Differences in negative predictive value of prostate MRI based in men with suspected or known cancer

Detalhes bibliográficos
Autor(a) principal: Baghdanian,Armonde A.
Data de Publicação: 2019
Outros Autores: Kim,Yoon-Jin, Baghdanian,Arthur H., Nguyen,Hao N., Shinohara,Katsuto, Westphalen,Antonio C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Radiologia Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842019000500281
Resumo: Abstract Objective: To compare the negative predictive value (NPV) of multiparametric MRI for Gleason score (GS) ≥ 3+4 cancer and evaluate predictors of these tumors in men with suspected disease and under active surveillance (AS). Materials and Methods: This retrospective study included 38 men with suspected prostate cancer and 38 under AS with scans assigned PI-RADS v2 scores 1 or 2 between May 2016 and September 2017. Biopsy results were no cancer, GS = 3+3, or GS ≥ 3+4. Pre-MRI PSA, gland volume, and PSA density were recorded. Chi-square, equality of proportions, and logistic regressions were used to analyze the data. Results: Intermediate to high-grade cancer was found in 12.8% (95% CI = 2.3-23.3) and 35.9% (95% CI = 20.8-50.9) of men with suspected cancer, and under AS (p = 0.02), respectively. The NPV for GS ≥ 3+4 were 87.2% (suspected cancer; 76.7-97.7) and 64.1% (AS; 49.0-79.2). In neither group PSA significantly predicted cancer grade (p = 0.75 and 0.63). Although it did not reach conventional statistical significance, PSA density was a good predictor of cancer grade in men with suspected disease (p = 0.06), but not under AS (p = 0.62). Conclusion: The NPV of multiparametric MRI for GS ≥ 3+4 is higher in men with suspected prostate cancer than in men under AS. PSA density ≤ 0.15 improved the prediction of intermediate to high-grade disease in patients without known cancer.
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spelling Differences in negative predictive value of prostate MRI based in men with suspected or known cancerProstate cancerActive surveillanceMagnetic resonance imagingProstate biopsyMultiparametric MRIAbstract Objective: To compare the negative predictive value (NPV) of multiparametric MRI for Gleason score (GS) ≥ 3+4 cancer and evaluate predictors of these tumors in men with suspected disease and under active surveillance (AS). Materials and Methods: This retrospective study included 38 men with suspected prostate cancer and 38 under AS with scans assigned PI-RADS v2 scores 1 or 2 between May 2016 and September 2017. Biopsy results were no cancer, GS = 3+3, or GS ≥ 3+4. Pre-MRI PSA, gland volume, and PSA density were recorded. Chi-square, equality of proportions, and logistic regressions were used to analyze the data. Results: Intermediate to high-grade cancer was found in 12.8% (95% CI = 2.3-23.3) and 35.9% (95% CI = 20.8-50.9) of men with suspected cancer, and under AS (p = 0.02), respectively. The NPV for GS ≥ 3+4 were 87.2% (suspected cancer; 76.7-97.7) and 64.1% (AS; 49.0-79.2). In neither group PSA significantly predicted cancer grade (p = 0.75 and 0.63). Although it did not reach conventional statistical significance, PSA density was a good predictor of cancer grade in men with suspected disease (p = 0.06), but not under AS (p = 0.62). Conclusion: The NPV of multiparametric MRI for GS ≥ 3+4 is higher in men with suspected prostate cancer than in men under AS. PSA density ≤ 0.15 improved the prediction of intermediate to high-grade disease in patients without known cancer.Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem2019-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842019000500281Radiologia Brasileira v.52 n.5 2019reponame:Radiologia Brasileira (Online)instname:Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR)instacron:CBR10.1590/0100-3984.2018.0126info:eu-repo/semantics/openAccessBaghdanian,Armonde A.Kim,Yoon-JinBaghdanian,Arthur H.Nguyen,Hao N.Shinohara,KatsutoWestphalen,Antonio C.eng2019-10-21T00:00:00Zoai:scielo:S0100-39842019000500281Revistahttps://www.scielo.br/j/rb/https://old.scielo.br/oai/scielo-oai.phpradiologiabrasileira@cbr.org.br1678-70990100-3984opendoar:2019-10-21T00:00Radiologia Brasileira (Online) - Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR)false
dc.title.none.fl_str_mv Differences in negative predictive value of prostate MRI based in men with suspected or known cancer
title Differences in negative predictive value of prostate MRI based in men with suspected or known cancer
spellingShingle Differences in negative predictive value of prostate MRI based in men with suspected or known cancer
Baghdanian,Armonde A.
