Microbiological efficacy of lomefloxacin and other drug's regarding microorganisms isolated from the human conjunctiva

Detalhes bibliográficos
Autor(a) principal: Hofling-Lima, Ana Luisa [UNIFESP]
Data de Publicação: 2001
Outros Autores: Moeller, Cecilia Tobias de Aguiar [UNIFESP], Yu, Maria Cecília Zorat [UNIFESP], Branco, Bruno Castelo [UNIFESP], Farah, Michel Eid [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0004-27492001000200011
http://repositorio.unifesp.br/handle/11600/1141
Resumo: Purpose: To evaluate and compare the in vitro susceptibility of human conjunctival bacterial isolates to various antimicrobial agents, including lomefloxacin, other fluoroquinolones (ciprofloxacin, norfloxacin, and ofloxacin), aminoglycosides (gentamicin, tobramycin, and amicacin), and cephalosporin (cephalothin). Methods: Antibiotic susceptibility tests conducted over a period of 27 months with 613 bacterial isolates from the conjunctiva were retrospectively analyzed. Results: In relation to the total number of positive isolates, the fluoroquinolones showed greater in vitro effectiveness than the other analyzed antibiotics. All bacterial isolates showed significantly higher susceptibility to ciprofloxacin than to lomefloxacin. Conclusion: The fluoroquinolones are not only equally effective against all conjunctival bacterial isolates, but they also show superior antimicrobial activity in comparison to aminoglycosides and cephalothin. These results suggest that fluoroquinolones, such as lomefloxacin, can be beneficially prescribed for conjunctival infections and also as prophylaxis in ocular surgery.
id UFSP_8730449ec607d381b5cb266058844d66
oai_identifier_str oai:repositorio.unifesp.br/:11600/1141
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str 3465
spelling Microbiological efficacy of lomefloxacin and other drug's regarding microorganisms isolated from the human conjunctivaAtividade biocida da lomefloxacina em relação aos microorganismos isolados de conjuntiva humanaQuinolonesFluoroquinolonesConjunctival diseasesQuinolonasFluoroquinolonaDoenças da conjuntivaPurpose: To evaluate and compare the in vitro susceptibility of human conjunctival bacterial isolates to various antimicrobial agents, including lomefloxacin, other fluoroquinolones (ciprofloxacin, norfloxacin, and ofloxacin), aminoglycosides (gentamicin, tobramycin, and amicacin), and cephalosporin (cephalothin). Methods: Antibiotic susceptibility tests conducted over a period of 27 months with 613 bacterial isolates from the conjunctiva were retrospectively analyzed. Results: In relation to the total number of positive isolates, the fluoroquinolones showed greater in vitro effectiveness than the other analyzed antibiotics. All bacterial isolates showed significantly higher susceptibility to ciprofloxacin than to lomefloxacin. Conclusion: The fluoroquinolones are not only equally effective against all conjunctival bacterial isolates, but they also show superior antimicrobial activity in comparison to aminoglycosides and cephalothin. These results suggest that fluoroquinolones, such as lomefloxacin, can be beneficially prescribed for conjunctival infections and also as prophylaxis in ocular surgery.Objetivo: Avaliar e comparar a atividade biocida in vitro de bactérias isoladas da conjuntiva humana à lomefloxacina, a outras fluorquinolonas (ciprofloxacina, norfloxacina e ofloxacina), aos aminoglicosídeos (gentamicina, tobramicina e amicacina) e à cefalosporina (cefalotina). Métodos: Foram analisados retrospectivamente os resultados dos antibio-gramas realizados no período de 27 meses com 613 bactérias isoladas da conjuntiva. Resultados: A eficácia in vitro das quinolonas de acordo com o total dos isolamentos positivos foi superior em relação aos outros antibióticos avaliados. A suscetibilidade do total de bactérias à ciprofloxacina foi significantemente mais alta quando comparada à lomefloxacina. Conclusão: Os resultados praticamente equivalentes da suscetibilidade de bactérias isoladas da conjuntiva a fluorquinolonas, associado à maior eficácia deste grupo de antimicrobianos em relação aos aminoglicosídeos e à cefalotina, representam uma possibilidade de prescrição de quinolonas, como lomefloxacina, no tratamento de infecções conjuntivais, além do possível uso profilático em cirurgias oculares.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de OftalmologiaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUNIFESP, EPM, Depto. de OftalmologiaUNIFESP, EPMSciELOConselho Brasileiro de OftalmologiaUniversidade Federal de São Paulo (UNIFESP)Hofling-Lima, Ana Luisa [UNIFESP]Moeller, Cecilia Tobias de Aguiar [UNIFESP]Yu, Maria Cecília Zorat [UNIFESP]Branco, Bruno Castelo [UNIFESP]Farah, Michel Eid [UNIFESP]2015-06-14T13:29:22Z2015-06-14T13:29:22Z2001-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion147-151application/pdfhttp://dx.doi.org/10.1590/S0004-27492001000200011Arquivos Brasileiros de Oftalmologia. Conselho Brasileiro de Oftalmologia, v. 64, n. 2, p. 147-151, 2001.10.1590/S0004-27492001000200011S0004-27492001000200011.pdf0004-2749S0004-27492001000200011http://repositorio.unifesp.br/handle/11600/1141engArquivos Brasileiros de Oftalmologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T15:23:03Zoai:repositorio.unifesp.br/:11600/1141Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-05T15:23:03Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Microbiological efficacy of lomefloxacin and other drug's regarding microorganisms isolated from the human conjunctiva
