Rationale for anti-inflammatory therapy in dry eye syndrome
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos brasileiros de oftalmologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492008000700017 |
Resumo: | Dry eye is a multifactorial condition that results in a dysfunctional lacrimal functional unit. Evidence suggests that inflammation is involved in the pathogenesis of the disease. Changes in tear composition including increased cytokines, chemokines, metalloproteinases and the number of T cells in the conjunctiva are found in dry eye patients and in animal models. This inflammation is responsible in part for the irritation symptoms, ocular surface epithelial disease, and altered corneal epithelial barrier function in dry eye. There are several anti-inflammatory therapies for dry eye that target one or more of the inflammatory mediators/pathways that have been identified and are discussed in detail. |
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Arquivos brasileiros de oftalmologia (Online) |
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Rationale for anti-inflammatory therapy in dry eye syndromeDry eye syndromesInflammationConcentration osmolarCyclosporine/therapeutic useDoxycycline/therapeutic useCytokines/therapeutic useMetalloproteasesAnti-Inflammatory agents/therapeutic useDry eye is a multifactorial condition that results in a dysfunctional lacrimal functional unit. Evidence suggests that inflammation is involved in the pathogenesis of the disease. Changes in tear composition including increased cytokines, chemokines, metalloproteinases and the number of T cells in the conjunctiva are found in dry eye patients and in animal models. This inflammation is responsible in part for the irritation symptoms, ocular surface epithelial disease, and altered corneal epithelial barrier function in dry eye. There are several anti-inflammatory therapies for dry eye that target one or more of the inflammatory mediators/pathways that have been identified and are discussed in detail.Conselho Brasileiro de Oftalmologia2008-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492008000700017Arquivos Brasileiros de Oftalmologia v.71 n.6 suppl.0 2008reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.1590/S0004-27492008000700017info:eu-repo/semantics/openAccessDe Paiva,CSPflugfelder,SCeng2009-03-02T00:00:00Zoai:scielo:S0004-27492008000700017Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2009-03-02T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false |
dc.title.none.fl_str_mv |
Rationale for anti-inflammatory therapy in dry eye syndrome |
title |
Rationale for anti-inflammatory therapy in dry eye syndrome |
spellingShingle |
Rationale for anti-inflammatory therapy in dry eye syndrome De Paiva,CS Dry eye syndromes Inflammation Concentration osmolar Cyclosporine/therapeutic use Doxycycline/therapeutic use Cytokines/therapeutic use Metalloproteases Anti-Inflammatory agents/therapeutic use |
title_short |
Rationale for anti-inflammatory therapy in dry eye syndrome |
title_full |
Rationale for anti-inflammatory therapy in dry eye syndrome |
title_fullStr |
Rationale for anti-inflammatory therapy in dry eye syndrome |
title_full_unstemmed |
Rationale for anti-inflammatory therapy in dry eye syndrome |
title_sort |
Rationale for anti-inflammatory therapy in dry eye syndrome |
author |
De Paiva,CS |
author_facet |
De Paiva,CS Pflugfelder,SC |
author_role |
author |
author2 |
Pflugfelder,SC |
author2_role |
author |
dc.contributor.author.fl_str_mv |
De Paiva,CS Pflugfelder,SC |
dc.subject.por.fl_str_mv |
Dry eye syndromes Inflammation Concentration osmolar Cyclosporine/therapeutic use Doxycycline/therapeutic use Cytokines/therapeutic use Metalloproteases Anti-Inflammatory agents/therapeutic use |
topic |
Dry eye syndromes Inflammation Concentration osmolar Cyclosporine/therapeutic use Doxycycline/therapeutic use Cytokines/therapeutic use Metalloproteases Anti-Inflammatory agents/therapeutic use |
description |
Dry eye is a multifactorial condition that results in a dysfunctional lacrimal functional unit. Evidence suggests that inflammation is involved in the pathogenesis of the disease. Changes in tear composition including increased cytokines, chemokines, metalloproteinases and the number of T cells in the conjunctiva are found in dry eye patients and in animal models. This inflammation is responsible in part for the irritation symptoms, ocular surface epithelial disease, and altered corneal epithelial barrier function in dry eye. There are several anti-inflammatory therapies for dry eye that target one or more of the inflammatory mediators/pathways that have been identified and are discussed in detail. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492008000700017 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492008000700017 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-27492008000700017 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Oftalmologia v.71 n.6 suppl.0 2008 reponame:Arquivos brasileiros de oftalmologia (Online) instname:Conselho Brasileiro de Oftalmologia (CBO) instacron:CBO |
instname_str |
Conselho Brasileiro de Oftalmologia (CBO) |
instacron_str |
CBO |
institution |
CBO |
reponame_str |
Arquivos brasileiros de oftalmologia (Online) |
collection |
Arquivos brasileiros de oftalmologia (Online) |
repository.name.fl_str_mv |
Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO) |
repository.mail.fl_str_mv |
aboonline@cbo.com.br||abo@cbo.com.br |
_version_ |
1754209025527906304 |