Rangelia vitalii: changes in the enzymes ALT, CK and AST during the acute phase of experimental infection in dogs
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Parasitologia Veterinária (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612012000300012 |
Resumo: | Rangelia vitalii is a protozoon that causes diseases in dogs, and anemia is the most common laboratory finding. However, few studies on the biochemical changes in dogs infected with this protozoon exist. Thus, this study aimed to investigate the biochemical changes in dogs experimentally infected with R. vitalii, during the acute phase of the infection. For this study, 12 female dogs (aged 6-12 months and weighing between 4 and 7 kg) were used, divided in two groups. Group A was composed of healthy dogs (n = 5); and group B consisted of infected animals (n = 7). Blood samples were collected on days 0, 10, 20 and 30 after infection, using tubes without anticoagulant to obtain serum and analyze the biochemical parameters. An increase in alanine aminotransferase (ALT) on day 20 (P < 0.05) was observed. Also, increased creatine kinase (CK) and aspartate aminotransferase (AST) levels were observed throughout the experimental period (P < 0.05). No changes in the serum gamma-glutamyltransferase, urea and creatinine levels were observed. Thus, is possible to conclude that experimental infection with R. vitalii in dogs causes changes to the biochemical profile, with increased ALT, AST and CK enzyme levels. |
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Rangelia vitalii: changes in the enzymes ALT, CK and AST during the acute phase of experimental infection in dogsRangeliosiscreatine kinasealanine aminotransferaseaspartate aminotransferaseR. vitaliiRangelia vitalii is a protozoon that causes diseases in dogs, and anemia is the most common laboratory finding. However, few studies on the biochemical changes in dogs infected with this protozoon exist. Thus, this study aimed to investigate the biochemical changes in dogs experimentally infected with R. vitalii, during the acute phase of the infection. For this study, 12 female dogs (aged 6-12 months and weighing between 4 and 7 kg) were used, divided in two groups. Group A was composed of healthy dogs (n = 5); and group B consisted of infected animals (n = 7). Blood samples were collected on days 0, 10, 20 and 30 after infection, using tubes without anticoagulant to obtain serum and analyze the biochemical parameters. An increase in alanine aminotransferase (ALT) on day 20 (P < 0.05) was observed. Also, increased creatine kinase (CK) and aspartate aminotransferase (AST) levels were observed throughout the experimental period (P < 0.05). No changes in the serum gamma-glutamyltransferase, urea and creatinine levels were observed. Thus, is possible to conclude that experimental infection with R. vitalii in dogs causes changes to the biochemical profile, with increased ALT, AST and CK enzyme levels.Colégio Brasileiro de Parasitologia Veterinária2012-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612012000300012Revista Brasileira de Parasitologia Veterinária v.21 n.3 2012reponame:Revista Brasileira de Parasitologia Veterinária (Online)instname:Colégio Brasileiro de Parasitologia Veterinária (CBPV)instacron:CBPV10.1590/S1984-29612012000300012info:eu-repo/semantics/openAccessCosta,Márcio MachadoFrança,Raqueli TeresinhaDa Silva,Aleksandro SchaferPaim,Carlos BrenoPaim,FrancineAmaral,Carlos Henrique doDornelles,Guilherme LopesCunha,João Paulo Monteiro Carvalho Mori daSoares,João FabioLabruna,Marcelo BahiaMazzanti,Cinthia Melazzo AndradeMonteiro,Silvia GonzalezLopes,Sonia Terezinha dos Anjoseng2012-10-11T00:00:00Zoai:scielo:S1984-29612012000300012Revistahttp://www.scielo.br/scielo.php?script=sci_serial&lng=pt&pid=1984-2961https://old.scielo.br/oai/scielo-oai.php||zacariascbpv@fcav.unesp.br1984-29610103-846Xopendoar:2012-10-11T00:00Revista Brasileira de Parasitologia Veterinária (Online) - Colégio Brasileiro de Parasitologia Veterinária (CBPV)false |
dc.title.none.fl_str_mv |
Rangelia vitalii: changes in the enzymes ALT, CK and AST during the acute phase of experimental infection in dogs |
title |
Rangelia vitalii: changes in the enzymes ALT, CK and AST during the acute phase of experimental infection in dogs |
spellingShingle |
Rangelia vitalii: changes in the enzymes ALT, CK and AST during the acute phase of experimental infection in dogs Costa,Márcio Machado Rangeliosis creatine kinase alanine aminotransferase aspartate aminotransferase R. vitalii |