Atividade biocida da lomefloxacina em relação aos microorganismos isolados de conjuntiva humana
title Microbiological efficacy of lomefloxacin and other drug's regarding microorganisms isolated from the human conjunctiva
spellingShingle Microbiological efficacy of lomefloxacin and other drug's regarding microorganisms isolated from the human conjunctiva
Hofling-Lima, Ana Luisa [UNIFESP]
Quinolones
Fluoroquinolones
Conjunctival diseases
Quinolonas
Fluoroquinolona
Doenças da conjuntiva
title_short Microbiological efficacy of lomefloxacin and other drug's regarding microorganisms isolated from the human conjunctiva
title_full Microbiological efficacy of lomefloxacin and other drug's regarding microorganisms isolated from the human conjunctiva
title_fullStr Microbiological efficacy of lomefloxacin and other drug's regarding microorganisms isolated from the human conjunctiva
title_full_unstemmed Microbiological efficacy of lomefloxacin and other drug's regarding microorganisms isolated from the human conjunctiva
title_sort Microbiological efficacy of lomefloxacin and other drug's regarding microorganisms isolated from the human conjunctiva
author Hofling-Lima, Ana Luisa [UNIFESP]
author_facet Hofling-Lima, Ana Luisa [UNIFESP]
Moeller, Cecilia Tobias de Aguiar [UNIFESP]
Yu, Maria Cecília Zorat [UNIFESP]
Branco, Bruno Castelo [UNIFESP]
Farah, Michel Eid [UNIFESP]
author_role author
author2 Moeller, Cecilia Tobias de Aguiar [UNIFESP]
Yu, Maria Cecília Zorat [UNIFESP]
Branco, Bruno Castelo [UNIFESP]
Farah, Michel Eid [UNIFESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Hofling-Lima, Ana Luisa [UNIFESP]
Moeller, Cecilia Tobias de Aguiar [UNIFESP]
Yu, Maria Cecília Zorat [UNIFESP]
Branco, Bruno Castelo [UNIFESP]
Farah, Michel Eid [UNIFESP]
dc.subject.por.fl_str_mv Quinolones
Fluoroquinolones
Conjunctival diseases
Quinolonas
Fluoroquinolona
Doenças da conjuntiva
topic Quinolones
Fluoroquinolones
Conjunctival diseases
Quinolonas
Fluoroquinolona
Doenças da conjuntiva
description Purpose: To evaluate and compare the in vitro susceptibility of human conjunctival bacterial isolates to various antimicrobial agents, including lomefloxacin, other fluoroquinolones (ciprofloxacin, norfloxacin, and ofloxacin), aminoglycosides (gentamicin, tobramycin, and amicacin), and cephalosporin (cephalothin). Methods: Antibiotic susceptibility tests conducted over a period of 27 months with 613 bacterial isolates from the conjunctiva were retrospectively analyzed. Results: In relation to the total number of positive isolates, the fluoroquinolones showed greater in vitro effectiveness than the other analyzed antibiotics. All bacterial isolates showed significantly higher susceptibility to ciprofloxacin than to lomefloxacin. Conclusion: The fluoroquinolones are not only equally effective against all conjunctival bacterial isolates, but they also show superior antimicrobial activity in comparison to aminoglycosides and cephalothin. These results suggest that fluoroquinolones, such as lomefloxacin, can be beneficially prescribed for conjunctival infections and also as prophylaxis in ocular surgery.
publishDate 2001
dc.date.none.fl_str_mv 2001-04-01
2015-06-14T13:29:22Z
2015-06-14T13:29:22Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0004-27492001000200011
Arquivos Brasileiros de Oftalmologia. Conselho Brasileiro de Oftalmologia, v. 64, n. 2, p. 147-151, 2001.
10.1590/S0004-27492001000200011
S0004-27492001000200011.pdf
0004-2749
S0004-27492001000200011
http://repositorio.unifesp.br/handle/11600/1141
url http://dx.doi.org/10.1590/S0004-27492001000200011
http://repositorio.unifesp.br/handle/11600/1141
identifier_str_mv Arquivos Brasileiros de Oftalmologia. Conselho Brasileiro de Oftalmologia, v. 64, n. 2, p. 147-151, 2001.
10.1590/S0004-27492001000200011
S0004-27492001000200011.pdf
0004-2749
S0004-27492001000200011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos Brasileiros de Oftalmologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 147-151
application/pdf
dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268390523535360

Registros relacionados