Clinical impact of the Model for End Liver Disease (MELD) score on the presence of microvascular invasion and on the postoperative outcome in patients undergoing liver transplantation

Detalhes bibliográficos
Autor(a) principal: BARBOSA,BRAINNER CAMPOS
Data de Publicação: 2021
Outros Autores: SANTOS,LEANDRO AUGUSTO RODRIGUES, DAHER,GUSTAVO HENRIQUE RASSI MAHAMED, MARTINS,DANIEL LAHAN, PERALES,SIMONE REGES, GALLANI,STEPHANIS KILARIS, COSTA,LARISSA BASTOS ELOY DA, LAGO,EDUARDO ANDREAZZA DAL, BOIN,IIKA DE FÁTIMA SANTANTA FERREIRA, CASERTA,NELSON MARCIO GOMES, ATAÍDE,ELAINE CRISTINA DE
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Colégio Brasileiro de Cirurgiões
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912021000100239
Resumo: ABSTRACT Objective: to correlate clinical and epidemiological data with the pathological analysis of liver explants from patients undergoing liver transplantation for hetapocarcinoma in the UNICAMP HC and to verify whether the MELD and MELD-Na scores are reliable factors to predict a worse post-transplant prognosis. Methods: we studied liver transplants carried out between May 2010 and November 2017. After excluding 38 patients, we included 87, analyzing clinical and laboratory data for correlation with the outcome Microvascular Invasion (MVI). Subsequently, we computed the MELD and MELD-Na scores and performed a descriptive analysis of clinical and laboratory data and, finally, calculated ROC curves to assess the association between these laboratory parameters and mortality in these patients. Results: most patients were male (78.30%), with an average age of 58.53 years. Most liver diseases were caused by HCV (53.26%). We found no predictors for MVI among the laboratory parameters. The ROC curves for death identified the MELD score as the cutoff point with the highest combined sensitivity (90.91%) and specificity (37.50%), with a value of 10 points, whereas in the MELD-Na the cutoff point was 7 points, with a sensitivity of 90.91% and a specificity of 33.33%, both scores being significant. Conclusions: there were no reliable predictors of MVI between clinical, laboratory, and epidemiological variables. The MELD-Na score is more sensitive than the MELD one for predicting mortality in patients undergoing liver transplantation.
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spelling Clinical impact of the Model for End Liver Disease (MELD) score on the presence of microvascular invasion and on the postoperative outcome in patients undergoing liver transplantationLiver NeoplasmsHepatic CirrhosisLiver transplantABSTRACT Objective: to correlate clinical and epidemiological data with the pathological analysis of liver explants from patients undergoing liver transplantation for hetapocarcinoma in the UNICAMP HC and to verify whether the MELD and MELD-Na scores are reliable factors to predict a worse post-transplant prognosis. Methods: we studied liver transplants carried out between May 2010 and November 2017. After excluding 38 patients, we included 87, analyzing clinical and laboratory data for correlation with the outcome Microvascular Invasion (MVI). Subsequently, we computed the MELD and MELD-Na scores and performed a descriptive analysis of clinical and laboratory data and, finally, calculated ROC curves to assess the association between these laboratory parameters and mortality in these patients. Results: most patients were male (78.30%), with an average age of 58.53 years. Most liver diseases were caused by HCV (53.26%). We found no predictors for MVI among the laboratory parameters. The ROC curves for death identified the MELD score as the cutoff point with the highest combined sensitivity (90.91%) and specificity (37.50%), with a value of 10 points, whereas in the MELD-Na the cutoff point was 7 points, with a sensitivity of 90.91% and a specificity of 33.33%, both scores being significant. Conclusions: there were no reliable predictors of MVI between clinical, laboratory, and epidemiological variables. The MELD-Na score is more sensitive than the MELD one for predicting mortality in patients undergoing liver transplantation.Colégio Brasileiro de Cirurgiões2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912021000100239Revista do Colégio Brasileiro de Cirurgiões v.48 2021reponame:Revista do Colégio Brasileiro de Cirurgiõesinstname:Colégio Brasileiro de Cirurgiões (CBC)instacron:CBC10.1590/0100-6991e-20212997info:eu-repo/semantics/openAccessBARBOSA,BRAINNER CAMPOSSANTOS,LEANDRO AUGUSTO RODRIGUESDAHER,GUSTAVO HENRIQUE RASSI MAHAMEDMARTINS,DANIEL LAHANPERALES,SIMONE REGESGALLANI,STEPHANIS KILARISCOSTA,LARISSA BASTOS ELOY DALAGO,EDUARDO ANDREAZZA DALBOIN,IIKA DE FÁTIMA SANTANTA FERREIRACASERTA,NELSON MARCIO GOMESATAÍDE,ELAINE CRISTINA DEeng2022-02-02T00:00:00Zoai:scielo:S0100-69912021000100239Revistahttp://www.scielo.br/rcbcONGhttps://old.scielo.br/oai/scielo-oai.php||revistacbc@cbc.org.br1809-45460100-6991opendoar:2022-02-02T00:00Revista do Colégio Brasileiro de Cirurgiões - Colégio Brasileiro de Cirurgiões (CBC)false
