Color vision loss in patients treated with chloroquine

Detalhes bibliográficos
Autor(a) principal: Ventura,Dora F.
Data de Publicação: 2003
Outros Autores: Silveira,Luiz Carlos L., Nishi,Mauro, Costa,Marcelo F., Gualtieri,Mirella, Santos,Ruth M. A. dos, Pinto,Carolina T., Moura,Ana Laura A. de, Rodrigues,Anderson R., Sakurada,Claudio, Sauma,Maria de Fátima L. C., Souza,John M. de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos brasileiros de oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492003000600002
Resumo: Patients that make use of chloroquine or hydroxychloroquine, drugs which are frequently administered for treatment of rheumatoid arthritis, lupus erithromatosus or malaria, may suffer alterations in color vision and in contrast sensitivity. The present work evaluates the visual function of these patients in a joint study of the University of São Paulo (USP), in São Paulo, and of the Federal University of Pará (UFPA), in Belém. Thirty two chloroquine user patients without alterations in the eye fundus exam were evaluated in São Paulo (n=10; aged 38 to 71 years; mean=55,8 years) and in Belém (n=22; aged 20 to 67; mean=40 years). The prescribed accumulated chloroquine dose was 45 to 430 g (mean=213 g; sd = 152 g) for the São Paulo group, and 36 to 540 g (mean=174 g; sd=183 g) for the Belém group. Tests were performed monocularly with corrected eye refractive state. Color discrimination was evaluated using the Cambridge Colour Test (CCT): the color discrimination threshold was measured first in the protan, deutan and tritan axes and, in succession, three MacAdam's ellipses were determined. The patient's color vision was also evaluated with color arrangement tests: the Farnsworth-Munsell 100 Hue (FM100), the Farnsworth-Munsell D15, and the Lanthony Desaturated (D15d) tests. We also measured the contrast sensitivity for black-and-white sine wave grating of twenty two patients. The results were compared with controls without ophthalmologic or neuro-ophthalmologic pathologies. Twenty four patients presented acquired dyschromatopsia. There were cases of selective loss (11 patients) and of diffuse loss (13 patients). Although losses were present in the FM100 there was no correlation between the FM100 error score and the ellipse area measured by the CCT. Moreover, three patients that scored normal in the FM100, failed to reach normal threshold in the CCT. The Lanthony test was less sensitive than the other two tests, since it failed to indicate loss in about half the patients, and the D15 was the least sensitive test, having failed to indicate loss in 9 out of 10 patients. Contrast sensitivity was within normal values for patients submitted to this test. The extent of losses in color discrimination was positively correlated with the accumulated dose. The CCT is recommended for follow up since it provides quantitative data that can be directly interpreted in CIE (Commission Internationalle d'Éclairage) color space.
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spelling Color vision loss in patients treated with chloroquineChloroquineRetinopathyColor visionContrast sensitivityNeurotoxicologyNeurobehavioral test batteryDyschromatopsiaPatients that make use of chloroquine or hydroxychloroquine, drugs which are frequently administered for treatment of rheumatoid arthritis, lupus erithromatosus or malaria, may suffer alterations in color vision and in contrast sensitivity. The present work evaluates the visual function of these patients in a joint study of the University of São Paulo (USP), in São Paulo, and of the Federal University of Pará (UFPA), in Belém. Thirty two chloroquine user patients without alterations in the eye fundus exam were evaluated in São Paulo (n=10; aged 38 to 71 years; mean=55,8 years) and in Belém (n=22; aged 20 to 67; mean=40 years). The prescribed accumulated chloroquine dose was 45 to 430 g (mean=213 g; sd = 152 g) for the São Paulo group, and 36 to 540 g (mean=174 g; sd=183 g) for the Belém group. Tests were performed monocularly with corrected eye refractive state. Color discrimination was evaluated using the Cambridge Colour Test (CCT): the color discrimination threshold was measured first in the protan, deutan and tritan axes and, in succession, three MacAdam's ellipses were determined. The patient's color vision was also evaluated with color arrangement tests: the Farnsworth-Munsell 100 Hue (FM100), the Farnsworth-Munsell D15, and the Lanthony Desaturated (D15d) tests. We also measured the contrast sensitivity for black-and-white sine wave grating of twenty two patients. The results were compared with controls without ophthalmologic or neuro-ophthalmologic pathologies. Twenty four patients presented acquired dyschromatopsia. There were cases of selective loss (11 patients) and of diffuse loss (13 patients). Although losses were present in the FM100 there was no correlation between the FM100 error score and the ellipse area measured by the CCT. Moreover, three patients that scored normal in the FM100, failed to reach normal threshold in the CCT. The Lanthony test was less sensitive than the other two tests, since it failed to indicate loss in about half the patients, and the D15 was the least sensitive test, having failed to indicate loss in 9 out of 10 patients. Contrast sensitivity was within normal values for patients submitted to this test. The extent of losses in color discrimination was positively correlated with the accumulated dose. The CCT is recommended for follow up since it provides quantitative data that can be directly interpreted in CIE (Commission Internationalle d'Éclairage) color space.Conselho Brasileiro de Oftalmologia2003-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492003000600002Arquivos Brasileiros de Oftalmologia v.66 n.5 suppl.0 2003reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.1590/S0004-27492003000600002info:eu-repo/semantics/openAccessVentura,Dora F.Silveira,Luiz Carlos L.Nishi,MauroCosta,Marcelo F.Gualtieri,MirellaSantos,Ruth M. A. dosPinto,Carolina T.Moura,Ana Laura A. deRodrigues,Anderson R.Sakurada,ClaudioSauma,Maria de Fátima L. C.Souza,John M. deeng2012-05-29T00:00:00Zoai:scielo:S0004-27492003000600002Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2012-05-29T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false
dc.title.none.fl_str_mv Color vision loss in patients treated with chloroquine
title Color vision loss in patients treated with chloroquine
spellingShingle Color vision loss in patients treated with chloroquine
Ventura,Dora F.
