Spontaneous cytokine production in children according to biological characteristics and environmental exposures.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8299 |
Resumo: | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil |
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Figueiredo, Camila Alexandrina VianaNeves, Neuza Maria AlcântaraVeiga, Rafael ValenteAmorim, Leila DDattoli, Vitor Camilo CavalcanteMendonça, Lívia RibeiroJunqueira, Samuel BadaróGenser, BerndSantos, MariesePontes-de-Carvalho, Lain CarlosCooper, Philip JohnRodrigues, Laura CunhaBarreto, Maurício Lima2014-09-01T19:27:26Z2014-09-01T19:27:26Z2009FIGUEIREDO, C. A. et al. Spontaneous cytokine production in children according to biological characteristics and environmental exposures. Environmental Health Perspectives, v. 117, n. 5, p. 845-849, 2009.1552-9924https://www.arca.fiocruz.br/handle/icict/829910.1289/ehp.0800366engNational Institute of Environmental Health SciencesSpontaneous cytokine production in children according to biological characteristics and environmental exposures.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Matemática. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Matemática. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidad San Francisco de Quito. Quito, EcuadorLondon School of Hygiene and Tropical Medicine. London, United KingdomUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilBACKGROUND: Environmental factors are likely to have profound effects on the development of host immune responses, with serious implications for infectious diseases and inflammatory disorders such as asthma. OBJECTIVE: This study was designed to investigate the effects of environmental exposures on the cytokine profile of children. METHODS: The study involved measurement of T helper (Th) 1 (interferon-gamma), 2 [interleukin (IL)-5 and IL-13], and the regulatory cytokine IL-10 in unstimulated peripheral blood leukocytes from 1,376 children 4-11 years of age living in a poor urban area of the tropics. We also assessed the impact of environmental exposures in addition to biological characteristics recorded at the time of blood collection and earlier in childhood (0-3 years before blood collection). RESULTS: The proportion of children producing IL-10 was greater among those without access to drinking water [p < 0.05, chi-square test, odds ratio (OR) = 1.67]. The proportion of children producing IL-5 and IL-10 (OR = 10.76) was significantly greater in households that had never had a sewage system (p < 0.05, trend test). CONCLUSIONS: These data provide evidence for the profound effects of environmental exposures in early life as well as immune homeostasis in later childhood. Decreased hygiene (lack of access to clean drinking water and sanitation) in the first 3 years of life is associated with higher spontaneous IL-10 production up to 8 years later in life.AgeBreast-feedingCytokine profileIL-10SCAALAewageSexTap waterExposição AmbientalPoluentes Ambientais/toxicidadeSistema Imunológico/efeitos de drogasInterferon gama/sangueInterleucina-10/sangueFatores EtáriosCriançaPré-EscolarFemininoHumanosMasculinoEsgotos/efeitos adversosAbastecimento de Águainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8299/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALFigueiredo C A Spontaneous Cytokine....pdfFigueiredo C A Spontaneous Cytokine....pdfapplication/pdf378370https://www.arca.fiocruz.br/bitstream/icict/8299/2/Figueiredo%20C%20A%20Spontaneous%20Cytokine....pdf60be36f7536a3300cded61effe2d7c25MD52TEXTFigueiredo C A Spontaneous Cytokine....pdf.txtFigueiredo C A Spontaneous Cytokine....pdf.txtExtracted texttext/plain40133https://www.arca.fiocruz.br/bitstream/icict/8299/3/Figueiredo%20C%20A%20Spontaneous%20Cytokine....pdf.txt0ee717edb70fbd9d6c9f81d347dbc55cMD53icict/82992023-03-15 14:33:05.865oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:05Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Spontaneous cytokine production in children according to biological characteristics and environmental exposures. |
| title |
Spontaneous cytokine production in children according to biological characteristics and environmental exposures. |
| spellingShingle |
