The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18830 |
Resumo: | Institute of Integral Medicine Professor Fernando Figueira (IMIP). Pediatrics. Recife, PE, Brazil. |
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Brito, Rita de Cássia Coelho Moraes deLucena-Silva, NormaTorres, Leuridan CavalcanteLuna, Carlos FeitosaCorreia, Jaílson de BarrosSilva, Giselia Alves Pontes da2017-05-11T17:51:49Z2017-05-11T17:51:49Z2016BRITO, R. DE C. C. M. de et al. The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia. BMC Pulmonary Medicine, v. 16, n. 1, dez. 2016.1471-2466https://www.arca.fiocruz.br/handle/icict/1883010.1186/s12890-016-0324-zengThe balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumoniainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstitute of Integral Medicine Professor Fernando Figueira (IMIP). Pediatrics. Recife, PE, Brazil.Institute of Integral Medicine Professor Fernando Figueira (IMIP). Oncology and Aggeu Magalhães Research Center. Fiocruz-PE. Immunology. Recife, PE, Brazil.Institute of Integral Medicine Professor Fernando Figueira ( IMIP). Translational Medicine Laboratory. Recife, PE, Brazil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Saúde Pública. Recife, PE, Brasil.Institute of Integral Medicine Professor Fernando Figueira ( IMIP). Translational Medicine Laboratory. Recife, PE, Brazil.Federal University of Pernambuco. Pediatrics. Recife, PE, Brazil.Background: To identify markers for earlier diagnosis of severe pneumonia, we assess the correlation between serum cytokine profile of children with different pneumonia severity. Methods: In 25 hospitalized children, 7 with mild pneumonia and 18 with severe pneumonia, the serum concentration of 11 cytokines in three sampling times were dosed. Statistical analysis included parametric and non-parametric tests, Pearson correlation and ROC curve for cut-off definition of cytokines. Results: At admission, IL-6 serum levels were high in mild or severe pneumonia, and was associated to vomiting (P = 0. 019) in both groups; and also to dyspnea (P = 0.012) and white blood cell count (P = 0.045) in patients with severe pneumonia. IL-10 levels were also high in patients with pneumonia and were associated to lymphocytosis (P = 0.025). The ROC curve of the IL-6:IL-10 serum levels ratio discriminated severe pneumonia cases at admission, and persistence of infection in the third day of antibiotic therapy, with positive predictive values of 93% and 89%, respectively. Conclusions: The balance between IL-6 and IL-10 serum levels showed to be a more discriminative marker for severity definition and evaluation of recovery in patients with pneumonia.Interleucina-10 / sanguePneumonia / sangueContagem de LeucócitosBiomarcadores / sangueEstudos Prospectivosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18830/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINAL27905908 2016 bri-bal.pdf27905908 2016 bri-bal.pdfapplication/pdf546697https://www.arca.fiocruz.br/bitstream/icict/18830/2/27905908%202016%20bri-bal.pdf4701d46965e36c5febc1184f27087bdaMD52TEXT27905908 2016 bri-bal.pdf.txt27905908 2016 bri-bal.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia |
| title |
The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia |
| spellingShingle |
The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia Brito, Rita de Cássia Coelho Moraes de Interleucina-10 / sangue Pneumonia / sangue Contagem de Leucócitos Biomarcadores / sangue Estudos Prospectivos |
| title_short |
The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia |
| title_full |
The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia |
| title_fullStr |
The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia |
| title_full_unstemmed |
The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia |
| title_sort |
The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia |
| author |
Brito, Rita de Cássia Coelho Moraes de |
| author_facet |
Brito, Rita de Cássia Coelho Moraes de Lucena-Silva, Norma Torres, Leuridan Cavalcante Luna, Carlos Feitosa Correia, Jaílson de Barros Silva, Giselia Alves Pontes da |
| author_role |
author |
| author2 |
Lucena-Silva, Norma Torres, Leuridan Cavalcante Luna, Carlos Feitosa Correia, Jaílson de Barros Silva, Giselia Alves Pontes da |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Brito, Rita de Cássia Coelho Moraes de Lucena-Silva, Norma Torres, Leuridan Cavalcante Luna, Carlos Feitosa Correia, Jaílson de Barros Silva, Giselia Alves Pontes da |
| dc.subject.decs.none.fl_str_mv |
Interleucina-10 / sangue Pneumonia / sangue Contagem de Leucócitos Biomarcadores / sangue Estudos Prospectivos |
| topic |
Interleucina-10 / sangue Pneumonia / sangue Contagem de Leucócitos Biomarcadores / sangue Estudos Prospectivos |
| description |
Institute of Integral Medicine Professor Fernando Figueira (IMIP). Pediatrics. Recife, PE, Brazil. |
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2016 |
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2016 |
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2017-05-11T17:51:49Z |
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2017-05-11T17:51:49Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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BRITO, R. DE C. C. M. de et al. The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia. BMC Pulmonary Medicine, v. 16, n. 1, dez. 2016. |
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https://www.arca.fiocruz.br/handle/icict/18830 |
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1471-2466 |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.1186/s12890-016-0324-z |
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BRITO, R. DE C. C. M. de et al. The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia. BMC Pulmonary Medicine, v. 16, n. 1, dez. 2016. 1471-2466 10.1186/s12890-016-0324-z |
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