HLA-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term results

Detalhes bibliográficos
Autor(a) principal: Scocco,Caio
Data de Publicação: 2008
Outros Autores: Kwitko,Sérgio, Rymer,Samuel, Marinho,Diane, Bocaccio,Francisco, Lindenmeyer,Rodrigo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos brasileiros de oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492008000600003
Resumo: PURPOSE: To evaluate the long-term outcome of HLA-matched lr-CLAL for bilateral ocular surface disorders. METHODS: A retrospective, non-comparative interventional case series study of 39 eyes of 32 patients with bilateral surface disorders and clinical diagnosis of limbal stem cell deficiency who underwent HLA-matched lr-CLAL. Visual acuity (VA), ambulatory vision (> 20/200) and ocular surface stability were evaluated as main outcomes. Donor limbus was obtained from a sibling or a parent of the patient, after an appropriate Class I and II HLA match. RESULTS: One year after surgery, VA improved in 46.2%, ambulatory vision was achieved in 48.7% and a stable corneal surface was achieved in 84.6% of the eyes. At the final follow-up (mean, 48.7 ± 30.6 months), 66.6% of the eyes that had gained VA one year after surgery maintained an improved VA (p=0.28), 94.7% of eyes that had achieved ambulatory vision one year after surgery maintained 20/200 or better (p<0.001) and 93.9% still had a stable corneal surface (p=0.043) at the final follow-up. CONCLUSIONS: HLA-matched lr-CLAL can be an adequate method of treatment for bilateral ocular surface disorders, with a reasonable percentage of success of long-term results.
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spelling HLA-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term resultsTransplantation, homologous/methodsCornea limbus/surgeryLiving donorsHLA antigensPURPOSE: To evaluate the long-term outcome of HLA-matched lr-CLAL for bilateral ocular surface disorders. METHODS: A retrospective, non-comparative interventional case series study of 39 eyes of 32 patients with bilateral surface disorders and clinical diagnosis of limbal stem cell deficiency who underwent HLA-matched lr-CLAL. Visual acuity (VA), ambulatory vision (> 20/200) and ocular surface stability were evaluated as main outcomes. Donor limbus was obtained from a sibling or a parent of the patient, after an appropriate Class I and II HLA match. RESULTS: One year after surgery, VA improved in 46.2%, ambulatory vision was achieved in 48.7% and a stable corneal surface was achieved in 84.6% of the eyes. At the final follow-up (mean, 48.7 ± 30.6 months), 66.6% of the eyes that had gained VA one year after surgery maintained an improved VA (p=0.28), 94.7% of eyes that had achieved ambulatory vision one year after surgery maintained 20/200 or better (p<0.001) and 93.9% still had a stable corneal surface (p=0.043) at the final follow-up. CONCLUSIONS: HLA-matched lr-CLAL can be an adequate method of treatment for bilateral ocular surface disorders, with a reasonable percentage of success of long-term results.Conselho Brasileiro de Oftalmologia2008-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492008000600003Arquivos Brasileiros de Oftalmologia v.71 n.6 2008reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.1590/S0004-27492008000600003info:eu-repo/semantics/openAccessScocco,CaioKwitko,SérgioRymer,SamuelMarinho,DianeBocaccio,FranciscoLindenmeyer,Rodrigoeng2009-01-19T00:00:00Zoai:scielo:S0004-27492008000600003Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2009-01-19T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false
dc.title.none.fl_str_mv HLA-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term results
title HLA-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term results
spellingShingle HLA-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term results
Scocco,Caio
Transplantation, homologous/methods
Cornea limbus/surgery
Living donors
HLA antigens
title_short HLA-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term results
title_full HLA-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term results
title_fullStr HLA-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term results
title_full_unstemmed HLA-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term results
title_sort HLA-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term results
author Scocco,Caio
author_facet Scocco,Caio
Kwitko,Sérgio
Rymer,Samuel
Marinho,Diane
Bocaccio,Francisco
Lindenmeyer,Rodrigo
author_role author
author2 Kwitko,Sérgio
Rymer,Samuel
Marinho,Diane
Bocaccio,Francisco
Lindenmeyer,Rodrigo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Scocco,Caio
Kwitko,Sérgio
Rymer,Samuel
Marinho,Diane
Bocaccio,Francisco
Lindenmeyer,Rodrigo
dc.subject.por.fl_str_mv Transplantation, homologous/methods
Cornea limbus/surgery
Living donors
HLA antigens
topic Transplantation, homologous/methods
Cornea limbus/surgery
Living donors
HLA antigens
description PURPOSE: To evaluate the long-term outcome of HLA-matched lr-CLAL for bilateral ocular surface disorders. METHODS: A retrospective, non-comparative interventional case series study of 39 eyes of 32 patients with bilateral surface disorders and clinical diagnosis of limbal stem cell deficiency who underwent HLA-matched lr-CLAL. Visual acuity (VA), ambulatory vision (> 20/200) and ocular surface stability were evaluated as main outcomes. Donor limbus was obtained from a sibling or a parent of the patient, after an appropriate Class I and II HLA match. RESULTS: One year after surgery, VA improved in 46.2%, ambulatory vision was achieved in 48.7% and a stable corneal surface was achieved in 84.6% of the eyes. At the final follow-up (mean, 48.7 ± 30.6 months), 66.6% of the eyes that had gained VA one year after surgery maintained an improved VA (p=0.28), 94.7% of eyes that had achieved ambulatory vision one year after surgery maintained 20/200 or better (p<0.001) and 93.9% still had a stable corneal surface (p=0.043) at the final follow-up. CONCLUSIONS: HLA-matched lr-CLAL can be an adequate method of treatment for bilateral ocular surface disorders, with a reasonable percentage of success of long-term results.
publishDate 2008
dc.date.none.fl_str_mv 2008-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492008000600003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492008000600003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27492008000600003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Oftalmologia v.71 n.6 2008
reponame:Arquivos brasileiros de oftalmologia (Online)
instname:Conselho Brasileiro de Oftalmologia (CBO)
instacron:CBO
instname_str Conselho Brasileiro de Oftalmologia (CBO)
instacron_str CBO
institution CBO
reponame_str Arquivos brasileiros de oftalmologia (Online)
collection Arquivos brasileiros de oftalmologia (Online)
repository.name.fl_str_mv Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)
repository.mail.fl_str_mv aboonline@cbo.com.br||abo@cbo.com.br
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