Impact of neoadjuvant therapy in downstaging of lower rectal adenocarcinoma and the role of pelvic magnetic resonance in staging

Detalhes bibliográficos
Autor(a) principal: Magri,Karina Dagre
Data de Publicação: 2016
Outros Autores: Bin,Fang Chia, Formiga,Fernanda Bellotti, Manzione,Thiago da Silveira, Gomes,Caroline Merci Caliari de Neves, Candelári,Paulo de Azeredo Passos, Ortiz,Jorge Alberto, Klug,Wilmar Artur, Mandia Neto,José, Capelhuchnik,Peretz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Colégio Brasileiro de Cirurgiões
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912016000200102
Resumo: ABSTRACT Objective: to evaluate the effect of neoadjuvant therapy on the stage (TNM) of patients with rectal adenocarcinoma and validate the use of MRI as a method of determining locoregional stage. Methods: we conducted a retrospective study of 157 patients with lower rectum adenocarcinoma, whom we divided into two groups: Group 1, 81 patients (52%) who had undergone surgical treatment initially, with the purpose to analyze the accuracy of locoregional staging by pelvic magnetic resonance imaging throug the comparison of radiological findings with pathological ones; Group 2, 76 patients (48%), who had been submitted to neoadjuvant therapy (chemotherapy and radiation) prior to definitive surgical treatment, so as to evaluate its effects on the stage by comparing clinical and radiological findings with pathology. Results: In group 1, the accuracy of determining tumor depth (T) and lymph node involvement (N) was 91.4% and 82.7%, respectively. In group 2, neoadjuvant therapy decreased the T stage, N stage and TNM stage in 51.3%, 21% and 48.4% of cases, respectively. Conclusion: neoadjuvant therapy in patients with rectal adenocarcinoma is effective in decreasing disease stage, and pelvic magnetic resonance imaging is effective for locoregional staging.
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spelling Impact of neoadjuvant therapy in downstaging of lower rectal adenocarcinoma and the role of pelvic magnetic resonance in stagingAdenocarcinomaRectal NeoplasmsNeoadjuvant TherapyMagnetic Resonance ImagingNeoplasm Staging.ABSTRACT Objective: to evaluate the effect of neoadjuvant therapy on the stage (TNM) of patients with rectal adenocarcinoma and validate the use of MRI as a method of determining locoregional stage. Methods: we conducted a retrospective study of 157 patients with lower rectum adenocarcinoma, whom we divided into two groups: Group 1, 81 patients (52%) who had undergone surgical treatment initially, with the purpose to analyze the accuracy of locoregional staging by pelvic magnetic resonance imaging throug the comparison of radiological findings with pathological ones; Group 2, 76 patients (48%), who had been submitted to neoadjuvant therapy (chemotherapy and radiation) prior to definitive surgical treatment, so as to evaluate its effects on the stage by comparing clinical and radiological findings with pathology. Results: In group 1, the accuracy of determining tumor depth (T) and lymph node involvement (N) was 91.4% and 82.7%, respectively. In group 2, neoadjuvant therapy decreased the T stage, N stage and TNM stage in 51.3%, 21% and 48.4% of cases, respectively. Conclusion: neoadjuvant therapy in patients with rectal adenocarcinoma is effective in decreasing disease stage, and pelvic magnetic resonance imaging is effective for locoregional staging.Colégio Brasileiro de Cirurgiões2016-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912016000200102Revista do Colégio Brasileiro de Cirurgiões v.43 n.2 2016reponame:Revista do Colégio Brasileiro de Cirurgiõesinstname:Colégio Brasileiro de Cirurgiões (CBC)instacron:CBC10.1590/0100-69912016002006info:eu-repo/semantics/openAccessMagri,Karina DagreBin,Fang ChiaFormiga,Fernanda BellottiManzione,Thiago da SilveiraGomes,Caroline Merci Caliari de NevesCandelári,Paulo de Azeredo PassosOrtiz,Jorge AlbertoKlug,Wilmar ArturMandia Neto,JoséCapelhuchnik,Peretzeng2016-05-25T00:00:00Zoai:scielo:S0100-69912016000200102Revistahttp://www.scielo.br/rcbcONGhttps://old.scielo.br/oai/scielo-oai.php||revistacbc@cbc.org.br1809-45460100-6991opendoar:2016-05-25T00:00Revista do Colégio Brasileiro de Cirurgiões - Colégio Brasileiro de Cirurgiões (CBC)false
dc.title.none.fl_str_mv Impact of neoadjuvant therapy in downstaging of lower rectal adenocarcinoma and the role of pelvic magnetic resonance in staging
title Impact of neoadjuvant therapy in downstaging of lower rectal adenocarcinoma and the role of pelvic magnetic resonance in staging
spellingShingle Impact of neoadjuvant therapy in downstaging of lower rectal adenocarcinoma and the role of pelvic magnetic resonance in staging
Magri,Karina Dagre
Adenocarcinoma
Rectal Neoplasms
Neoadjuvant Therapy
Magnetic Resonance Imaging
Neoplasm Staging.
