New insights into Vogt-Koyanagi-Harada disease
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Arquivos brasileiros de oftalmologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492009000300028 |
Resumo: | Vogt-Koyanagi-Harada disease (VKH), a well-established multiorgan disorder affecting pigmented structures, is an autoimmune disorder of melanocyte proteins in genetically susceptible individuals. Several clinical and experimental data point to the importance of the effector role of CD4+ T cells and Th1 cytokines, the relevance of searching a target protein in the melanocyte, and the relevance of the HLA-DRB1*0405 in the pathogenesis of the disease. Vogt-Koyanagi-Harada disease has a benign course when early diagnosed and adequatey treated. Full-blown recurrences are rare after the acute stage of Vogt-Koyanagi-Harada disease is over. On the other hand, clinical findings, such as progressive tissue depigmentation (including sunset glow fundus) and uveitis recurrence, indicate that ocular inflammation may persist after the acute phase. Additionally, indocyanine green angiography findings suggest the presence of choroidal inflammation in eyes without clinically detectable inflammation. The aim of this paper is to review the latest research results on Vogt-Koyanagi-Harada disease pathogenesis and chronic/convalescent stages, which may help to better understand this potentially blinding disease and to improve its treatment. |
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New insights into Vogt-Koyanagi-Harada diseaseUveomeningoencephalitic syndromeUveitis/etiologyChronic diseaseAutoimune diseases/immunologyHLA-DR antigensMelanocytes/immunologyReviewVogt-Koyanagi-Harada disease (VKH), a well-established multiorgan disorder affecting pigmented structures, is an autoimmune disorder of melanocyte proteins in genetically susceptible individuals. Several clinical and experimental data point to the importance of the effector role of CD4+ T cells and Th1 cytokines, the relevance of searching a target protein in the melanocyte, and the relevance of the HLA-DRB1*0405 in the pathogenesis of the disease. Vogt-Koyanagi-Harada disease has a benign course when early diagnosed and adequatey treated. Full-blown recurrences are rare after the acute stage of Vogt-Koyanagi-Harada disease is over. On the other hand, clinical findings, such as progressive tissue depigmentation (including sunset glow fundus) and uveitis recurrence, indicate that ocular inflammation may persist after the acute phase. Additionally, indocyanine green angiography findings suggest the presence of choroidal inflammation in eyes without clinically detectable inflammation. The aim of this paper is to review the latest research results on Vogt-Koyanagi-Harada disease pathogenesis and chronic/convalescent stages, which may help to better understand this potentially blinding disease and to improve its treatment.Conselho Brasileiro de Oftalmologia2009-06-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492009000300028Arquivos Brasileiros de Oftalmologia v.72 n.3 2009reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.1590/S0004-27492009000300028info:eu-repo/semantics/openAccessDamico,Francisco MaxBezerra,Felipe TheodoroSilva,Gaspar Carvalho daGasparin,FábioYamamoto,Joyce Hisaeeng2009-08-04T00:00:00Zoai:scielo:S0004-27492009000300028Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2009-08-04T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false |
dc.title.none.fl_str_mv |
New insights into Vogt-Koyanagi-Harada disease |
title |
New insights into Vogt-Koyanagi-Harada disease |
spellingShingle |
New insights into Vogt-Koyanagi-Harada disease Damico,Francisco Max Uveomeningoencephalitic syndrome Uveitis/etiology Chronic disease Autoimune diseases/immunology HLA-DR antigens Melanocytes/immunology Review |
title_short |
New insights into Vogt-Koyanagi-Harada disease |
title_full |
New insights into Vogt-Koyanagi-Harada disease |
title_fullStr |
New insights into Vogt-Koyanagi-Harada disease |
title_full_unstemmed |
New insights into Vogt-Koyanagi-Harada disease |
title_sort |
New insights into Vogt-Koyanagi-Harada disease |
author |
Damico,Francisco Max |
author_facet |
Damico,Francisco Max Bezerra,Felipe Theodoro Silva,Gaspar Carvalho da Gasparin,Fábio Yamamoto,Joyce Hisae |
author_role |
author |
author2 |
Bezerra,Felipe Theodoro Silva,Gaspar Carvalho da Gasparin,Fábio Yamamoto,Joyce Hisae |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Damico,Francisco Max Bezerra,Felipe Theodoro Silva,Gaspar Carvalho da Gasparin,Fábio Yamamoto,Joyce Hisae |
dc.subject.por.fl_str_mv |
Uveomeningoencephalitic syndrome Uveitis/etiology Chronic disease Autoimune diseases/immunology HLA-DR antigens Melanocytes/immunology Review |
topic |
Uveomeningoencephalitic syndrome Uveitis/etiology Chronic disease Autoimune diseases/immunology HLA-DR antigens Melanocytes/immunology Review |
description |
Vogt-Koyanagi-Harada disease (VKH), a well-established multiorgan disorder affecting pigmented structures, is an autoimmune disorder of melanocyte proteins in genetically susceptible individuals. Several clinical and experimental data point to the importance of the effector role of CD4+ T cells and Th1 cytokines, the relevance of searching a target protein in the melanocyte, and the relevance of the HLA-DRB1*0405 in the pathogenesis of the disease. Vogt-Koyanagi-Harada disease has a benign course when early diagnosed and adequatey treated. Full-blown recurrences are rare after the acute stage of Vogt-Koyanagi-Harada disease is over. On the other hand, clinical findings, such as progressive tissue depigmentation (including sunset glow fundus) and uveitis recurrence, indicate that ocular inflammation may persist after the acute phase. Additionally, indocyanine green angiography findings suggest the presence of choroidal inflammation in eyes without clinically detectable inflammation. The aim of this paper is to review the latest research results on Vogt-Koyanagi-Harada disease pathogenesis and chronic/convalescent stages, which may help to better understand this potentially blinding disease and to improve its treatment. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492009000300028 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492009000300028 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-27492009000300028 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Oftalmologia v.72 n.3 2009 reponame:Arquivos brasileiros de oftalmologia (Online) instname:Conselho Brasileiro de Oftalmologia (CBO) instacron:CBO |
instname_str |
Conselho Brasileiro de Oftalmologia (CBO) |
instacron_str |
CBO |
institution |
CBO |
reponame_str |
Arquivos brasileiros de oftalmologia (Online) |
collection |
Arquivos brasileiros de oftalmologia (Online) |
repository.name.fl_str_mv |
Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO) |
repository.mail.fl_str_mv |
aboonline@cbo.com.br||abo@cbo.com.br |
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1754209025936850944 |