Mechanisms and biomarker candidates in pterygium development

Detalhes bibliográficos
Autor(a) principal: Wanzeler,Ana Cláudia Viana
Data de Publicação: 2019
Outros Autores: Barbosa,Italo Antunes França, Duarte,Bruna, Borges,Daniel, Barbosa,Eduardo Buzolin, Kamiji,Danielle, Huarachi,Delma Regina Gomes, Melo,Mônica Barbosa de, Alves,Mônica
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos brasileiros de oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492019000600528
Resumo: ABSTRACT Pterygium pathogenesis has been mainly asso ciated with UV light exposure; however, this association remains quite controversial. The complete mechanism of pterygium also remains to be clarified. Factors such as inflammation, viral infection, oxidative stress, DNA methylation, inflammatory mediators, extracellular matrix modulators, apoptotic and oncogenic proteins, loss of heterozygosity, microsatellite instability, lymphangiogenesis, epithelial-mesenchymal cell transition, and alterations in cholesterol metabolism have been identified as causes. Several studies aimed to clarify the molecular mechanisms underlying the growth and proliferation of pterygium. Understanding its molecular basis provides new potential therapeutic targets for its prevention and treatment. A comprehensive search of the databases, namely, MedLine, EMBASE, and LILACS, was conducted with the following key words: pterygium, epidemiology, pathogenesis, biomarkers, and review. This review describes the epidemiology, clinical presentation, and current investigation of biological mediators involved in pterygium development.
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spelling Mechanisms and biomarker candidates in pterygium developmentPterygium/epidemiologypathogenesisBiomarkersReviewABSTRACT Pterygium pathogenesis has been mainly asso ciated with UV light exposure; however, this association remains quite controversial. The complete mechanism of pterygium also remains to be clarified. Factors such as inflammation, viral infection, oxidative stress, DNA methylation, inflammatory mediators, extracellular matrix modulators, apoptotic and oncogenic proteins, loss of heterozygosity, microsatellite instability, lymphangiogenesis, epithelial-mesenchymal cell transition, and alterations in cholesterol metabolism have been identified as causes. Several studies aimed to clarify the molecular mechanisms underlying the growth and proliferation of pterygium. Understanding its molecular basis provides new potential therapeutic targets for its prevention and treatment. A comprehensive search of the databases, namely, MedLine, EMBASE, and LILACS, was conducted with the following key words: pterygium, epidemiology, pathogenesis, biomarkers, and review. This review describes the epidemiology, clinical presentation, and current investigation of biological mediators involved in pterygium development.Conselho Brasileiro de Oftalmologia2019-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492019000600528Arquivos Brasileiros de Oftalmologia v.82 n.6 2019reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.5935/0004-2749.20190103info:eu-repo/semantics/openAccessWanzeler,Ana Cláudia VianaBarbosa,Italo Antunes FrançaDuarte,BrunaBorges,DanielBarbosa,Eduardo BuzolinKamiji,DanielleHuarachi,Delma Regina GomesMelo,Mônica Barbosa deAlves,Mônicaeng2019-10-21T00:00:00Zoai:scielo:S0004-27492019000600528Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2019-10-21T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false
dc.title.none.fl_str_mv Mechanisms and biomarker candidates in pterygium development
title Mechanisms and biomarker candidates in pterygium development
spellingShingle Mechanisms and biomarker candidates in pterygium development
Wanzeler,Ana Cláudia Viana
Pterygium/epidemiology
pathogenesis
Biomarkers
Review
title_short Mechanisms and biomarker candidates in pterygium development
title_full Mechanisms and biomarker candidates in pterygium development
title_fullStr Mechanisms and biomarker candidates in pterygium development
title_full_unstemmed Mechanisms and biomarker candidates in pterygium development
title_sort Mechanisms and biomarker candidates in pterygium development
author Wanzeler,Ana Cláudia Viana
author_facet Wanzeler,Ana Cláudia Viana
Barbosa,Italo Antunes França
Duarte,Bruna
Borges,Daniel
Barbosa,Eduardo Buzolin
Kamiji,Danielle
Huarachi,Delma Regina Gomes
Melo,Mônica Barbosa de
Alves,Mônica
author_role author
author2 Barbosa,Italo Antunes França
Duarte,Bruna
Borges,Daniel
Barbosa,Eduardo Buzolin
Kamiji,Danielle
Huarachi,Delma Regina Gomes
Melo,Mônica Barbosa de
Alves,Mônica
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Wanzeler,Ana Cláudia Viana
Barbosa,Italo Antunes França
Duarte,Bruna
Borges,Daniel
Barbosa,Eduardo Buzolin
Kamiji,Danielle
Huarachi,Delma Regina Gomes
Melo,Mônica Barbosa de
Alves,Mônica
dc.subject.por.fl_str_mv Pterygium/epidemiology
pathogenesis
Biomarkers
Review
topic Pterygium/epidemiology
pathogenesis
Biomarkers
Review
description ABSTRACT Pterygium pathogenesis has been mainly asso ciated with UV light exposure; however, this association remains quite controversial. The complete mechanism of pterygium also remains to be clarified. Factors such as inflammation, viral infection, oxidative stress, DNA methylation, inflammatory mediators, extracellular matrix modulators, apoptotic and oncogenic proteins, loss of heterozygosity, microsatellite instability, lymphangiogenesis, epithelial-mesenchymal cell transition, and alterations in cholesterol metabolism have been identified as causes. Several studies aimed to clarify the molecular mechanisms underlying the growth and proliferation of pterygium. Understanding its molecular basis provides new potential therapeutic targets for its prevention and treatment. A comprehensive search of the databases, namely, MedLine, EMBASE, and LILACS, was conducted with the following key words: pterygium, epidemiology, pathogenesis, biomarkers, and review. This review describes the epidemiology, clinical presentation, and current investigation of biological mediators involved in pterygium development.
publishDate 2019
dc.date.none.fl_str_mv 2019-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492019000600528
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492019000600528
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0004-2749.20190103
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Oftalmologia v.82 n.6 2019
reponame:Arquivos brasileiros de oftalmologia (Online)
instname:Conselho Brasileiro de Oftalmologia (CBO)
instacron:CBO
instname_str Conselho Brasileiro de Oftalmologia (CBO)
instacron_str CBO
institution CBO
reponame_str Arquivos brasileiros de oftalmologia (Online)
collection Arquivos brasileiros de oftalmologia (Online)
repository.name.fl_str_mv Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)
repository.mail.fl_str_mv aboonline@cbo.com.br||abo@cbo.com.br
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