Evaluation of toxic retinopathy caused by antimalarial medications with spectral domain optical coherence tomography

Detalhes bibliográficos
Autor(a) principal: Cabral,Renata Tavares de Souza
Data de Publicação: 2019
Outros Autores: Klumb,Evandro Mendes, Couto,Maria Isabel Noronha Neta, Carneiro,Sueli
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos brasileiros de oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492019000100012
Resumo: ABSTRACT Purpose: To investigate the frequency of toxic retinopathy in patients with lupus erythematosus and rheumatoid arthritis with long-term use of chloroquine diphosphate or hydroxychloroquine through spectral domain optical coherence tomography and the outcomes of ophthalmological exams (visual acuity - Snellen’s table, color vision test - Ishihara’s table, fundoscopy, and retinography - red-free). Methods: A cross-sectional study was carried out involving the ophthalmologic evaluation of patients using regular chloroquine diphosphate or hydroxychloroquine for a period of 1 year or longer. The patients completed a questionnaire on their opinions and treatment regularity. The same patients underwent ophthalmologic examination and spectral domain optical coherence tomography. Results: The prevalence of toxic retinopathy caused by antimalarials was 4.15% (9 of 217 patients), 7.4% (4 of 54 patients) following chloroquine diphosphate usage, and 0.82% (1 of 121 patients) following hydroxychloroquine usage. Only patients with advanced stage maculopathy presented abnormalities during the ophthalmologic exam: the color vision test was altered in 11.1%, and visual acuity and fundoscopy were altered in 33.3%. Identification of early toxic retinopathy, detected in six patients, was possible using spectral domain optical coherence tomography. The mean duration of antimalarial drug usage among patients with toxic retinopathy was 10.4 years. Only 31% of the patients reported some symptoms during treatment, and although 24% were afraid to use the medication, they did so as prescribed. Conclusion: Use of spectral domain optical coherence tomography was essential for the diagnosis of early-stage antimalarial toxic retinopathy in patients with the following characteristics: asymptomatic, antimalarial use 7 days a week for a period of more than 5 years, and normal clinical ophthalmologic examination.
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spelling Evaluation of toxic retinopathy caused by antimalarial medications with spectral domain optical coherence tomographyRetinopathy/etiologyAntimalarials/adverse effectsHydroxychloroquine/adverse effectsChloroquine/adverse effectsTomography, optical coherence/methodsABSTRACT Purpose: To investigate the frequency of toxic retinopathy in patients with lupus erythematosus and rheumatoid arthritis with long-term use of chloroquine diphosphate or hydroxychloroquine through spectral domain optical coherence tomography and the outcomes of ophthalmological exams (visual acuity - Snellen’s table, color vision test - Ishihara’s table, fundoscopy, and retinography - red-free). Methods: A cross-sectional study was carried out involving the ophthalmologic evaluation of patients using regular chloroquine diphosphate or hydroxychloroquine for a period of 1 year or longer. The patients completed a questionnaire on their opinions and treatment regularity. The same patients underwent ophthalmologic examination and spectral domain optical coherence tomography. Results: The prevalence of toxic retinopathy caused by antimalarials was 4.15% (9 of 217 patients), 7.4% (4 of 54 patients) following chloroquine diphosphate usage, and 0.82% (1 of 121 patients) following hydroxychloroquine usage. Only patients with advanced stage maculopathy presented abnormalities during the ophthalmologic exam: the color vision test was altered in 11.1%, and visual acuity and fundoscopy were altered in 33.3%. Identification of early toxic retinopathy, detected in six patients, was possible using spectral domain optical coherence tomography. The mean duration of antimalarial drug usage among patients with toxic retinopathy was 10.4 years. Only 31% of the patients reported some symptoms during treatment, and although 24% were afraid to use the medication, they did so as prescribed. Conclusion: Use of spectral domain optical coherence tomography was essential for the diagnosis of early-stage antimalarial toxic retinopathy in patients with the following characteristics: asymptomatic, antimalarial use 7 days a week for a period of more than 5 years, and normal clinical ophthalmologic examination.Conselho Brasileiro de Oftalmologia2019-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492019000100012Arquivos Brasileiros de Oftalmologia v.82 n.1 2019reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.5935/0004-2749.20190002info:eu-repo/semantics/openAccessCabral,Renata Tavares de SouzaKlumb,Evandro MendesCouto,Maria Isabel Noronha NetaCarneiro,Suelieng2019-01-10T00:00:00Zoai:scielo:S0004-27492019000100012Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2019-01-10T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false