title_short Impact of neoadjuvant therapy in downstaging of lower rectal adenocarcinoma and the role of pelvic magnetic resonance in staging
title_full Impact of neoadjuvant therapy in downstaging of lower rectal adenocarcinoma and the role of pelvic magnetic resonance in staging
title_fullStr Impact of neoadjuvant therapy in downstaging of lower rectal adenocarcinoma and the role of pelvic magnetic resonance in staging
title_full_unstemmed Impact of neoadjuvant therapy in downstaging of lower rectal adenocarcinoma and the role of pelvic magnetic resonance in staging
title_sort Impact of neoadjuvant therapy in downstaging of lower rectal adenocarcinoma and the role of pelvic magnetic resonance in staging
author Magri,Karina Dagre
author_facet Magri,Karina Dagre
Bin,Fang Chia
Formiga,Fernanda Bellotti
Manzione,Thiago da Silveira
Gomes,Caroline Merci Caliari de Neves
Candelári,Paulo de Azeredo Passos
Ortiz,Jorge Alberto
Klug,Wilmar Artur
Mandia Neto,José
Capelhuchnik,Peretz
author_role author
author2 Bin,Fang Chia
Formiga,Fernanda Bellotti
Manzione,Thiago da Silveira
Gomes,Caroline Merci Caliari de Neves
Candelári,Paulo de Azeredo Passos
Ortiz,Jorge Alberto
Klug,Wilmar Artur
Mandia Neto,José
Capelhuchnik,Peretz
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Magri,Karina Dagre
Bin,Fang Chia
Formiga,Fernanda Bellotti
Manzione,Thiago da Silveira
Gomes,Caroline Merci Caliari de Neves
Candelári,Paulo de Azeredo Passos
Ortiz,Jorge Alberto
Klug,Wilmar Artur
Mandia Neto,José
Capelhuchnik,Peretz
dc.subject.por.fl_str_mv Adenocarcinoma
Rectal Neoplasms
Neoadjuvant Therapy
Magnetic Resonance Imaging
Neoplasm Staging.
topic Adenocarcinoma
Rectal Neoplasms
Neoadjuvant Therapy
Magnetic Resonance Imaging
Neoplasm Staging.
description ABSTRACT Objective: to evaluate the effect of neoadjuvant therapy on the stage (TNM) of patients with rectal adenocarcinoma and validate the use of MRI as a method of determining locoregional stage. Methods: we conducted a retrospective study of 157 patients with lower rectum adenocarcinoma, whom we divided into two groups: Group 1, 81 patients (52%) who had undergone surgical treatment initially, with the purpose to analyze the accuracy of locoregional staging by pelvic magnetic resonance imaging throug the comparison of radiological findings with pathological ones; Group 2, 76 patients (48%), who had been submitted to neoadjuvant therapy (chemotherapy and radiation) prior to definitive surgical treatment, so as to evaluate its effects on the stage by comparing clinical and radiological findings with pathology. Results: In group 1, the accuracy of determining tumor depth (T) and lymph node involvement (N) was 91.4% and 82.7%, respectively. In group 2, neoadjuvant therapy decreased the T stage, N stage and TNM stage in 51.3%, 21% and 48.4% of cases, respectively. Conclusion: neoadjuvant therapy in patients with rectal adenocarcinoma is effective in decreasing disease stage, and pelvic magnetic resonance imaging is effective for locoregional staging.
publishDate 2016
dc.date.none.fl_str_mv 2016-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/0100-69912016002006
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dc.publisher.none.fl_str_mv Colégio Brasileiro de Cirurgiões
publisher.none.fl_str_mv Colégio Brasileiro de Cirurgiões
dc.source.none.fl_str_mv Revista do Colégio Brasileiro de Cirurgiões v.43 n.2 2016
reponame:Revista do Colégio Brasileiro de Cirurgiões
instname:Colégio Brasileiro de Cirurgiões (CBC)
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reponame_str Revista do Colégio Brasileiro de Cirurgiões
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