An isoniazid analogue promotes Mycobacterium tuberculosis-nanoparticle interactions and enhances bacterial killing by macrophages
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/27792 |
Resumo: | Universidade Federal de Santa Catarina. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Imunobiologia. Florianópolis, SC, Brasil. |
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Faria, Tatiany J. deRoman, MarianeSouza, Nicole M. deDe Vecchi, RodrigoAssis, João Vitor deSantos, Ana Lúcia Gomes dosBechtold, Ivan H.Winter, NathalieSoares, Maurilio JoséSilva, Luciano PaulinoAlmeida, Mauro Vieira deBáfica, André2018-08-02T14:09:04Z2018-08-02T14:09:04Z2012FARIA, Tatiany J. de et al. An Isoniazid Analogue Promotes Mycobacterium tuberculosis-Nanoparticle Interactions and Enhances Bacterial Killing by Macrophages. Antimicrobial Agents and Chemotherapy, v. 56, n. 5, p. 2259-2267, 2012.0066-4804https://www.arca.fiocruz.br/handle/icict/2779210.1128/AAC.05993-111098-6596porAmerican Society For MicrobiologyJVATuberculosisIsoniazidAnti-Bacterial AgentsDrug TherapyTratamiento FarmacológicoTuberculoseIsoniazidaAntibacterianosTratamento FarmacológicoAn isoniazid analogue promotes Mycobacterium tuberculosis-nanoparticle interactions and enhances bacterial killing by macrophagesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Santa Catarina. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Imunobiologia. Florianópolis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Imunobiologia. Florianópolis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Imunobiologia. Florianópolis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Imunobiologia. Florianópolis, SC, Brasil.Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.Universidade Federal de Santa Catarina. Departamento de Ciências Farmacêuticas. Florianópolis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Física. Florianópolis, SC, Brasil.INRA UR1282. Infectiologie Animale et Santé Publique. Nouzilly, France.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Celular. Curitiba, PR, Brasil.EMBRAPA Recursos Genéticos e Biotecnologia. Laboratório de Espectrometria de Massas, Brasília, Brasil.Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.Universidade Federal de Santa Catarina. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Imunobiologia. Florianópolis, SC, Brasil.Nanoenabled drug delivery systems against tuberculosis (TB) are thought to control pathogen replication by targeting antibiotics to infected tissues and phagocytes. However, whether nanoparticle (NP)-based carriers directly interact with Mycobacterium tuberculosis and how such drug delivery systems induce intracellular bacterial killing by macrophages is not defined. In the present study, we demonstrated that a highly hydrophobic citral-derived isoniazid analogue, termed JVA, significantly increases nanoencapsulation and inhibits M. tuberculosis growth by enhancing intracellular drug bioavailability. Importantly, confocal and atomic force microscopy analyses revealed that JVA-NPs associate with both intracellular M. tuberculosis and cell-free bacteria, indicating that NPs directly interact with the bacterium. Taken together, these data reveal a nanotechnology-based strategy that promotes antibiotic targeting into replicating extra- and intracellular mycobacteria, which could actively enhance chemotherapy during active TB.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/27792/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALAntim_Agent_Chemoth.pdfAntim_Agent_Chemoth.pdfapplication/pdf1740578https://www.arca.fiocruz.br/bitstream/icict/27792/2/Antim_Agent_Chemoth.pdf4916c56850e010be291c9281989fe7feMD52TEXTAntim_Agent_Chemoth.pdf.txtAntim_Agent_Chemoth.pdf.txtExtracted texttext/plain51107https://www.arca.fiocruz.br/bitstream/icict/27792/3/Antim_Agent_Chemoth.pdf.txtbb72c1176cd77ae817de6796ec08bcc8MD53icict/277922019-10-30 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| dc.title.pt_BR.fl_str_mv |
An isoniazid analogue promotes Mycobacterium tuberculosis-nanoparticle interactions and enhances bacterial killing by macrophages |