dc.title.none.fl_str_mv Clinical impact of the Model for End Liver Disease (MELD) score on the presence of microvascular invasion and on the postoperative outcome in patients undergoing liver transplantation
title Clinical impact of the Model for End Liver Disease (MELD) score on the presence of microvascular invasion and on the postoperative outcome in patients undergoing liver transplantation
spellingShingle Clinical impact of the Model for End Liver Disease (MELD) score on the presence of microvascular invasion and on the postoperative outcome in patients undergoing liver transplantation
BARBOSA,BRAINNER CAMPOS
Liver Neoplasms
Hepatic Cirrhosis
Liver transplant
title_short Clinical impact of the Model for End Liver Disease (MELD) score on the presence of microvascular invasion and on the postoperative outcome in patients undergoing liver transplantation
title_full Clinical impact of the Model for End Liver Disease (MELD) score on the presence of microvascular invasion and on the postoperative outcome in patients undergoing liver transplantation
title_fullStr Clinical impact of the Model for End Liver Disease (MELD) score on the presence of microvascular invasion and on the postoperative outcome in patients undergoing liver transplantation
title_full_unstemmed Clinical impact of the Model for End Liver Disease (MELD) score on the presence of microvascular invasion and on the postoperative outcome in patients undergoing liver transplantation
title_sort Clinical impact of the Model for End Liver Disease (MELD) score on the presence of microvascular invasion and on the postoperative outcome in patients undergoing liver transplantation
author BARBOSA,BRAINNER CAMPOS
author_facet BARBOSA,BRAINNER CAMPOS
SANTOS,LEANDRO AUGUSTO RODRIGUES
DAHER,GUSTAVO HENRIQUE RASSI MAHAMED
MARTINS,DANIEL LAHAN
PERALES,SIMONE REGES
GALLANI,STEPHANIS KILARIS
COSTA,LARISSA BASTOS ELOY DA
LAGO,EDUARDO ANDREAZZA DAL
BOIN,IIKA DE FÁTIMA SANTANTA FERREIRA
CASERTA,NELSON MARCIO GOMES
ATAÍDE,ELAINE CRISTINA DE
author_role author
author2 SANTOS,LEANDRO AUGUSTO RODRIGUES
DAHER,GUSTAVO HENRIQUE RASSI MAHAMED
MARTINS,DANIEL LAHAN
PERALES,SIMONE REGES
GALLANI,STEPHANIS KILARIS
COSTA,LARISSA BASTOS ELOY DA
LAGO,EDUARDO ANDREAZZA DAL
BOIN,IIKA DE FÁTIMA SANTANTA FERREIRA
CASERTA,NELSON MARCIO GOMES
ATAÍDE,ELAINE CRISTINA DE
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv BARBOSA,BRAINNER CAMPOS
SANTOS,LEANDRO AUGUSTO RODRIGUES
DAHER,GUSTAVO HENRIQUE RASSI MAHAMED
MARTINS,DANIEL LAHAN
PERALES,SIMONE REGES
GALLANI,STEPHANIS KILARIS
COSTA,LARISSA BASTOS ELOY DA
LAGO,EDUARDO ANDREAZZA DAL
BOIN,IIKA DE FÁTIMA SANTANTA FERREIRA
CASERTA,NELSON MARCIO GOMES
ATAÍDE,ELAINE CRISTINA DE
dc.subject.por.fl_str_mv Liver Neoplasms
Hepatic Cirrhosis
Liver transplant
topic Liver Neoplasms
Hepatic Cirrhosis
Liver transplant
description ABSTRACT Objective: to correlate clinical and epidemiological data with the pathological analysis of liver explants from patients undergoing liver transplantation for hetapocarcinoma in the UNICAMP HC and to verify whether the MELD and MELD-Na scores are reliable factors to predict a worse post-transplant prognosis. Methods: we studied liver transplants carried out between May 2010 and November 2017. After excluding 38 patients, we included 87, analyzing clinical and laboratory data for correlation with the outcome Microvascular Invasion (MVI). Subsequently, we computed the MELD and MELD-Na scores and performed a descriptive analysis of clinical and laboratory data and, finally, calculated ROC curves to assess the association between these laboratory parameters and mortality in these patients. Results: most patients were male (78.30%), with an average age of 58.53 years. Most liver diseases were caused by HCV (53.26%). We found no predictors for MVI among the laboratory parameters. The ROC curves for death identified the MELD score as the cutoff point with the highest combined sensitivity (90.91%) and specificity (37.50%), with a value of 10 points, whereas in the MELD-Na the cutoff point was 7 points, with a sensitivity of 90.91% and a specificity of 33.33%, both scores being significant. Conclusions: there were no reliable predictors of MVI between clinical, laboratory, and epidemiological variables. The MELD-Na score is more sensitive than the MELD one for predicting mortality in patients undergoing liver transplantation.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912021000100239
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912021000100239
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0100-6991e-20212997
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Colégio Brasileiro de Cirurgiões
publisher.none.fl_str_mv Colégio Brasileiro de Cirurgiões
dc.source.none.fl_str_mv Revista do Colégio Brasileiro de Cirurgiões v.48 2021
reponame:Revista do Colégio Brasileiro de Cirurgiões
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