Development of nanogel from Copaifera reticulata on muscle lesions in rates with phonophoresis

• Autor(a) principal: Lima, Tamyres Carla Porteglio de
• Data de Publicação: 2020
• Outros Autores: Almeida, Amanda Furtado de, Pacheco de Oliveira, Elaine Cristina, Silva Júnior, José Otávio Carrera, Ribeiro Costa, Roseane Maria, Matos, Areolino Pena, Gomes, Madson Ralide Fonseca
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Saúde e Pesquisa (Online)
• Texto Completo: https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/7518
• topic: Phonophoresis; Medicinal plants; Muscle fatigue; Pharmacokinetics; Fonoforese; Lesão muscular esquelética; Nanoemulsão; Óleo copaiba; Óleo-resina.; Nanotecnologia

Copaifera reticulata Ducke is a medicinal plants greatly employed in northern and northeastern Brazil. However, skin penetration is difficult when it is applied in natura. However, permeability increases through nanoformulations and phonophoresis and low frequency ultrasound that increases skin permeability of compounds. The effect of oil-resin of copaiba, in natura and in gel (nano-emulsion), associated to phonophoresis, was analyzed and compared for muscle repair in Wistar rats. Copaiba nano-emulsion was formulated by phase inversion. It was incorporated to hydrogel Carbopol® (20% nano-emulsion, 80% Carbopol®). Male animals (n=24) were divided into six groups and later underwent traumatic lesion of the gastrocnemius muscle. Muscle repair was analyzed by plasmatic dosage of aspartate aminotransferase (AST) and kinase creatine (CK). Results show that topic treatments with oil-resin, associated with phonophoresis and nanogel were efficient in the assay for the repair of skeleton muscles.