title_short |
Rangelia vitalii: changes in the enzymes ALT, CK and AST during the acute phase of experimental infection in dogs |
title_full |
Rangelia vitalii: changes in the enzymes ALT, CK and AST during the acute phase of experimental infection in dogs |
title_fullStr |
Rangelia vitalii: changes in the enzymes ALT, CK and AST during the acute phase of experimental infection in dogs |
title_full_unstemmed |
Rangelia vitalii: changes in the enzymes ALT, CK and AST during the acute phase of experimental infection in dogs |
title_sort |
Rangelia vitalii: changes in the enzymes ALT, CK and AST during the acute phase of experimental infection in dogs |
author |
Costa,Márcio Machado |
author_facet |
Costa,Márcio Machado França,Raqueli Teresinha Da Silva,Aleksandro Schafer Paim,Carlos Breno Paim,Francine Amaral,Carlos Henrique do Dornelles,Guilherme Lopes Cunha,João Paulo Monteiro Carvalho Mori da Soares,João Fabio Labruna,Marcelo Bahia Mazzanti,Cinthia Melazzo Andrade Monteiro,Silvia Gonzalez Lopes,Sonia Terezinha dos Anjos |
author_role |
author |
author2 |
França,Raqueli Teresinha Da Silva,Aleksandro Schafer Paim,Carlos Breno Paim,Francine Amaral,Carlos Henrique do Dornelles,Guilherme Lopes Cunha,João Paulo Monteiro Carvalho Mori da Soares,João Fabio Labruna,Marcelo Bahia Mazzanti,Cinthia Melazzo Andrade Monteiro,Silvia Gonzalez Lopes,Sonia Terezinha dos Anjos |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Costa,Márcio Machado França,Raqueli Teresinha Da Silva,Aleksandro Schafer Paim,Carlos Breno Paim,Francine Amaral,Carlos Henrique do Dornelles,Guilherme Lopes Cunha,João Paulo Monteiro Carvalho Mori da Soares,João Fabio Labruna,Marcelo Bahia Mazzanti,Cinthia Melazzo Andrade Monteiro,Silvia Gonzalez Lopes,Sonia Terezinha dos Anjos |
dc.subject.por.fl_str_mv |
Rangeliosis creatine kinase alanine aminotransferase aspartate aminotransferase R. vitalii |
topic |
Rangeliosis creatine kinase alanine aminotransferase aspartate aminotransferase R. vitalii |
description |
Rangelia vitalii is a protozoon that causes diseases in dogs, and anemia is the most common laboratory finding. However, few studies on the biochemical changes in dogs infected with this protozoon exist. Thus, this study aimed to investigate the biochemical changes in dogs experimentally infected with R. vitalii, during the acute phase of the infection. For this study, 12 female dogs (aged 6-12 months and weighing between 4 and 7 kg) were used, divided in two groups. Group A was composed of healthy dogs (n = 5); and group B consisted of infected animals (n = 7). Blood samples were collected on days 0, 10, 20 and 30 after infection, using tubes without anticoagulant to obtain serum and analyze the biochemical parameters. An increase in alanine aminotransferase (ALT) on day 20 (P < 0.05) was observed. Also, increased creatine kinase (CK) and aspartate aminotransferase (AST) levels were observed throughout the experimental period (P < 0.05). No changes in the serum gamma-glutamyltransferase, urea and creatinine levels were observed. Thus, is possible to conclude that experimental infection with R. vitalii in dogs causes changes to the biochemical profile, with increased ALT, AST and CK enzyme levels. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612012000300012 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612012000300012 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1984-29612012000300012 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Parasitologia Veterinária |
publisher.none.fl_str_mv |
Colégio Brasileiro de Parasitologia Veterinária |
dc.source.none.fl_str_mv |
Revista Brasileira de Parasitologia Veterinária v.21 n.3 2012 reponame:Revista Brasileira de Parasitologia Veterinária (Online) instname:Colégio Brasileiro de Parasitologia Veterinária (CBPV) instacron:CBPV |
instname_str |
Colégio Brasileiro de Parasitologia Veterinária (CBPV) |
instacron_str |
CBPV |
institution |
CBPV |
reponame_str |
Revista Brasileira de Parasitologia Veterinária (Online) |
collection |
Revista Brasileira de Parasitologia Veterinária (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Parasitologia Veterinária (Online) - Colégio Brasileiro de Parasitologia Veterinária (CBPV) |
repository.mail.fl_str_mv |
||zacariascbpv@fcav.unesp.br |
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1754208914386190336 |