A three-dimensional printed photopolymer resin implant for orbital rehabilitation for evisceration
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos brasileiros de oftalmologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492019000600471 |
Resumo: | ABSTRACT Purpose: To evaluate the biocompatibility of three-dimensional (3D) printed orbital spheres for evisceration. Materials: A total of 10 consecutive patients (eight females and two males; mean age, 46.8 ± 14.2 years) underwent evisceration of blind painful eyes. 3D spherical implants produced by a rapid prototype machine were used to restore orbital volume. The implants were produced from a commercially available photocurable resin (Fullcure®). Systemic toxicity was evaluated by comparing serum biochemical measurements (creatine phosphokinase, aspartate aminotransferase, alanine aminotransferase, albumin, creatinine, urea, alkaline phosphatase, and C-reactive protein) before and at 12 months after surgery. Local toxicity was assessed by the evaluation of signs of socket inflammation at the first postoperative month. Changes in implant size were determined by computed tomography scans at 2 and 12 months after surgery. Results: The postoperative evaluations were uneventful. The biochemical evaluation showed no significant changes after surgery. None of the patients presented signs of orbital implant inflammation, infection, exposure, or extrusion. Computed tomography scan evaluations revealed no changes in implant size. Conclusion: To the best of our knowledge, this is the first phase-1 clinical study to certify the biocompatibility of the Fullcure resin for orbital implants in humans. The 3D printing technology permits fast and accurate production of implants for this purpose. |
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Arquivos brasileiros de oftalmologia (Online) |
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A three-dimensional printed photopolymer resin implant for orbital rehabilitation for eviscerationOrbit eviscerationOrbital diseases/rehabilitationOrbit/surgeryPrinting, three-dimensionalAcrylic resins/therapeutic useBiocompatible materialsOrbital implantsABSTRACT Purpose: To evaluate the biocompatibility of three-dimensional (3D) printed orbital spheres for evisceration. Materials: A total of 10 consecutive patients (eight females and two males; mean age, 46.8 ± 14.2 years) underwent evisceration of blind painful eyes. 3D spherical implants produced by a rapid prototype machine were used to restore orbital volume. The implants were produced from a commercially available photocurable resin (Fullcure®). Systemic toxicity was evaluated by comparing serum biochemical measurements (creatine phosphokinase, aspartate aminotransferase, alanine aminotransferase, albumin, creatinine, urea, alkaline phosphatase, and C-reactive protein) before and at 12 months after surgery. Local toxicity was assessed by the evaluation of signs of socket inflammation at the first postoperative month. Changes in implant size were determined by computed tomography scans at 2 and 12 months after surgery. Results: The postoperative evaluations were uneventful. The biochemical evaluation showed no significant changes after surgery. None of the patients presented signs of orbital implant inflammation, infection, exposure, or extrusion. Computed tomography scan evaluations revealed no changes in implant size. Conclusion: To the best of our knowledge, this is the first phase-1 clinical study to certify the biocompatibility of the Fullcure resin for orbital implants in humans. The 3D printing technology permits fast and accurate production of implants for this purpose.Conselho Brasileiro de Oftalmologia2019-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492019000600471Arquivos Brasileiros de Oftalmologia v.82 n.6 2019reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.5935/0004-2749.20190090info:eu-repo/semantics/openAccessKormann,Rodrigo BeraldiMörschbächer,RicardoMoreira,HamiltonAkaishi,Patriciaeng2019-10-21T00:00:00Zoai:scielo:S0004-27492019000600471Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2019-10-21T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false |
dc.title.none.fl_str_mv |
A three-dimensional printed photopolymer resin implant for orbital rehabilitation for evisceration |
title |
A three-dimensional printed photopolymer resin implant for orbital rehabilitation for evisceration |
spellingShingle |
A three-dimensional printed photopolymer resin implant for orbital rehabilitation for evisceration Kormann,Rodrigo Beraldi Orbit evisceration Orbital diseases/rehabilitation Orbit/surgery Printing, three-dimensional Acrylic resins/therapeutic use Biocompatible materials Orbital implants |
title_short |
A three-dimensional printed photopolymer resin implant for orbital rehabilitation for evisceration |
title_full |
A three-dimensional printed photopolymer resin implant for orbital rehabilitation for evisceration |
title_fullStr |
A three-dimensional printed photopolymer resin implant for orbital rehabilitation for evisceration |
title_full_unstemmed |
A three-dimensional printed photopolymer resin implant for orbital rehabilitation for evisceration |
title_sort |
A three-dimensional printed photopolymer resin implant for orbital rehabilitation for evisceration |
author |
Kormann,Rodrigo Beraldi |
author_facet |
Kormann,Rodrigo Beraldi Mörschbächer,Ricardo Moreira,Hamilton Akaishi,Patricia |
author_role |
author |
author2 |
Mörschbächer,Ricardo Moreira,Hamilton Akaishi,Patricia |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Kormann,Rodrigo Beraldi Mörschbächer,Ricardo Moreira,Hamilton Akaishi,Patricia |
dc.subject.por.fl_str_mv |
Orbit evisceration Orbital diseases/rehabilitation Orbit/surgery Printing, three-dimensional Acrylic resins/therapeutic use Biocompatible materials Orbital implants |
topic |
Orbit evisceration Orbital diseases/rehabilitation Orbit/surgery Printing, three-dimensional Acrylic resins/therapeutic use Biocompatible materials Orbital implants |
description |
ABSTRACT Purpose: To evaluate the biocompatibility of three-dimensional (3D) printed orbital spheres for evisceration. Materials: A total of 10 consecutive patients (eight females and two males; mean age, 46.8 ± 14.2 years) underwent evisceration of blind painful eyes. 3D spherical implants produced by a rapid prototype machine were used to restore orbital volume. The implants were produced from a commercially available photocurable resin (Fullcure®). Systemic toxicity was evaluated by comparing serum biochemical measurements (creatine phosphokinase, aspartate aminotransferase, alanine aminotransferase, albumin, creatinine, urea, alkaline phosphatase, and C-reactive protein) before and at 12 months after surgery. Local toxicity was assessed by the evaluation of signs of socket inflammation at the first postoperative month. Changes in implant size were determined by computed tomography scans at 2 and 12 months after surgery. Results: The postoperative evaluations were uneventful. The biochemical evaluation showed no significant changes after surgery. None of the patients presented signs of orbital implant inflammation, infection, exposure, or extrusion. Computed tomography scan evaluations revealed no changes in implant size. Conclusion: To the best of our knowledge, this is the first phase-1 clinical study to certify the biocompatibility of the Fullcure resin for orbital implants in humans. The 3D printing technology permits fast and accurate production of implants for this purpose. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-11-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492019000600471 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492019000600471 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/0004-2749.20190090 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Oftalmologia v.82 n.6 2019 reponame:Arquivos brasileiros de oftalmologia (Online) instname:Conselho Brasileiro de Oftalmologia (CBO) instacron:CBO |
instname_str |
Conselho Brasileiro de Oftalmologia (CBO) |
instacron_str |
CBO |
institution |
CBO |
reponame_str |
Arquivos brasileiros de oftalmologia (Online) |
collection |
Arquivos brasileiros de oftalmologia (Online) |
repository.name.fl_str_mv |
Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO) |
repository.mail.fl_str_mv |
aboonline@cbo.com.br||abo@cbo.com.br |
_version_ |
1754209030404833280 |