Microbiological efficacy of lomefloxacin and other drug's regarding microorganisms isolated from the human conjunctiva

• Autor(a) principal: Hofling-Lima,Ana Luísa
• Data de Publicação: 2001
• Outros Autores: Moeller,Cecília Tobias de Aguiar, Yu,Maria Cecília Zorat, Castelo Branco,Bruno, Farah,Michel Eid
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Arquivos brasileiros de oftalmologia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492001000200011
• topic: Quinolones/therapeutic use; Fluoroquinolones/pharmacology; Conjunctival diseases/therapy; Conjunctival diseases/microbiology

Purpose: To evaluate and compare the in vitro susceptibility of human conjunctival bacterial isolates to various antimicrobial agents, including lomefloxacin, other fluoroquinolones (ciprofloxacin, norfloxacin, and ofloxacin), aminoglycosides (gentamicin, tobramycin, and amicacin), and cephalosporin (cephalothin). Methods: Antibiotic susceptibility tests conducted over a period of 27 months with 613 bacterial isolates from the conjunctiva were retrospectively analyzed. Results: In relation to the total number of positive isolates, the fluoroquinolones showed greater in vitro effectiveness than the other analyzed antibiotics. All bacterial isolates showed significantly higher susceptibility to ciprofloxacin than to lomefloxacin. Conclusion: The fluoroquinolones are not only equally effective against all conjunctival bacterial isolates, but they also show superior antimicrobial activity in comparison to aminoglycosides and cephalothin. These results suggest that fluoroquinolones, such as lomefloxacin, can be beneficially prescribed for conjunctival infections and also as prophylaxis in ocular surgery.