A three-dimensional printed photopolymer resin implant for orbital rehabilitation for evisceration

Detalhes bibliográficos
Autor(a) principal: Kormann,Rodrigo Beraldi
Data de Publicação: 2019
Outros Autores: Mörschbächer,Ricardo, Moreira,Hamilton, Akaishi,Patricia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos brasileiros de oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492019000600471
Resumo: ABSTRACT Purpose: To evaluate the biocompatibility of three-dimensional (3D) printed orbital spheres for evisceration. Materials: A total of 10 consecutive patients (eight females and two males; mean age, 46.8 ± 14.2 years) underwent evisceration of blind painful eyes. 3D spherical implants produced by a rapid prototype machine were used to restore orbital volume. The implants were produced from a commercially available photocurable resin (Fullcure®). Systemic toxicity was evaluated by comparing serum biochemical measurements (creatine phosphokinase, aspartate aminotransferase, alanine aminotransferase, albumin, creatinine, urea, alkaline phosphatase, and C-reactive protein) before and at 12 months after surgery. Local toxicity was assessed by the evaluation of signs of socket inflammation at the first postoperative month. Changes in implant size were determined by computed tomography scans at 2 and 12 months after surgery. Results: The postoperative evaluations were uneventful. The biochemical evaluation showed no significant changes after surgery. None of the patients presented signs of orbital implant inflammation, infection, exposure, or extrusion. Computed tomography scan evaluations revealed no changes in implant size. Conclusion: To the best of our knowledge, this is the first phase-1 clinical study to certify the biocompatibility of the Fullcure resin for orbital implants in humans. The 3D printing technology permits fast and accurate production of implants for this purpose.
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spelling A three-dimensional printed photopolymer resin implant for orbital rehabilitation for eviscerationOrbit eviscerationOrbital diseases/rehabilitationOrbit/surgeryPrinting, three-dimensionalAcrylic resins/therapeutic useBiocompatible materialsOrbital implantsABSTRACT Purpose: To evaluate the biocompatibility of three-dimensional (3D) printed orbital spheres for evisceration. Materials: A total of 10 consecutive patients (eight females and two males; mean age, 46.8 ± 14.2 years) underwent evisceration of blind painful eyes. 3D spherical implants produced by a rapid prototype machine were used to restore orbital volume. The implants were produced from a commercially available photocurable resin (Fullcure®). Systemic toxicity was evaluated by comparing serum biochemical measurements (creatine phosphokinase, aspartate aminotransferase, alanine aminotransferase, albumin, creatinine, urea, alkaline phosphatase, and C-reactive protein) before and at 12 months after surgery. Local toxicity was assessed by the evaluation of signs of socket inflammation at the first postoperative month. Changes in implant size were determined by computed tomography scans at 2 and 12 months after surgery. Results: The postoperative evaluations were uneventful. The biochemical evaluation showed no significant changes after surgery. None of the patients presented signs of orbital implant inflammation, infection, exposure, or extrusion. Computed tomography scan evaluations revealed no changes in implant size. Conclusion: To the best of our knowledge, this is the first phase-1 clinical study to certify the biocompatibility of the Fullcure resin for orbital implants in humans. The 3D printing technology permits fast and accurate production of implants for this purpose.Conselho Brasileiro de Oftalmologia2019-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492019000600471Arquivos Brasileiros de Oftalmologia v.82 n.6 2019reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.5935/0004-2749.20190090info:eu-repo/semantics/openAccessKormann,Rodrigo BeraldiMörschbächer,RicardoMoreira,HamiltonAkaishi,Patriciaeng2019-10-21T00:00:00Zoai:scielo:S0004-27492019000600471Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2019-10-21T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false
dc.title.none.fl_str_mv A three-dimensional printed photopolymer resin implant for orbital rehabilitation for evisceration
title A three-dimensional printed photopolymer resin implant for orbital rehabilitation for evisceration
spellingShingle A three-dimensional printed photopolymer resin implant for orbital rehabilitation for evisceration
Kormann,Rodrigo Beraldi
Orbit evisceration
Orbital diseases/rehabilitation
Orbit/surgery
Printing, three-dimensional
Acrylic resins/therapeutic use
Biocompatible materials
Orbital implants
title_short A three-dimensional printed photopolymer resin implant for orbital rehabilitation for evisceration
title_full A three-dimensional printed photopolymer resin implant for orbital rehabilitation for evisceration
title_fullStr A three-dimensional printed photopolymer resin implant for orbital rehabilitation for evisceration
title_full_unstemmed A three-dimensional printed photopolymer resin implant for orbital rehabilitation for evisceration
title_sort A three-dimensional printed photopolymer resin implant for orbital rehabilitation for evisceration
author Kormann,Rodrigo Beraldi
author_facet Kormann,Rodrigo Beraldi
Mörschbächer,Ricardo
Moreira,Hamilton
Akaishi,Patricia
author_role author
author2 Mörschbächer,Ricardo
Moreira,Hamilton
Akaishi,Patricia
author2_role author
author
author
dc.contributor.author.fl_str_mv Kormann,Rodrigo Beraldi
Mörschbächer,Ricardo
Moreira,Hamilton
Akaishi,Patricia
dc.subject.por.fl_str_mv Orbit evisceration
Orbital diseases/rehabilitation
Orbit/surgery
Printing, three-dimensional
Acrylic resins/therapeutic use
Biocompatible materials
Orbital implants
topic Orbit evisceration
Orbital diseases/rehabilitation
Orbit/surgery
Printing, three-dimensional
Acrylic resins/therapeutic use
Biocompatible materials
Orbital implants
description ABSTRACT Purpose: To evaluate the biocompatibility of three-dimensional (3D) printed orbital spheres for evisceration. Materials: A total of 10 consecutive patients (eight females and two males; mean age, 46.8 ± 14.2 years) underwent evisceration of blind painful eyes. 3D spherical implants produced by a rapid prototype machine were used to restore orbital volume. The implants were produced from a commercially available photocurable resin (Fullcure®). Systemic toxicity was evaluated by comparing serum biochemical measurements (creatine phosphokinase, aspartate aminotransferase, alanine aminotransferase, albumin, creatinine, urea, alkaline phosphatase, and C-reactive protein) before and at 12 months after surgery. Local toxicity was assessed by the evaluation of signs of socket inflammation at the first postoperative month. Changes in implant size were determined by computed tomography scans at 2 and 12 months after surgery. Results: The postoperative evaluations were uneventful. The biochemical evaluation showed no significant changes after surgery. None of the patients presented signs of orbital implant inflammation, infection, exposure, or extrusion. Computed tomography scan evaluations revealed no changes in implant size. Conclusion: To the best of our knowledge, this is the first phase-1 clinical study to certify the biocompatibility of the Fullcure resin for orbital implants in humans. The 3D printing technology permits fast and accurate production of implants for this purpose.
publishDate 2019
dc.date.none.fl_str_mv 2019-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492019000600471
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492019000600471
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0004-2749.20190090
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Oftalmologia v.82 n.6 2019
reponame:Arquivos brasileiros de oftalmologia (Online)
instname:Conselho Brasileiro de Oftalmologia (CBO)
instacron:CBO
instname_str Conselho Brasileiro de Oftalmologia (CBO)
instacron_str CBO
institution CBO
reponame_str Arquivos brasileiros de oftalmologia (Online)
collection Arquivos brasileiros de oftalmologia (Online)
repository.name.fl_str_mv Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)
repository.mail.fl_str_mv aboonline@cbo.com.br||abo@cbo.com.br
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