| title |
An isoniazid analogue promotes Mycobacterium tuberculosis-nanoparticle interactions and enhances bacterial killing by macrophages |
| spellingShingle |
An isoniazid analogue promotes Mycobacterium tuberculosis-nanoparticle interactions and enhances bacterial killing by macrophages Faria, Tatiany J. de JVA Tuberculosis Isoniazid Anti-Bacterial Agents Drug Therapy Tratamiento Farmacológico Tuberculose Isoniazida Antibacterianos Tratamento Farmacológico |
| title_short |
An isoniazid analogue promotes Mycobacterium tuberculosis-nanoparticle interactions and enhances bacterial killing by macrophages |
| title_full |
An isoniazid analogue promotes Mycobacterium tuberculosis-nanoparticle interactions and enhances bacterial killing by macrophages |
| title_fullStr |
An isoniazid analogue promotes Mycobacterium tuberculosis-nanoparticle interactions and enhances bacterial killing by macrophages |
| title_full_unstemmed |
An isoniazid analogue promotes Mycobacterium tuberculosis-nanoparticle interactions and enhances bacterial killing by macrophages |
| title_sort |
An isoniazid analogue promotes Mycobacterium tuberculosis-nanoparticle interactions and enhances bacterial killing by macrophages |
| author |
Faria, Tatiany J. de |
| author_facet |
Faria, Tatiany J. de Roman, Mariane Souza, Nicole M. de De Vecchi, Rodrigo Assis, João Vitor de Santos, Ana Lúcia Gomes dos Bechtold, Ivan H. Winter, Nathalie Soares, Maurilio José Silva, Luciano Paulino Almeida, Mauro Vieira de Báfica, André |
| author_role |
author |
| author2 |
Roman, Mariane Souza, Nicole M. de De Vecchi, Rodrigo Assis, João Vitor de Santos, Ana Lúcia Gomes dos Bechtold, Ivan H. Winter, Nathalie Soares, Maurilio José Silva, Luciano Paulino Almeida, Mauro Vieira de Báfica, André |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Faria, Tatiany J. de Roman, Mariane Souza, Nicole M. de De Vecchi, Rodrigo Assis, João Vitor de Santos, Ana Lúcia Gomes dos Bechtold, Ivan H. Winter, Nathalie Soares, Maurilio José Silva, Luciano Paulino Almeida, Mauro Vieira de Báfica, André |
| dc.subject.other.pt_BR.fl_str_mv |
JVA |
| topic |
JVA Tuberculosis Isoniazid Anti-Bacterial Agents Drug Therapy Tratamiento Farmacológico Tuberculose Isoniazida Antibacterianos Tratamento Farmacológico |
| dc.subject.en.pt_BR.fl_str_mv |
Tuberculosis Isoniazid Anti-Bacterial Agents Drug Therapy |
| dc.subject.es.pt_BR.fl_str_mv |
Tratamiento Farmacológico |
| dc.subject.decs.pt_BR.fl_str_mv |
Tuberculose Isoniazida Antibacterianos Tratamento Farmacológico |
| description |
Universidade Federal de Santa Catarina. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Imunobiologia. Florianópolis, SC, Brasil. |
| publishDate |
2012 |
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2012 |
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2018-08-02T14:09:04Z |
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2018-08-02T14:09:04Z |
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FARIA, Tatiany J. de et al. An Isoniazid Analogue Promotes Mycobacterium tuberculosis-Nanoparticle Interactions and Enhances Bacterial Killing by Macrophages. Antimicrobial Agents and Chemotherapy, v. 56, n. 5, p. 2259-2267, 2012. |
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https://www.arca.fiocruz.br/handle/icict/27792 |
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0066-4804 |
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10.1128/AAC.05993-11 |
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1098-6596 |
| identifier_str_mv |
FARIA, Tatiany J. de et al. An Isoniazid Analogue Promotes Mycobacterium tuberculosis-Nanoparticle Interactions and Enhances Bacterial Killing by Macrophages. Antimicrobial Agents and Chemotherapy, v. 56, n. 5, p. 2259-2267, 2012. 0066-4804 10.1128/AAC.05993-11 1098-6596 |
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American Society For Microbiology |
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American Society For Microbiology |
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