Tear film and ocular surface alterations in chronic users of antiglaucoma medications

Detalhes bibliográficos
Autor(a) principal: Baffa,Lina do Prado
Data de Publicação: 2008
Outros Autores: Ricardo,Jose Reinaldo da Silva, Dias,Ana Carolina, Módulo,Carolina Maria, Braz,Alexandre Martins, Paula,Jayter Silva de, Rodrigues,Maria de Lourdes Veronese, Rocha,Eduardo Melani
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos brasileiros de oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492008000100004
Resumo: PURPOSE: Tear film can be altered by chronic medications that may disrupt the equilibrium responsible for the functioning of the lacrimal gland and ocular surface. The purpose of this study was to determine if antiglaucomatous chronic treatment induced alterations in the tear film and ocular surface. METHODS: After informed consent, 21 patients using antiglaucomatous eye drops for more than 8 months and 20 age- and sex-matched volunteers without eye and systemic medications (control group) were enrolled. The data of ocular discomfort, fluorescein and lisamine green staining, tear film break-up time and Schirmer test were collected and compared by Student's t test. The impression cytology data were graded and compared by chi-square test. RESULTS: Patients chronically using antiglaucomatous medications presented with significant higher fluorescein staining (p=0.003), lisamine green staining (p=0.02) and lower TFBUT (p=0.001). The other comparedparameters, including impression cytology were similar between the treated and control group (p>0.05). CONCLUSIONS: The present study shows that the tear film and the ocular surface are altered in patients under antiglaucomatous medications. In common, all medications were preserved with benzalkonium chloride. Efforts to minimize the adverse effects of chronic use of antiglaucomatous drugs must be addressed.
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spelling Tear film and ocular surface alterations in chronic users of antiglaucoma medicationsBenzalkonium compounds/administration & dosageBenzalkonium compounds/drug effectsTimolol/administration & dosageTimolol/drug effectsTears/drug effectsOptic/drug effectsGlaucoma/drug therapyDry eye syndromesIndicators and reagentsPURPOSE: Tear film can be altered by chronic medications that may disrupt the equilibrium responsible for the functioning of the lacrimal gland and ocular surface. The purpose of this study was to determine if antiglaucomatous chronic treatment induced alterations in the tear film and ocular surface. METHODS: After informed consent, 21 patients using antiglaucomatous eye drops for more than 8 months and 20 age- and sex-matched volunteers without eye and systemic medications (control group) were enrolled. The data of ocular discomfort, fluorescein and lisamine green staining, tear film break-up time and Schirmer test were collected and compared by Student's t test. The impression cytology data were graded and compared by chi-square test. RESULTS: Patients chronically using antiglaucomatous medications presented with significant higher fluorescein staining (p=0.003), lisamine green staining (p=0.02) and lower TFBUT (p=0.001). The other comparedparameters, including impression cytology were similar between the treated and control group (p>0.05). CONCLUSIONS: The present study shows that the tear film and the ocular surface are altered in patients under antiglaucomatous medications. In common, all medications were preserved with benzalkonium chloride. Efforts to minimize the adverse effects of chronic use of antiglaucomatous drugs must be addressed.Conselho Brasileiro de Oftalmologia2008-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492008000100004Arquivos Brasileiros de Oftalmologia v.71 n.1 2008reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.1590/S0004-27492008000100004info:eu-repo/semantics/openAccessBaffa,Lina do PradoRicardo,Jose Reinaldo da SilvaDias,Ana CarolinaMódulo,Carolina MariaBraz,Alexandre MartinsPaula,Jayter Silva deRodrigues,Maria de Lourdes VeroneseRocha,Eduardo Melanieng2008-04-10T00:00:00Zoai:scielo:S0004-27492008000100004Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2008-04-10T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false
dc.title.none.fl_str_mv Tear film and ocular surface alterations in chronic users of antiglaucoma medications
