Vertical transmission of Toxocara canis in successive generations of mice

Detalhes bibliográficos
Autor(a) principal: Schoenardie,Elizandra Roselaine
Data de Publicação: 2013
Outros Autores: Scaini,Carlos James, Pepe,Michele Soares, Borsuk,Sibele, Avila,Luciana Farias da Costa de, Villela,Marcos, Berne,Maria Elisabeth Aires
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Parasitologia Veterinária (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612013000400623
Resumo: Visceral toxocariasis is a neglected zoonosis caused by Toxocara canis larvae in unusual hosts. In dogs, the definitive host, the infection occurs mainly through transplacental and transcolostral transmission. Studies on experimental models have shown that vertical transmission may result from acute infections. Considering that toxocariasis is characterized as a chronic infection, with possible reactivation of larvae present in the brain, this study evaluated the presence of larvae in the brain of female BALB/c mice and their offspring with chronic infection during three successive pregnancies. ELISA-TES was used to evaluate the antibody levels. T. canis larvae were detected in the brain tissue of the mice during the three successive generations evaluated. The offspring's IgG level gradually decreased, and mean absorbance (ABS) above the cutoff point (0.070) was observed only at 30 (0.229) and 50 (0.096) days of age, while IgM was not detected. The infections in the offspring confirmed that vertical transmission of T. canis larvae occurred during chronic toxocariasis in three successive generations of mice.
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spelling Vertical transmission of Toxocara canis in successive generations of miceVisceral larva migransToxocara canisvertical transmissionBALB/c miceELISA - TESVisceral toxocariasis is a neglected zoonosis caused by Toxocara canis larvae in unusual hosts. In dogs, the definitive host, the infection occurs mainly through transplacental and transcolostral transmission. Studies on experimental models have shown that vertical transmission may result from acute infections. Considering that toxocariasis is characterized as a chronic infection, with possible reactivation of larvae present in the brain, this study evaluated the presence of larvae in the brain of female BALB/c mice and their offspring with chronic infection during three successive pregnancies. ELISA-TES was used to evaluate the antibody levels. T. canis larvae were detected in the brain tissue of the mice during the three successive generations evaluated. The offspring's IgG level gradually decreased, and mean absorbance (ABS) above the cutoff point (0.070) was observed only at 30 (0.229) and 50 (0.096) days of age, while IgM was not detected. The infections in the offspring confirmed that vertical transmission of T. canis larvae occurred during chronic toxocariasis in three successive generations of mice.Colégio Brasileiro de Parasitologia Veterinária2013-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612013000400623Revista Brasileira de Parasitologia Veterinária v.22 n.4 2013reponame:Revista Brasileira de Parasitologia Veterinária (Online)instname:Colégio Brasileiro de Parasitologia Veterinária (CBPV)instacron:CBPV10.1590/S1984-29612013000400030info:eu-repo/semantics/openAccessSchoenardie,Elizandra RoselaineScaini,Carlos JamesPepe,Michele SoaresBorsuk,SibeleAvila,Luciana Farias da Costa deVillela,MarcosBerne,Maria Elisabeth Aireseng2015-11-24T00:00:00Zoai:scielo:S1984-29612013000400623Revistahttp://www.scielo.br/scielo.php?script=sci_serial&lng=pt&pid=1984-2961https://old.scielo.br/oai/scielo-oai.php||zacariascbpv@fcav.unesp.br1984-29610103-846Xopendoar:2015-11-24T00:00Revista Brasileira de Parasitologia Veterinária (Online) - Colégio Brasileiro de Parasitologia Veterinária (CBPV)false
dc.title.none.fl_str_mv Vertical transmission of Toxocara canis in successive generations of mice
title Vertical transmission of Toxocara canis in successive generations of mice
spellingShingle Vertical transmission of Toxocara canis in successive generations of mice
Schoenardie,Elizandra Roselaine
Visceral larva migrans
Toxocara canis
vertical transmission
BALB/c mice
ELISA - TES
title_short Vertical transmission of Toxocara canis in successive generations of mice
title_full Vertical transmission of Toxocara canis in successive generations of mice
title_fullStr Vertical transmission of Toxocara canis in successive generations of mice
title_full_unstemmed Vertical transmission of Toxocara canis in successive generations of mice
title_sort Vertical transmission of Toxocara canis in successive generations of mice
author Schoenardie,Elizandra Roselaine
author_facet Schoenardie,Elizandra Roselaine
Scaini,Carlos James
Pepe,Michele Soares
Borsuk,Sibele
Avila,Luciana Farias da Costa de
Villela,Marcos
Berne,Maria Elisabeth Aires
author_role author
author2 Scaini,Carlos James
Pepe,Michele Soares
Borsuk,Sibele
Avila,Luciana Farias da Costa de
Villela,Marcos
Berne,Maria Elisabeth Aires
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Schoenardie,Elizandra Roselaine
Scaini,Carlos James
Pepe,Michele Soares
Borsuk,Sibele
Avila,Luciana Farias da Costa de
Villela,Marcos
Berne,Maria Elisabeth Aires
dc.subject.por.fl_str_mv Visceral larva migrans
Toxocara canis
vertical transmission
BALB/c mice
ELISA - TES
topic Visceral larva migrans
Toxocara canis
vertical transmission
BALB/c mice
ELISA - TES
description Visceral toxocariasis is a neglected zoonosis caused by Toxocara canis larvae in unusual hosts. In dogs, the definitive host, the infection occurs mainly through transplacental and transcolostral transmission. Studies on experimental models have shown that vertical transmission may result from acute infections. Considering that toxocariasis is characterized as a chronic infection, with possible reactivation of larvae present in the brain, this study evaluated the presence of larvae in the brain of female BALB/c mice and their offspring with chronic infection during three successive pregnancies. ELISA-TES was used to evaluate the antibody levels. T. canis larvae were detected in the brain tissue of the mice during the three successive generations evaluated. The offspring's IgG level gradually decreased, and mean absorbance (ABS) above the cutoff point (0.070) was observed only at 30 (0.229) and 50 (0.096) days of age, while IgM was not detected. The infections in the offspring confirmed that vertical transmission of T. canis larvae occurred during chronic toxocariasis in three successive generations of mice.
publishDate 2013
dc.date.none.fl_str_mv 2013-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612013000400623
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612013000400623
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1984-29612013000400030
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Colégio Brasileiro de Parasitologia Veterinária
publisher.none.fl_str_mv Colégio Brasileiro de Parasitologia Veterinária
dc.source.none.fl_str_mv Revista Brasileira de Parasitologia Veterinária v.22 n.4 2013
reponame:Revista Brasileira de Parasitologia Veterinária (Online)
instname:Colégio Brasileiro de Parasitologia Veterinária (CBPV)
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instname_str Colégio Brasileiro de Parasitologia Veterinária (CBPV)
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collection Revista Brasileira de Parasitologia Veterinária (Online)
repository.name.fl_str_mv Revista Brasileira de Parasitologia Veterinária (Online) - Colégio Brasileiro de Parasitologia Veterinária (CBPV)
repository.mail.fl_str_mv ||zacariascbpv@fcav.unesp.br
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