Rationale for anti-inflammatory therapy in dry eye syndrome

Detalhes bibliográficos
Autor(a) principal: De Paiva,CS
Data de Publicação: 2008
Outros Autores: Pflugfelder,SC
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos brasileiros de oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492008000700017
Resumo: Dry eye is a multifactorial condition that results in a dysfunctional lacrimal functional unit. Evidence suggests that inflammation is involved in the pathogenesis of the disease. Changes in tear composition including increased cytokines, chemokines, metalloproteinases and the number of T cells in the conjunctiva are found in dry eye patients and in animal models. This inflammation is responsible in part for the irritation symptoms, ocular surface epithelial disease, and altered corneal epithelial barrier function in dry eye. There are several anti-inflammatory therapies for dry eye that target one or more of the inflammatory mediators/pathways that have been identified and are discussed in detail.
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spelling Rationale for anti-inflammatory therapy in dry eye syndromeDry eye syndromesInflammationConcentration osmolarCyclosporine/therapeutic useDoxycycline/therapeutic useCytokines/therapeutic useMetalloproteasesAnti-Inflammatory agents/therapeutic useDry eye is a multifactorial condition that results in a dysfunctional lacrimal functional unit. Evidence suggests that inflammation is involved in the pathogenesis of the disease. Changes in tear composition including increased cytokines, chemokines, metalloproteinases and the number of T cells in the conjunctiva are found in dry eye patients and in animal models. This inflammation is responsible in part for the irritation symptoms, ocular surface epithelial disease, and altered corneal epithelial barrier function in dry eye. There are several anti-inflammatory therapies for dry eye that target one or more of the inflammatory mediators/pathways that have been identified and are discussed in detail.Conselho Brasileiro de Oftalmologia2008-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492008000700017Arquivos Brasileiros de Oftalmologia v.71 n.6 suppl.0 2008reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.1590/S0004-27492008000700017info:eu-repo/semantics/openAccessDe Paiva,CSPflugfelder,SCeng2009-03-02T00:00:00Zoai:scielo:S0004-27492008000700017Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2009-03-02T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false
dc.title.none.fl_str_mv Rationale for anti-inflammatory therapy in dry eye syndrome
title Rationale for anti-inflammatory therapy in dry eye syndrome
spellingShingle Rationale for anti-inflammatory therapy in dry eye syndrome
De Paiva,CS
Dry eye syndromes
Inflammation
Concentration osmolar
Cyclosporine/therapeutic use
Doxycycline/therapeutic use
Cytokines/therapeutic use
Metalloproteases
Anti-Inflammatory agents/therapeutic use
title_short Rationale for anti-inflammatory therapy in dry eye syndrome
title_full Rationale for anti-inflammatory therapy in dry eye syndrome
title_fullStr Rationale for anti-inflammatory therapy in dry eye syndrome
title_full_unstemmed Rationale for anti-inflammatory therapy in dry eye syndrome
title_sort Rationale for anti-inflammatory therapy in dry eye syndrome
author De Paiva,CS
author_facet De Paiva,CS
Pflugfelder,SC
author_role author
author2 Pflugfelder,SC
author2_role author
dc.contributor.author.fl_str_mv De Paiva,CS
Pflugfelder,SC
dc.subject.por.fl_str_mv Dry eye syndromes
Inflammation
Concentration osmolar
Cyclosporine/therapeutic use
Doxycycline/therapeutic use
Cytokines/therapeutic use
Metalloproteases
Anti-Inflammatory agents/therapeutic use
topic Dry eye syndromes
Inflammation
Concentration osmolar
Cyclosporine/therapeutic use
Doxycycline/therapeutic use
Cytokines/therapeutic use
Metalloproteases
Anti-Inflammatory agents/therapeutic use
description Dry eye is a multifactorial condition that results in a dysfunctional lacrimal functional unit. Evidence suggests that inflammation is involved in the pathogenesis of the disease. Changes in tear composition including increased cytokines, chemokines, metalloproteinases and the number of T cells in the conjunctiva are found in dry eye patients and in animal models. This inflammation is responsible in part for the irritation symptoms, ocular surface epithelial disease, and altered corneal epithelial barrier function in dry eye. There are several anti-inflammatory therapies for dry eye that target one or more of the inflammatory mediators/pathways that have been identified and are discussed in detail.
publishDate 2008
dc.date.none.fl_str_mv 2008-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492008000700017
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492008000700017
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27492008000700017
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Oftalmologia v.71 n.6 suppl.0 2008
reponame:Arquivos brasileiros de oftalmologia (Online)
instname:Conselho Brasileiro de Oftalmologia (CBO)
instacron:CBO
instname_str Conselho Brasileiro de Oftalmologia (CBO)
instacron_str CBO
institution CBO
reponame_str Arquivos brasileiros de oftalmologia (Online)
collection Arquivos brasileiros de oftalmologia (Online)
repository.name.fl_str_mv Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)
repository.mail.fl_str_mv aboonline@cbo.com.br||abo@cbo.com.br
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