The role of molecular genetic factors in age-related macular degeneration
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos brasileiros de oftalmologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492009000400027 |
Resumo: | Age-related macular degeneration (AMD) is the most frequent cause of irreversible blindness in the elderly in developed countries. Although the etiology of AMD remains largely unknown, numerous studies have suggested that both genes and environmental risk factors significantly influence the risk of developing AMD. Recently, single nucleotide polymorphisms, DNA sequence variations found within the complement factor H (CFH) gene, have been found to be strongly associated with the development of AMD. Several other genes have had at least one positive association finding and deserve further exploration. The purpose of this review is to provide an extensive report of the current data of AMD genetics and the contribution of this knowledge helps to the better understanding of its pathophysiology. |
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Arquivos brasileiros de oftalmologia (Online) |
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The role of molecular genetic factors in age-related macular degenerationMacular degeneration/etiologyAge effectComplement factor H/geneticsBase sequencePolymorphism, single nucleotideInflammationAge-related macular degeneration (AMD) is the most frequent cause of irreversible blindness in the elderly in developed countries. Although the etiology of AMD remains largely unknown, numerous studies have suggested that both genes and environmental risk factors significantly influence the risk of developing AMD. Recently, single nucleotide polymorphisms, DNA sequence variations found within the complement factor H (CFH) gene, have been found to be strongly associated with the development of AMD. Several other genes have had at least one positive association finding and deserve further exploration. The purpose of this review is to provide an extensive report of the current data of AMD genetics and the contribution of this knowledge helps to the better understanding of its pathophysiology.Conselho Brasileiro de Oftalmologia2009-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492009000400027Arquivos Brasileiros de Oftalmologia v.72 n.4 2009reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.1590/S0004-27492009000400027info:eu-repo/semantics/openAccessAlmeida,Luciana Negrão Frota deCarolino,Rachel MeliloSperandio,Diogo CazelliNehemy,Márcio BittarDe Marco,LAeng2009-10-06T00:00:00Zoai:scielo:S0004-27492009000400027Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2009-10-06T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false |
dc.title.none.fl_str_mv |
The role of molecular genetic factors in age-related macular degeneration |
title |
The role of molecular genetic factors in age-related macular degeneration |
spellingShingle |
The role of molecular genetic factors in age-related macular degeneration Almeida,Luciana Negrão Frota de Macular degeneration/etiology Age effect Complement factor H/genetics Base sequence Polymorphism, single nucleotide Inflammation |
title_short |
The role of molecular genetic factors in age-related macular degeneration |
title_full |
The role of molecular genetic factors in age-related macular degeneration |
title_fullStr |
The role of molecular genetic factors in age-related macular degeneration |
title_full_unstemmed |
The role of molecular genetic factors in age-related macular degeneration |
title_sort |
The role of molecular genetic factors in age-related macular degeneration |
author |
Almeida,Luciana Negrão Frota de |
author_facet |
Almeida,Luciana Negrão Frota de Carolino,Rachel Melilo Sperandio,Diogo Cazelli Nehemy,Márcio Bittar De Marco,LA |
author_role |
author |
author2 |
Carolino,Rachel Melilo Sperandio,Diogo Cazelli Nehemy,Márcio Bittar De Marco,LA |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Almeida,Luciana Negrão Frota de Carolino,Rachel Melilo Sperandio,Diogo Cazelli Nehemy,Márcio Bittar De Marco,LA |
dc.subject.por.fl_str_mv |
Macular degeneration/etiology Age effect Complement factor H/genetics Base sequence Polymorphism, single nucleotide Inflammation |
topic |
Macular degeneration/etiology Age effect Complement factor H/genetics Base sequence Polymorphism, single nucleotide Inflammation |
description |
Age-related macular degeneration (AMD) is the most frequent cause of irreversible blindness in the elderly in developed countries. Although the etiology of AMD remains largely unknown, numerous studies have suggested that both genes and environmental risk factors significantly influence the risk of developing AMD. Recently, single nucleotide polymorphisms, DNA sequence variations found within the complement factor H (CFH) gene, have been found to be strongly associated with the development of AMD. Several other genes have had at least one positive association finding and deserve further exploration. The purpose of this review is to provide an extensive report of the current data of AMD genetics and the contribution of this knowledge helps to the better understanding of its pathophysiology. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492009000400027 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492009000400027 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-27492009000400027 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Oftalmologia v.72 n.4 2009 reponame:Arquivos brasileiros de oftalmologia (Online) instname:Conselho Brasileiro de Oftalmologia (CBO) instacron:CBO |
instname_str |
Conselho Brasileiro de Oftalmologia (CBO) |
instacron_str |
CBO |
institution |
CBO |
reponame_str |
Arquivos brasileiros de oftalmologia (Online) |
collection |
Arquivos brasileiros de oftalmologia (Online) |
repository.name.fl_str_mv |
Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO) |
repository.mail.fl_str_mv |
aboonline@cbo.com.br||abo@cbo.com.br |
_version_ |
1754209025985085440 |