dc.title.none.fl_str_mv Evaluation of toxic retinopathy caused by antimalarial medications with spectral domain optical coherence tomography
title Evaluation of toxic retinopathy caused by antimalarial medications with spectral domain optical coherence tomography
spellingShingle Evaluation of toxic retinopathy caused by antimalarial medications with spectral domain optical coherence tomography
Cabral,Renata Tavares de Souza
Retinopathy/etiology
Antimalarials/adverse effects
Hydroxychloroquine/adverse effects
Chloroquine/adverse effects
Tomography, optical coherence/methods
title_short Evaluation of toxic retinopathy caused by antimalarial medications with spectral domain optical coherence tomography
title_full Evaluation of toxic retinopathy caused by antimalarial medications with spectral domain optical coherence tomography
title_fullStr Evaluation of toxic retinopathy caused by antimalarial medications with spectral domain optical coherence tomography
title_full_unstemmed Evaluation of toxic retinopathy caused by antimalarial medications with spectral domain optical coherence tomography
title_sort Evaluation of toxic retinopathy caused by antimalarial medications with spectral domain optical coherence tomography
author Cabral,Renata Tavares de Souza
author_facet Cabral,Renata Tavares de Souza
Klumb,Evandro Mendes
Couto,Maria Isabel Noronha Neta
Carneiro,Sueli
author_role author
author2 Klumb,Evandro Mendes
Couto,Maria Isabel Noronha Neta
Carneiro,Sueli
author2_role author
author
author
dc.contributor.author.fl_str_mv Cabral,Renata Tavares de Souza
Klumb,Evandro Mendes
Couto,Maria Isabel Noronha Neta
Carneiro,Sueli
dc.subject.por.fl_str_mv Retinopathy/etiology
Antimalarials/adverse effects
Hydroxychloroquine/adverse effects
Chloroquine/adverse effects
Tomography, optical coherence/methods
topic Retinopathy/etiology
Antimalarials/adverse effects
Hydroxychloroquine/adverse effects
Chloroquine/adverse effects
Tomography, optical coherence/methods
description ABSTRACT Purpose: To investigate the frequency of toxic retinopathy in patients with lupus erythematosus and rheumatoid arthritis with long-term use of chloroquine diphosphate or hydroxychloroquine through spectral domain optical coherence tomography and the outcomes of ophthalmological exams (visual acuity - Snellen’s table, color vision test - Ishihara’s table, fundoscopy, and retinography - red-free). Methods: A cross-sectional study was carried out involving the ophthalmologic evaluation of patients using regular chloroquine diphosphate or hydroxychloroquine for a period of 1 year or longer. The patients completed a questionnaire on their opinions and treatment regularity. The same patients underwent ophthalmologic examination and spectral domain optical coherence tomography. Results: The prevalence of toxic retinopathy caused by antimalarials was 4.15% (9 of 217 patients), 7.4% (4 of 54 patients) following chloroquine diphosphate usage, and 0.82% (1 of 121 patients) following hydroxychloroquine usage. Only patients with advanced stage maculopathy presented abnormalities during the ophthalmologic exam: the color vision test was altered in 11.1%, and visual acuity and fundoscopy were altered in 33.3%. Identification of early toxic retinopathy, detected in six patients, was possible using spectral domain optical coherence tomography. The mean duration of antimalarial drug usage among patients with toxic retinopathy was 10.4 years. Only 31% of the patients reported some symptoms during treatment, and although 24% were afraid to use the medication, they did so as prescribed. Conclusion: Use of spectral domain optical coherence tomography was essential for the diagnosis of early-stage antimalarial toxic retinopathy in patients with the following characteristics: asymptomatic, antimalarial use 7 days a week for a period of more than 5 years, and normal clinical ophthalmologic examination.
publishDate 2019
dc.date.none.fl_str_mv 2019-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492019000100012
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language eng
dc.relation.none.fl_str_mv 10.5935/0004-2749.20190002
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dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Oftalmologia v.82 n.1 2019
reponame:Arquivos brasileiros de oftalmologia (Online)
instname:Conselho Brasileiro de Oftalmologia (CBO)
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instname_str Conselho Brasileiro de Oftalmologia (CBO)
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reponame_str Arquivos brasileiros de oftalmologia (Online)
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repository.name.fl_str_mv Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)
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