Chloroquine
Retinopathy
Color vision
Contrast sensitivity
Neurotoxicology
Neurobehavioral test battery
Dyschromatopsia
title_short Color vision loss in patients treated with chloroquine
title_full Color vision loss in patients treated with chloroquine
title_fullStr Color vision loss in patients treated with chloroquine
title_full_unstemmed Color vision loss in patients treated with chloroquine
title_sort Color vision loss in patients treated with chloroquine
author Ventura,Dora F.
author_facet Ventura,Dora F.
Silveira,Luiz Carlos L.
Nishi,Mauro
Costa,Marcelo F.
Gualtieri,Mirella
Santos,Ruth M. A. dos
Pinto,Carolina T.
Moura,Ana Laura A. de
Rodrigues,Anderson R.
Sakurada,Claudio
Sauma,Maria de Fátima L. C.
Souza,John M. de
author_role author
author2 Silveira,Luiz Carlos L.
Nishi,Mauro
Costa,Marcelo F.
Gualtieri,Mirella
Santos,Ruth M. A. dos
Pinto,Carolina T.
Moura,Ana Laura A. de
Rodrigues,Anderson R.
Sakurada,Claudio
Sauma,Maria de Fátima L. C.
Souza,John M. de
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ventura,Dora F.
Silveira,Luiz Carlos L.
Nishi,Mauro
Costa,Marcelo F.
Gualtieri,Mirella
Santos,Ruth M. A. dos
Pinto,Carolina T.
Moura,Ana Laura A. de
Rodrigues,Anderson R.
Sakurada,Claudio
Sauma,Maria de Fátima L. C.
Souza,John M. de
dc.subject.por.fl_str_mv Chloroquine
Retinopathy
Color vision
Contrast sensitivity
Neurotoxicology
Neurobehavioral test battery
Dyschromatopsia
topic Chloroquine
Retinopathy
Color vision
Contrast sensitivity
Neurotoxicology
Neurobehavioral test battery
Dyschromatopsia
description Patients that make use of chloroquine or hydroxychloroquine, drugs which are frequently administered for treatment of rheumatoid arthritis, lupus erithromatosus or malaria, may suffer alterations in color vision and in contrast sensitivity. The present work evaluates the visual function of these patients in a joint study of the University of São Paulo (USP), in São Paulo, and of the Federal University of Pará (UFPA), in Belém. Thirty two chloroquine user patients without alterations in the eye fundus exam were evaluated in São Paulo (n=10; aged 38 to 71 years; mean=55,8 years) and in Belém (n=22; aged 20 to 67; mean=40 years). The prescribed accumulated chloroquine dose was 45 to 430 g (mean=213 g; sd = 152 g) for the São Paulo group, and 36 to 540 g (mean=174 g; sd=183 g) for the Belém group. Tests were performed monocularly with corrected eye refractive state. Color discrimination was evaluated using the Cambridge Colour Test (CCT): the color discrimination threshold was measured first in the protan, deutan and tritan axes and, in succession, three MacAdam's ellipses were determined. The patient's color vision was also evaluated with color arrangement tests: the Farnsworth-Munsell 100 Hue (FM100), the Farnsworth-Munsell D15, and the Lanthony Desaturated (D15d) tests. We also measured the contrast sensitivity for black-and-white sine wave grating of twenty two patients. The results were compared with controls without ophthalmologic or neuro-ophthalmologic pathologies. Twenty four patients presented acquired dyschromatopsia. There were cases of selective loss (11 patients) and of diffuse loss (13 patients). Although losses were present in the FM100 there was no correlation between the FM100 error score and the ellipse area measured by the CCT. Moreover, three patients that scored normal in the FM100, failed to reach normal threshold in the CCT. The Lanthony test was less sensitive than the other two tests, since it failed to indicate loss in about half the patients, and the D15 was the least sensitive test, having failed to indicate loss in 9 out of 10 patients. Contrast sensitivity was within normal values for patients submitted to this test. The extent of losses in color discrimination was positively correlated with the accumulated dose. The CCT is recommended for follow up since it provides quantitative data that can be directly interpreted in CIE (Commission Internationalle d'Éclairage) color space.
publishDate 2003
dc.date.none.fl_str_mv 2003-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492003000600002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492003000600002
dc.language.iso.fl_str_mv eng
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Oftalmologia v.66 n.5 suppl.0 2003
reponame:Arquivos brasileiros de oftalmologia (Online)
instname:Conselho Brasileiro de Oftalmologia (CBO)
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reponame_str Arquivos brasileiros de oftalmologia (Online)
collection Arquivos brasileiros de oftalmologia (Online)
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