title Tear film and ocular surface alterations in chronic users of antiglaucoma medications
spellingShingle Tear film and ocular surface alterations in chronic users of antiglaucoma medications
Baffa,Lina do Prado
Benzalkonium compounds/administration & dosage
Benzalkonium compounds/drug effects
Timolol/administration & dosage
Timolol/drug effects
Tears/drug effects
Optic/drug effects
Glaucoma/drug therapy
Dry eye syndromes
Indicators and reagents
title_short Tear film and ocular surface alterations in chronic users of antiglaucoma medications
title_full Tear film and ocular surface alterations in chronic users of antiglaucoma medications
title_fullStr Tear film and ocular surface alterations in chronic users of antiglaucoma medications
title_full_unstemmed Tear film and ocular surface alterations in chronic users of antiglaucoma medications
title_sort Tear film and ocular surface alterations in chronic users of antiglaucoma medications
author Baffa,Lina do Prado
author_facet Baffa,Lina do Prado
Ricardo,Jose Reinaldo da Silva
Dias,Ana Carolina
Módulo,Carolina Maria
Braz,Alexandre Martins
Paula,Jayter Silva de
Rodrigues,Maria de Lourdes Veronese
Rocha,Eduardo Melani
author_role author
author2 Ricardo,Jose Reinaldo da Silva
Dias,Ana Carolina
Módulo,Carolina Maria
Braz,Alexandre Martins
Paula,Jayter Silva de
Rodrigues,Maria de Lourdes Veronese
Rocha,Eduardo Melani
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Baffa,Lina do Prado
Ricardo,Jose Reinaldo da Silva
Dias,Ana Carolina
Módulo,Carolina Maria
Braz,Alexandre Martins
Paula,Jayter Silva de
Rodrigues,Maria de Lourdes Veronese
Rocha,Eduardo Melani
dc.subject.por.fl_str_mv Benzalkonium compounds/administration & dosage
Benzalkonium compounds/drug effects
Timolol/administration & dosage
Timolol/drug effects
Tears/drug effects
Optic/drug effects
Glaucoma/drug therapy
Dry eye syndromes
Indicators and reagents
topic Benzalkonium compounds/administration & dosage
Benzalkonium compounds/drug effects
Timolol/administration & dosage
Timolol/drug effects
Tears/drug effects
Optic/drug effects
Glaucoma/drug therapy
Dry eye syndromes
Indicators and reagents
description PURPOSE: Tear film can be altered by chronic medications that may disrupt the equilibrium responsible for the functioning of the lacrimal gland and ocular surface. The purpose of this study was to determine if antiglaucomatous chronic treatment induced alterations in the tear film and ocular surface. METHODS: After informed consent, 21 patients using antiglaucomatous eye drops for more than 8 months and 20 age- and sex-matched volunteers without eye and systemic medications (control group) were enrolled. The data of ocular discomfort, fluorescein and lisamine green staining, tear film break-up time and Schirmer test were collected and compared by Student's t test. The impression cytology data were graded and compared by chi-square test. RESULTS: Patients chronically using antiglaucomatous medications presented with significant higher fluorescein staining (p=0.003), lisamine green staining (p=0.02) and lower TFBUT (p=0.001). The other comparedparameters, including impression cytology were similar between the treated and control group (p>0.05). CONCLUSIONS: The present study shows that the tear film and the ocular surface are altered in patients under antiglaucomatous medications. In common, all medications were preserved with benzalkonium chloride. Efforts to minimize the adverse effects of chronic use of antiglaucomatous drugs must be addressed.
publishDate 2008
dc.date.none.fl_str_mv 2008-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492008000100004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492008000100004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27492008000100004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Oftalmologia v.71 n.1 2008
reponame:Arquivos brasileiros de oftalmologia (Online)
instname:Conselho Brasileiro de Oftalmologia (CBO)
instacron:CBO
instname_str Conselho Brasileiro de Oftalmologia (CBO)
instacron_str CBO
institution CBO
reponame_str Arquivos brasileiros de oftalmologia (Online)
collection Arquivos brasileiros de oftalmologia (Online)
repository.name.fl_str_mv Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)
repository.mail.fl_str_mv aboonline@cbo.com.br||abo@cbo.com.br
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