Antigen-specific Immunosuppression in Visceral Leishmaniasis Is Cell Mediated

Detalhes bibliográficos
Autor(a) principal: Carvalho, Edgar Marcelino de
Data de Publicação: 1989
Outros Autores: Bacellar, Maria Olívia Amado Ramos, Barral, Aldina Maria Prado, Badaró, Roberto José da Silva, Johnson Junior, Warren D
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/22869
Resumo: Barral, Aldina Maria Prado. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Carvalho, Edgar Marcelino deBacellar, Maria Olívia Amado RamosBarral, Aldina Maria PradoBadaró, Roberto José da SilvaJohnson Junior, Warren D2017-10-18T17:04:39Z2017-10-18T17:04:39Z1989CARVALHO, E. M. et al. Antigen-specific Immunosuppression in Visceral Leishmaniasis Is Cell Mediated. Journal of Clinical Investigation, v. 83, n. 3, p. 860-864, 1989.0021-9738https://www.arca.fiocruz.br/handle/icict/22869Barral, Aldina Maria Prado. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.AI-16282 from the National Institute of Allergy and Infectious Diseases and by the UNDP/World Bank/World Health Organization Special Program for Research and Training in Tropical Diseases and by the Brazilian Research Council (CNPq).University of Bahia. Department of Medicine. Division of Immunology. Salvador, BA, BrasilUniversity of Bahia. Department of Medicine. Division of Immunology. Salvador, BA, BrasilUniversity of Bahia. Department of Medicine. Division of Immunology. Salvador, BA, BrasilUniversity of Bahia. Department of Medicine. Division of Immunology. Salvador, BA, BrasilCornell University Medical College. Department of Medicine. Division of International Medicine.New York, USAVisceral leishmaniasis is associated with an antigen-specific immunosuppression during the acute disease. Patients become responsive- to Leishmania antigen in both in vivo and in vitro assays after successful antimony therapy. The cell type involved in the suppression of lymphocyte reactivity to Leishmania antigen was studied by selective depletion of mononuclear cell (MNC) populations and in co-cultivation experiments. Adherent cells were depleted on plastic and by passage on nylon wool columns. High-avidity Fc' cells were depleted by adherence to BSA-anti-BSA complexes and OKT4' and OKT8+ cells were depleted by treatment with monoclonal antibody (anti-OKT4' and OKT8) and complement. Depletion of MNC preparations of adherent cells, high-avidity Fc' cells, OKT4+ cells and OKT8+ cells failed to restore the lymphocyte reactivity to Leishmania antigen. Antimony therapy was assodiated with restoration of the proliferative responses of unseparated MNC (before treatment 460±76 cpm and after treatment 4,293±1,442 cpm). Co-culture of frozen cells obtained before chemotherapy with autologous MNC obtained after treatment reduced the response of posttreatment cells to Leishmania antigen by 80%. We conclude that the antigenic specific suppression of lymphocyte proliferation in visceral leishmaniasis is cell mediated.engAmerican Society for Clinical InvestigationLeishmaniose visceralLeishmaniaCélulasImunossupressãoLeishmaniasis visceralLeishmaniaCellImmunosuppressionAntigen-specific Immunosuppression in Visceral Leishmaniasis Is Cell Mediatedinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/22869/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCarvalho EM Antigenic-specific....pdfCarvalho EM Antigenic-specific....pdfapplication/pdf1145227https://www.arca.fiocruz.br/bitstream/icict/22869/2/Carvalho%20EM%20Antigenic-specific....pdfc04a10cae2ff125840ab9cea2a4209fbMD52TEXTCarvalho EM 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dc.title.pt_BR.fl_str_mv Antigen-specific Immunosuppression in Visceral Leishmaniasis Is Cell Mediated
title Antigen-specific Immunosuppression in Visceral Leishmaniasis Is Cell Mediated
spellingShingle Antigen-specific Immunosuppression in Visceral Leishmaniasis Is Cell Mediated
Carvalho, Edgar Marcelino de
Leishmaniose visceral
Leishmania
Células
Imunossupressão
Leishmaniasis visceral
Leishmania
Cell
Immunosuppression
title_short Antigen-specific Immunosuppression in Visceral Leishmaniasis Is Cell Mediated
title_full Antigen-specific Immunosuppression in Visceral Leishmaniasis Is Cell Mediated
title_fullStr Antigen-specific Immunosuppression in Visceral Leishmaniasis Is Cell Mediated
title_full_unstemmed Antigen-specific Immunosuppression in Visceral Leishmaniasis Is Cell Mediated
title_sort Antigen-specific Immunosuppression in Visceral Leishmaniasis Is Cell Mediated
author Carvalho, Edgar Marcelino de
author_facet Carvalho, Edgar Marcelino de
Bacellar, Maria Olívia Amado Ramos
Barral, Aldina Maria Prado
Badaró, Roberto José da Silva
Johnson Junior, Warren D
author_role author
author2 Bacellar, Maria Olívia Amado Ramos
Barral, Aldina Maria Prado
Badaró, Roberto José da Silva
Johnson Junior, Warren D
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, Edgar Marcelino de
Bacellar, Maria Olívia Amado Ramos
Barral, Aldina Maria Prado
Badaró, Roberto José da Silva
Johnson Junior, Warren D
dc.subject.other.pt_BR.fl_str_mv Leishmaniose visceral
Leishmania
Células
Imunossupressão
topic Leishmaniose visceral
Leishmania
Células
Imunossupressão
Leishmaniasis visceral
Leishmania
Cell
Immunosuppression
dc.subject.en.pt_BR.fl_str_mv Leishmaniasis visceral
Leishmania
Cell
Immunosuppression
description Barral, Aldina Maria Prado. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 1989
dc.date.issued.fl_str_mv 1989
dc.date.accessioned.fl_str_mv 2017-10-18T17:04:39Z
dc.date.available.fl_str_mv 2017-10-18T17:04:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARVALHO, E. M. et al. Antigen-specific Immunosuppression in Visceral Leishmaniasis Is Cell Mediated. Journal of Clinical Investigation, v. 83, n. 3, p. 860-864, 1989.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/22869
dc.identifier.issn.pt_BR.fl_str_mv 0021-9738
identifier_str_mv CARVALHO, E. M. et al. Antigen-specific Immunosuppression in Visceral Leishmaniasis Is Cell Mediated. Journal of Clinical Investigation, v. 83, n. 3, p. 860-864, 1989.
0021-9738
url https://www.arca.fiocruz.br/handle/icict/22869
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Clinical Investigation
publisher.none.fl_str_mv American Society for Clinical Investigation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/22869/1/license.txt
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https://www.arca.fiocruz.br/bitstream/icict/22869/3/Carvalho%20EM%20Antigenic-specific....pdf.txt
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