Spontaneous cytokine production in children according to biological characteristics and environmental exposures. Figueiredo, Camila Alexandrina Viana Age Breast-feeding Cytokine profile IL-10 SCAALA ewage Sex Tap water Exposição Ambiental Poluentes Ambientais/toxicidade Sistema Imunológico/efeitos de drogas Interferon gama/sangue Interleucina-10/sangue Fatores Etários Criança Pré-Escolar Feminino Humanos Masculino Esgotos/efeitos adversos Abastecimento de Água |
| title_short |
Spontaneous cytokine production in children according to biological characteristics and environmental exposures. |
| title_full |
Spontaneous cytokine production in children according to biological characteristics and environmental exposures. |
| title_fullStr |
Spontaneous cytokine production in children according to biological characteristics and environmental exposures. |
| title_full_unstemmed |
Spontaneous cytokine production in children according to biological characteristics and environmental exposures. |
| title_sort |
Spontaneous cytokine production in children according to biological characteristics and environmental exposures. |
| author |
Figueiredo, Camila Alexandrina Viana |
| author_facet |
Figueiredo, Camila Alexandrina Viana Neves, Neuza Maria Alcântara Veiga, Rafael Valente Amorim, Leila D Dattoli, Vitor Camilo Cavalcante Mendonça, Lívia Ribeiro Junqueira, Samuel Badaró Genser, Bernd Santos, Mariese Pontes-de-Carvalho, Lain Carlos Cooper, Philip John Rodrigues, Laura Cunha Barreto, Maurício Lima |
| author_role |
author |
| author2 |
Neves, Neuza Maria Alcântara Veiga, Rafael Valente Amorim, Leila D Dattoli, Vitor Camilo Cavalcante Mendonça, Lívia Ribeiro Junqueira, Samuel Badaró Genser, Bernd Santos, Mariese Pontes-de-Carvalho, Lain Carlos Cooper, Philip John Rodrigues, Laura Cunha Barreto, Maurício Lima |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Figueiredo, Camila Alexandrina Viana Neves, Neuza Maria Alcântara Veiga, Rafael Valente Amorim, Leila D Dattoli, Vitor Camilo Cavalcante Mendonça, Lívia Ribeiro Junqueira, Samuel Badaró Genser, Bernd Santos, Mariese Pontes-de-Carvalho, Lain Carlos Cooper, Philip John Rodrigues, Laura Cunha Barreto, Maurício Lima |
| dc.subject.en.pt_BR.fl_str_mv |
Age Breast-feeding Cytokine profile IL-10 SCAALA ewage Sex Tap water |
| topic |
Age Breast-feeding Cytokine profile IL-10 SCAALA ewage Sex Tap water Exposição Ambiental Poluentes Ambientais/toxicidade Sistema Imunológico/efeitos de drogas Interferon gama/sangue Interleucina-10/sangue Fatores Etários Criança Pré-Escolar Feminino Humanos Masculino Esgotos/efeitos adversos Abastecimento de Água |
| dc.subject.decs.pt_BR.fl_str_mv |
Exposição Ambiental Poluentes Ambientais/toxicidade Sistema Imunológico/efeitos de drogas Interferon gama/sangue Interleucina-10/sangue Fatores Etários Criança Pré-Escolar Feminino Humanos Masculino Esgotos/efeitos adversos Abastecimento de Água |
| description |
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil |
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2009 |
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2009 |
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2014-09-01T19:27:26Z |
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2014-09-01T19:27:26Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
FIGUEIREDO, C. A. et al. Spontaneous cytokine production in children according to biological characteristics and environmental exposures. Environmental Health Perspectives, v. 117, n. 5, p. 845-849, 2009. |
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https://www.arca.fiocruz.br/handle/icict/8299 |
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1552-9924 |
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10.1289/ehp.0800366 |
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FIGUEIREDO, C. A. et al. Spontaneous cytokine production in children according to biological characteristics and environmental exposures. Environmental Health Perspectives, v. 117, n. 5, p. 845-849, 2009. 1552-9924 10.1289/ehp.0800366 |
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National Institute of Environmental Health Sciences |
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National Institute of Environmental Health Sciences |
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