Ocular surface changes in the treatment of rosacea: comparison between low-dose oral isotretinoin and doxycycline
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos brasileiros de oftalmologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492020000200109 |
Resumo: | ABSTRACT Purpose: To compare the impact of ocular changes between systemic treatment with doxycycline and low-dose oral isotretinoin in patients with moderate-to-severe papulopustular rosacea. Methods: Patients were randomized to receive either isotretinoin 0.3-0.4 mg/kg (group A) or doxycycline 100 mg/day (group B) for 16 weeks. Ocular symptoms were searched and evaluated, including best-corrected visual acuity (BCVA), Schirmer test, breakup time, rose bengal staining score, and meibomian gland dysfunction grading. The patients were retested at the end of treatment. Results: The present study included 39 patients (30 females and 9 males). Best-corrected visual acuity was > 20/30 in >90% of patients in both groups and did not change after treatment. After treatment, improvement in ocular symptoms and meibomian gland dysfunction was more pronounced in group B (p<0.05); the other parameters did not reach statistical significance. Conclusion: Doxycycline improved meibomian gland dysfunction, ocular symptoms, and ocular surface in patients with rosacea. Even though some patients experienced worsening meibomian gland dysfunction and symptoms, no subject experienced any serious complications after administration of low-dose isotretinoin. |
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Arquivos brasileiros de oftalmologia (Online) |
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Ocular surface changes in the treatment of rosacea: comparison between low-dose oral isotretinoin and doxycyclineRosacea/drug therapyDoxycycline/therapeutic useDoxycycline/administration & dosageIsotretinoin/the rapeutic useIsotretinoin/administration & dosageOcular sur faceBlepharitisABSTRACT Purpose: To compare the impact of ocular changes between systemic treatment with doxycycline and low-dose oral isotretinoin in patients with moderate-to-severe papulopustular rosacea. Methods: Patients were randomized to receive either isotretinoin 0.3-0.4 mg/kg (group A) or doxycycline 100 mg/day (group B) for 16 weeks. Ocular symptoms were searched and evaluated, including best-corrected visual acuity (BCVA), Schirmer test, breakup time, rose bengal staining score, and meibomian gland dysfunction grading. The patients were retested at the end of treatment. Results: The present study included 39 patients (30 females and 9 males). Best-corrected visual acuity was > 20/30 in >90% of patients in both groups and did not change after treatment. After treatment, improvement in ocular symptoms and meibomian gland dysfunction was more pronounced in group B (p<0.05); the other parameters did not reach statistical significance. Conclusion: Doxycycline improved meibomian gland dysfunction, ocular symptoms, and ocular surface in patients with rosacea. Even though some patients experienced worsening meibomian gland dysfunction and symptoms, no subject experienced any serious complications after administration of low-dose isotretinoin.Conselho Brasileiro de Oftalmologia2020-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492020000200109Arquivos Brasileiros de Oftalmologia v.83 n.2 2020reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.5935/0004-2749.20200016info:eu-repo/semantics/openAccessAndrade,Fabio Mendonça XavierPicosse,Fabiola RosaCunha,Laura Pires daValente,Camila MaiaBezerra,Fernanda MachadoMiot,HelioBagatin,EdileiaFreitas,Denise deeng2020-03-10T00:00:00Zoai:scielo:S0004-27492020000200109Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2020-03-10T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false |
dc.title.none.fl_str_mv |
Ocular surface changes in the treatment of rosacea: comparison between low-dose oral isotretinoin and doxycycline |
title |
Ocular surface changes in the treatment of rosacea: comparison between low-dose oral isotretinoin and doxycycline |
spellingShingle |
Ocular surface changes in the treatment of rosacea: comparison between low-dose oral isotretinoin and doxycycline Andrade,Fabio Mendonça Xavier Rosacea/drug therapy Doxycycline/therapeutic use Doxycycline/administration & dosage Isotretinoin/the rapeutic use Isotretinoin/administration & dosage Ocular sur face Blepharitis |
title_short |
Ocular surface changes in the treatment of rosacea: comparison between low-dose oral isotretinoin and doxycycline |
title_full |
Ocular surface changes in the treatment of rosacea: comparison between low-dose oral isotretinoin and doxycycline |
title_fullStr |
Ocular surface changes in the treatment of rosacea: comparison between low-dose oral isotretinoin and doxycycline |
title_full_unstemmed |
Ocular surface changes in the treatment of rosacea: comparison between low-dose oral isotretinoin and doxycycline |
title_sort |
Ocular surface changes in the treatment of rosacea: comparison between low-dose oral isotretinoin and doxycycline |
author |
Andrade,Fabio Mendonça Xavier |
author_facet |
Andrade,Fabio Mendonça Xavier Picosse,Fabiola Rosa Cunha,Laura Pires da Valente,Camila Maia Bezerra,Fernanda Machado Miot,Helio Bagatin,Edileia Freitas,Denise de |
author_role |
author |
author2 |
Picosse,Fabiola Rosa Cunha,Laura Pires da Valente,Camila Maia Bezerra,Fernanda Machado Miot,Helio Bagatin,Edileia Freitas,Denise de |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Andrade,Fabio Mendonça Xavier Picosse,Fabiola Rosa Cunha,Laura Pires da Valente,Camila Maia Bezerra,Fernanda Machado Miot,Helio Bagatin,Edileia Freitas,Denise de |
dc.subject.por.fl_str_mv |
Rosacea/drug therapy Doxycycline/therapeutic use Doxycycline/administration & dosage Isotretinoin/the rapeutic use Isotretinoin/administration & dosage Ocular sur face Blepharitis |
topic |
Rosacea/drug therapy Doxycycline/therapeutic use Doxycycline/administration & dosage Isotretinoin/the rapeutic use Isotretinoin/administration & dosage Ocular sur face Blepharitis |
description |
ABSTRACT Purpose: To compare the impact of ocular changes between systemic treatment with doxycycline and low-dose oral isotretinoin in patients with moderate-to-severe papulopustular rosacea. Methods: Patients were randomized to receive either isotretinoin 0.3-0.4 mg/kg (group A) or doxycycline 100 mg/day (group B) for 16 weeks. Ocular symptoms were searched and evaluated, including best-corrected visual acuity (BCVA), Schirmer test, breakup time, rose bengal staining score, and meibomian gland dysfunction grading. The patients were retested at the end of treatment. Results: The present study included 39 patients (30 females and 9 males). Best-corrected visual acuity was > 20/30 in >90% of patients in both groups and did not change after treatment. After treatment, improvement in ocular symptoms and meibomian gland dysfunction was more pronounced in group B (p<0.05); the other parameters did not reach statistical significance. Conclusion: Doxycycline improved meibomian gland dysfunction, ocular symptoms, and ocular surface in patients with rosacea. Even though some patients experienced worsening meibomian gland dysfunction and symptoms, no subject experienced any serious complications after administration of low-dose isotretinoin. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492020000200109 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492020000200109 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/0004-2749.20200016 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Oftalmologia v.83 n.2 2020 reponame:Arquivos brasileiros de oftalmologia (Online) instname:Conselho Brasileiro de Oftalmologia (CBO) instacron:CBO |
instname_str |
Conselho Brasileiro de Oftalmologia (CBO) |
instacron_str |
CBO |
institution |
CBO |
reponame_str |
Arquivos brasileiros de oftalmologia (Online) |
collection |
Arquivos brasileiros de oftalmologia (Online) |
repository.name.fl_str_mv |
Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO) |
repository.mail.fl_str_mv |
aboonline@cbo.com.br||abo@cbo.com.br |
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1754209030476136448 |