New insights into Vogt-Koyanagi-Harada disease

Detalhes bibliográficos
Autor(a) principal: Damico,Francisco Max
Data de Publicação: 2009
Outros Autores: Bezerra,Felipe Theodoro, Silva,Gaspar Carvalho da, Gasparin,Fábio, Yamamoto,Joyce Hisae
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Arquivos brasileiros de oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492009000300028
Resumo: Vogt-Koyanagi-Harada disease (VKH), a well-established multiorgan disorder affecting pigmented structures, is an autoimmune disorder of melanocyte proteins in genetically susceptible individuals. Several clinical and experimental data point to the importance of the effector role of CD4+ T cells and Th1 cytokines, the relevance of searching a target protein in the melanocyte, and the relevance of the HLA-DRB1*0405 in the pathogenesis of the disease. Vogt-Koyanagi-Harada disease has a benign course when early diagnosed and adequatey treated. Full-blown recurrences are rare after the acute stage of Vogt-Koyanagi-Harada disease is over. On the other hand, clinical findings, such as progressive tissue depigmentation (including sunset glow fundus) and uveitis recurrence, indicate that ocular inflammation may persist after the acute phase. Additionally, indocyanine green angiography findings suggest the presence of choroidal inflammation in eyes without clinically detectable inflammation. The aim of this paper is to review the latest research results on Vogt-Koyanagi-Harada disease pathogenesis and chronic/convalescent stages, which may help to better understand this potentially blinding disease and to improve its treatment.
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spelling New insights into Vogt-Koyanagi-Harada diseaseUveomeningoencephalitic syndromeUveitis/etiologyChronic diseaseAutoimune diseases/immunologyHLA-DR antigensMelanocytes/immunologyReviewVogt-Koyanagi-Harada disease (VKH), a well-established multiorgan disorder affecting pigmented structures, is an autoimmune disorder of melanocyte proteins in genetically susceptible individuals. Several clinical and experimental data point to the importance of the effector role of CD4+ T cells and Th1 cytokines, the relevance of searching a target protein in the melanocyte, and the relevance of the HLA-DRB1*0405 in the pathogenesis of the disease. Vogt-Koyanagi-Harada disease has a benign course when early diagnosed and adequatey treated. Full-blown recurrences are rare after the acute stage of Vogt-Koyanagi-Harada disease is over. On the other hand, clinical findings, such as progressive tissue depigmentation (including sunset glow fundus) and uveitis recurrence, indicate that ocular inflammation may persist after the acute phase. Additionally, indocyanine green angiography findings suggest the presence of choroidal inflammation in eyes without clinically detectable inflammation. The aim of this paper is to review the latest research results on Vogt-Koyanagi-Harada disease pathogenesis and chronic/convalescent stages, which may help to better understand this potentially blinding disease and to improve its treatment.Conselho Brasileiro de Oftalmologia2009-06-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492009000300028Arquivos Brasileiros de Oftalmologia v.72 n.3 2009reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.1590/S0004-27492009000300028info:eu-repo/semantics/openAccessDamico,Francisco MaxBezerra,Felipe TheodoroSilva,Gaspar Carvalho daGasparin,FábioYamamoto,Joyce Hisaeeng2009-08-04T00:00:00Zoai:scielo:S0004-27492009000300028Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2009-08-04T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false
dc.title.none.fl_str_mv New insights into Vogt-Koyanagi-Harada disease
title New insights into Vogt-Koyanagi-Harada disease
spellingShingle New insights into Vogt-Koyanagi-Harada disease
Damico,Francisco Max
Uveomeningoencephalitic syndrome
Uveitis/etiology
Chronic disease
Autoimune diseases/immunology
HLA-DR antigens
Melanocytes/immunology
Review
title_short New insights into Vogt-Koyanagi-Harada disease
title_full New insights into Vogt-Koyanagi-Harada disease
title_fullStr New insights into Vogt-Koyanagi-Harada disease
title_full_unstemmed New insights into Vogt-Koyanagi-Harada disease
title_sort New insights into Vogt-Koyanagi-Harada disease
author Damico,Francisco Max
author_facet Damico,Francisco Max
Bezerra,Felipe Theodoro
Silva,Gaspar Carvalho da
Gasparin,Fábio
Yamamoto,Joyce Hisae
author_role author
author2 Bezerra,Felipe Theodoro
Silva,Gaspar Carvalho da
Gasparin,Fábio
Yamamoto,Joyce Hisae
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Damico,Francisco Max
Bezerra,Felipe Theodoro
Silva,Gaspar Carvalho da
Gasparin,Fábio
Yamamoto,Joyce Hisae
dc.subject.por.fl_str_mv Uveomeningoencephalitic syndrome
Uveitis/etiology
Chronic disease
Autoimune diseases/immunology
HLA-DR antigens
Melanocytes/immunology
Review
topic Uveomeningoencephalitic syndrome
Uveitis/etiology
Chronic disease
Autoimune diseases/immunology
HLA-DR antigens
Melanocytes/immunology
Review
description Vogt-Koyanagi-Harada disease (VKH), a well-established multiorgan disorder affecting pigmented structures, is an autoimmune disorder of melanocyte proteins in genetically susceptible individuals. Several clinical and experimental data point to the importance of the effector role of CD4+ T cells and Th1 cytokines, the relevance of searching a target protein in the melanocyte, and the relevance of the HLA-DRB1*0405 in the pathogenesis of the disease. Vogt-Koyanagi-Harada disease has a benign course when early diagnosed and adequatey treated. Full-blown recurrences are rare after the acute stage of Vogt-Koyanagi-Harada disease is over. On the other hand, clinical findings, such as progressive tissue depigmentation (including sunset glow fundus) and uveitis recurrence, indicate that ocular inflammation may persist after the acute phase. Additionally, indocyanine green angiography findings suggest the presence of choroidal inflammation in eyes without clinically detectable inflammation. The aim of this paper is to review the latest research results on Vogt-Koyanagi-Harada disease pathogenesis and chronic/convalescent stages, which may help to better understand this potentially blinding disease and to improve its treatment.
publishDate 2009
dc.date.none.fl_str_mv 2009-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492009000300028
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492009000300028
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27492009000300028
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Oftalmologia v.72 n.3 2009
reponame:Arquivos brasileiros de oftalmologia (Online)
instname:Conselho Brasileiro de Oftalmologia (CBO)
instacron:CBO
instname_str Conselho Brasileiro de Oftalmologia (CBO)
instacron_str CBO
institution CBO
reponame_str Arquivos brasileiros de oftalmologia (Online)
collection Arquivos brasileiros de oftalmologia (Online)
repository.name.fl_str_mv Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)
repository.mail.fl_str_mv aboonline@cbo.com.br||abo@cbo.com.br
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