HLA-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term results
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos brasileiros de oftalmologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492008000600003 |
Resumo: | PURPOSE: To evaluate the long-term outcome of HLA-matched lr-CLAL for bilateral ocular surface disorders. METHODS: A retrospective, non-comparative interventional case series study of 39 eyes of 32 patients with bilateral surface disorders and clinical diagnosis of limbal stem cell deficiency who underwent HLA-matched lr-CLAL. Visual acuity (VA), ambulatory vision (> 20/200) and ocular surface stability were evaluated as main outcomes. Donor limbus was obtained from a sibling or a parent of the patient, after an appropriate Class I and II HLA match. RESULTS: One year after surgery, VA improved in 46.2%, ambulatory vision was achieved in 48.7% and a stable corneal surface was achieved in 84.6% of the eyes. At the final follow-up (mean, 48.7 ± 30.6 months), 66.6% of the eyes that had gained VA one year after surgery maintained an improved VA (p=0.28), 94.7% of eyes that had achieved ambulatory vision one year after surgery maintained 20/200 or better (p<0.001) and 93.9% still had a stable corneal surface (p=0.043) at the final follow-up. CONCLUSIONS: HLA-matched lr-CLAL can be an adequate method of treatment for bilateral ocular surface disorders, with a reasonable percentage of success of long-term results. |
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Arquivos brasileiros de oftalmologia (Online) |
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HLA-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term resultsTransplantation, homologous/methodsCornea limbus/surgeryLiving donorsHLA antigensPURPOSE: To evaluate the long-term outcome of HLA-matched lr-CLAL for bilateral ocular surface disorders. METHODS: A retrospective, non-comparative interventional case series study of 39 eyes of 32 patients with bilateral surface disorders and clinical diagnosis of limbal stem cell deficiency who underwent HLA-matched lr-CLAL. Visual acuity (VA), ambulatory vision (> 20/200) and ocular surface stability were evaluated as main outcomes. Donor limbus was obtained from a sibling or a parent of the patient, after an appropriate Class I and II HLA match. RESULTS: One year after surgery, VA improved in 46.2%, ambulatory vision was achieved in 48.7% and a stable corneal surface was achieved in 84.6% of the eyes. At the final follow-up (mean, 48.7 ± 30.6 months), 66.6% of the eyes that had gained VA one year after surgery maintained an improved VA (p=0.28), 94.7% of eyes that had achieved ambulatory vision one year after surgery maintained 20/200 or better (p<0.001) and 93.9% still had a stable corneal surface (p=0.043) at the final follow-up. CONCLUSIONS: HLA-matched lr-CLAL can be an adequate method of treatment for bilateral ocular surface disorders, with a reasonable percentage of success of long-term results.Conselho Brasileiro de Oftalmologia2008-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492008000600003Arquivos Brasileiros de Oftalmologia v.71 n.6 2008reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.1590/S0004-27492008000600003info:eu-repo/semantics/openAccessScocco,CaioKwitko,SérgioRymer,SamuelMarinho,DianeBocaccio,FranciscoLindenmeyer,Rodrigoeng2009-01-19T00:00:00Zoai:scielo:S0004-27492008000600003Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2009-01-19T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false |
dc.title.none.fl_str_mv |
HLA-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term results |
title |
HLA-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term results |
spellingShingle |
HLA-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term results Scocco,Caio Transplantation, homologous/methods Cornea limbus/surgery Living donors HLA antigens |
title_short |
HLA-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term results |
title_full |
HLA-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term results |
title_fullStr |
HLA-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term results |
title_full_unstemmed |
HLA-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term results |
title_sort |
HLA-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term results |
author |
Scocco,Caio |
author_facet |
Scocco,Caio Kwitko,Sérgio Rymer,Samuel Marinho,Diane Bocaccio,Francisco Lindenmeyer,Rodrigo |
author_role |
author |
author2 |
Kwitko,Sérgio Rymer,Samuel Marinho,Diane Bocaccio,Francisco Lindenmeyer,Rodrigo |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Scocco,Caio Kwitko,Sérgio Rymer,Samuel Marinho,Diane Bocaccio,Francisco Lindenmeyer,Rodrigo |
dc.subject.por.fl_str_mv |
Transplantation, homologous/methods Cornea limbus/surgery Living donors HLA antigens |
topic |
Transplantation, homologous/methods Cornea limbus/surgery Living donors HLA antigens |
description |
PURPOSE: To evaluate the long-term outcome of HLA-matched lr-CLAL for bilateral ocular surface disorders. METHODS: A retrospective, non-comparative interventional case series study of 39 eyes of 32 patients with bilateral surface disorders and clinical diagnosis of limbal stem cell deficiency who underwent HLA-matched lr-CLAL. Visual acuity (VA), ambulatory vision (> 20/200) and ocular surface stability were evaluated as main outcomes. Donor limbus was obtained from a sibling or a parent of the patient, after an appropriate Class I and II HLA match. RESULTS: One year after surgery, VA improved in 46.2%, ambulatory vision was achieved in 48.7% and a stable corneal surface was achieved in 84.6% of the eyes. At the final follow-up (mean, 48.7 ± 30.6 months), 66.6% of the eyes that had gained VA one year after surgery maintained an improved VA (p=0.28), 94.7% of eyes that had achieved ambulatory vision one year after surgery maintained 20/200 or better (p<0.001) and 93.9% still had a stable corneal surface (p=0.043) at the final follow-up. CONCLUSIONS: HLA-matched lr-CLAL can be an adequate method of treatment for bilateral ocular surface disorders, with a reasonable percentage of success of long-term results. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492008000600003 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492008000600003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-27492008000600003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Oftalmologia v.71 n.6 2008 reponame:Arquivos brasileiros de oftalmologia (Online) instname:Conselho Brasileiro de Oftalmologia (CBO) instacron:CBO |
instname_str |
Conselho Brasileiro de Oftalmologia (CBO) |
instacron_str |
CBO |
institution |
CBO |
reponame_str |
Arquivos brasileiros de oftalmologia (Online) |
collection |
Arquivos brasileiros de oftalmologia (Online) |
repository.name.fl_str_mv |
Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO) |
repository.mail.fl_str_mv |
aboonline@cbo.com.br||abo@cbo.com.br |
_version_ |
1754209025462894592 |