-term survival. CONCLUSION: The expression of p53 protein and VEGF did not correlate with prognosis in esophageal adenocarcinoma patients submitted to curative resection.
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spelling Immunohistochemical evaluation for P53 and VEGF (Vascular Endothelial Growth Factor) is not prognostic for long term survival in end stage esophageal adenocarcinomaEsophageal neoplasmsPrognosisGenes p53Vascular endothelial growth factor ASurvivorshipOBJECTIVES: To correlate the expression of p53 protein and VEGF with the prognosis of patients submitted to curative resection to treat esophageal adenocarcinoma. METHODS: Forty-six patients with esophageal adenocarcinoma, submitted to curative resection, were studied. The expressions of p53 protein and VEGF were assessed by immunohistochemistry in 52.2% and 47.8% of tumors, respectively. RESULTS: P53 protein and VEGF expressions coincided in 26% of the cases, and no correlation between these expressions was observed. None of the clinicopathological factors showed a significant correlation with p53 protein or VEGF expressions. There was no significant association between p53 protein and VEGF expressions and long-term survival. CONCLUSION: The expression of p53 protein and VEGF did not correlate with prognosis in esophageal adenocarcinoma patients submitted to curative resection.Colégio Brasileiro de Cirurgiões2009-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912009000100007Revista do Colégio Brasileiro de Cirurgiões v.36 n.1 2009reponame:Revista do Colégio Brasileiro de Cirurgiõesinstname:Colégio Brasileiro de Cirurgiões (CBC)instacron:CBC10.1590/S0100-69912009000100007info:eu-repo/semantics/openAccessCavazzola,Leandro TottiRosa,André Ricardo Pereira daSchirmer,Carlos CauduroGurski,Richard RicachenevskiTelles,João Pedro BuenoMielke,FernandoMeurer,LuíseEdelweiss,Maria Isabel AlbanoKruel,Cleber Dario Pintoeng2009-05-19T00:00:00Zoai:scielo:S0100-69912009000100007Revistahttp://www.scielo.br/rcbcONGhttps://old.scielo.br/oai/scielo-oai.php||revistacbc@cbc.org.br1809-45460100-6991opendoar:2009-05-19T00:00Revista do Colégio Brasileiro de Cirurgiões - Colégio Brasileiro de Cirurgiões (CBC)false
dc.title.none.fl_str_mv Immunohistochemical evaluation for P53 and VEGF (Vascular Endothelial Growth Factor) is not prognostic for long term survival in end stage esophageal adenocarcinoma
title Immunohistochemical evaluation for P53 and VEGF (Vascular Endothelial Growth Factor) is not prognostic for long term survival in end stage esophageal adenocarcinoma
spellingShingle Immunohistochemical evaluation for P53 and VEGF (Vascular Endothelial Growth Factor) is not prognostic for long term survival in end stage esophageal adenocarcinoma
Cavazzola,Leandro Totti
Esophageal neoplasms
Prognosis
Genes p53
Vascular endothelial growth factor A
Survivorship
title_short Immunohistochemical evaluation for P53 and VEGF (Vascular Endothelial Growth Factor) is not prognostic for long term survival in end stage esophageal adenocarcinoma
title_full Immunohistochemical evaluation for P53 and VEGF (Vascular Endothelial Growth Factor) is not prognostic for long term survival in end stage esophageal adenocarcinoma
title_fullStr Immunohistochemical evaluation for P53 and VEGF (Vascular Endothelial Growth Factor) is not prognostic for long term survival in end stage esophageal adenocarcinoma
title_full_unstemmed Immunohistochemical evaluation for P53 and VEGF (Vascular Endothelial Growth Factor) is not prognostic for long term survival in end stage esophageal adenocarcinoma
title_sort Immunohistochemical evaluation for P53 and VEGF (Vascular Endothelial Growth Factor) is not prognostic for long term survival in end stage esophageal adenocarcinoma
author Cavazzola,Leandro Totti
author_facet Cavazzola,Leandro Totti
Rosa,André Ricardo Pereira da
Schirmer,Carlos Cauduro
Gurski,Richard Ricachenevski
Telles,João Pedro Bueno
Mielke,Fernando
Meurer,Luíse
Edelweiss,Maria Isabel Albano
Kruel,Cleber Dario Pinto
author_role author
author2 Rosa,André Ricardo Pereira da
Schirmer,Carlos Cauduro
Gurski,Richard Ricachenevski
Telles,João Pedro Bueno
Mielke,Fernando
Meurer,Luíse
Edelweiss,Maria Isabel Albano
Kruel,Cleber Dario Pinto
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cavazzola,Leandro Totti
Rosa,André Ricardo Pereira da
Schirmer,Carlos Cauduro
Gurski,Richard Ricachenevski
Telles,João Pedro Bueno
Mielke,Fernando
Meurer,Luíse
Edelweiss,Maria Isabel Albano
Kruel,Cleber Dario Pinto
dc.subject.por.fl_str_mv Esophageal neoplasms
Prognosis
Genes p53
Vascular endothelial growth factor A
Survivorship
topic Esophageal neoplasms
Prognosis
Genes p53
Vascular endothelial growth factor A
Survivorship
description OBJECTIVES: To correlate the expression of p53 protein and VEGF with the prognosis of patients submitted to curative resection to treat esophageal adenocarcinoma. METHODS: Forty-six patients with esophageal adenocarcinoma, submitted to curative resection, were studied. The expressions of p53 protein and VEGF were assessed by immunohistochemistry in 52.2% and 47.8% of tumors, respectively. RESULTS: P53 protein and VEGF expressions coincided in 26% of the cases, and no correlation between these expressions was observed. None of the clinicopathological factors showed a significant correlation with p53 protein or VEGF expressions. There was no significant association between p53 protein and VEGF expressions and long-term survival. CONCLUSION: The expression of p53 protein and VEGF did not correlate with prognosis in esophageal adenocarcinoma patients submitted to curative resection.
publishDate 2009
dc.date.none.fl_str_mv 2009-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912009000100007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912009000100007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-69912009000100007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Colégio Brasileiro de Cirurgiões
publisher.none.fl_str_mv Colégio Brasileiro de Cirurgiões
dc.source.none.fl_str_mv Revista do Colégio Brasileiro de Cirurgiões v.36 n.1 2009
reponame:Revista do Colégio Brasileiro de Cirurgiões
instname:Colégio Brasileiro de Cirurgiões (CBC)
instacron:CBC
instname_str Colégio Brasileiro de Cirurgiões (CBC)
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institution CBC
reponame_str Revista do Colégio Brasileiro de Cirurgiões
collection Revista do Colégio Brasileiro de Cirurgiões
repository.name.fl_str_mv Revista do Colégio Brasileiro de Cirurgiões - Colégio Brasileiro de Cirurgiões (CBC)
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