Prostate cancer
Active surveillance
Magnetic resonance imaging
Prostate biopsy
Multiparametric MRI
title_short Differences in negative predictive value of prostate MRI based in men with suspected or known cancer
title_full Differences in negative predictive value of prostate MRI based in men with suspected or known cancer
title_fullStr Differences in negative predictive value of prostate MRI based in men with suspected or known cancer
title_full_unstemmed Differences in negative predictive value of prostate MRI based in men with suspected or known cancer
title_sort Differences in negative predictive value of prostate MRI based in men with suspected or known cancer
author Baghdanian,Armonde A.
author_facet Baghdanian,Armonde A.
Kim,Yoon-Jin
Baghdanian,Arthur H.
Nguyen,Hao N.
Shinohara,Katsuto
Westphalen,Antonio C.
author_role author
author2 Kim,Yoon-Jin
Baghdanian,Arthur H.
Nguyen,Hao N.
Shinohara,Katsuto
Westphalen,Antonio C.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Baghdanian,Armonde A.
Kim,Yoon-Jin
Baghdanian,Arthur H.
Nguyen,Hao N.
Shinohara,Katsuto
Westphalen,Antonio C.
dc.subject.por.fl_str_mv Prostate cancer
Active surveillance
Magnetic resonance imaging
Prostate biopsy
Multiparametric MRI
topic Prostate cancer
Active surveillance
Magnetic resonance imaging
Prostate biopsy
Multiparametric MRI
description Abstract Objective: To compare the negative predictive value (NPV) of multiparametric MRI for Gleason score (GS) ≥ 3+4 cancer and evaluate predictors of these tumors in men with suspected disease and under active surveillance (AS). Materials and Methods: This retrospective study included 38 men with suspected prostate cancer and 38 under AS with scans assigned PI-RADS v2 scores 1 or 2 between May 2016 and September 2017. Biopsy results were no cancer, GS = 3+3, or GS ≥ 3+4. Pre-MRI PSA, gland volume, and PSA density were recorded. Chi-square, equality of proportions, and logistic regressions were used to analyze the data. Results: Intermediate to high-grade cancer was found in 12.8% (95% CI = 2.3-23.3) and 35.9% (95% CI = 20.8-50.9) of men with suspected cancer, and under AS (p = 0.02), respectively. The NPV for GS ≥ 3+4 were 87.2% (suspected cancer; 76.7-97.7) and 64.1% (AS; 49.0-79.2). In neither group PSA significantly predicted cancer grade (p = 0.75 and 0.63). Although it did not reach conventional statistical significance, PSA density was a good predictor of cancer grade in men with suspected disease (p = 0.06), but not under AS (p = 0.62). Conclusion: The NPV of multiparametric MRI for GS ≥ 3+4 is higher in men with suspected prostate cancer than in men under AS. PSA density ≤ 0.15 improved the prediction of intermediate to high-grade disease in patients without known cancer.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842019000500281
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842019000500281
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0100-3984.2018.0126
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem
publisher.none.fl_str_mv Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem
dc.source.none.fl_str_mv Radiologia Brasileira v.52 n.5 2019
reponame:Radiologia Brasileira (Online)
instname:Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR)
instacron:CBR
instname_str Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR)
instacron_str CBR
institution CBR
reponame_str Radiologia Brasileira (Online)
collection Radiologia Brasileira (Online)
repository.name.fl_str_mv Radiologia Brasileira (Online) - Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR)
repository.mail.fl_str_mv radiologiabrasileira@cbr.org.br
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