SUSCEPTIBILITY PROFILE TO TRICLOSAN OF CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS ISONIAZID RESISTANT

Detalhes bibliográficos
Autor(a) principal: Gautério, Daiane Porto
Data de Publicação: 2009
Outros Autores: Ribeiro, Marta Osório, Von Groll, Andrea, Silva, Márcia, Ramos, Daniela Fernandes, Rossetti, Maria Lucia, Scaini, Carlos James, Silva, Pedro Eduardo Almeida da
Tipo de documento: Artigo
Idioma: por
Título da fonte: Vittalle (Online)
DOI: 10.14295/vittalle.v20i1.952
Texto Completo: https://periodicos.furg.br/vittalle/article/view/952
Resumo: Triclosan is widely used in domestic and nosocomial places. One of the targets of triclosan is an enoyl-reductase present in M. tuberculosis and also is the main target to isoniazid (INH), which is an important drug for treatment of tuberculosis. The use of biocides that share similar targets with antimicrobials of human use can generate cross-resistance with these ones and it must be carefully evaluated. In this study was determined the minimal inhibitory concentration (MIC) of triclosan and INH to 46 clinical isolates of M. tuberculosis, previously identified as INH resistant by the proportion method. High levels of resistance to INH and susceptibility to triclosan were found in all strains.
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spelling SUSCEPTIBILITY PROFILE TO TRICLOSAN OF CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS ISONIAZID RESISTANTPERFIL DE SENSIBILIDADE AO TRICLOSAN DE ISOLADOS CLÍNICOS DE MYCOBACTERIUM TUBERCULOSIS RESISTENTES A ISONIAZIDAresistência aos antimicrobianosMycobacterium tuberculosistriclosanisoniazidaresistanceisoniazid.Triclosan is widely used in domestic and nosocomial places. One of the targets of triclosan is an enoyl-reductase present in M. tuberculosis and also is the main target to isoniazid (INH), which is an important drug for treatment of tuberculosis. The use of biocides that share similar targets with antimicrobials of human use can generate cross-resistance with these ones and it must be carefully evaluated. In this study was determined the minimal inhibitory concentration (MIC) of triclosan and INH to 46 clinical isolates of M. tuberculosis, previously identified as INH resistant by the proportion method. High levels of resistance to INH and susceptibility to triclosan were found in all strains.Triclosan é um biocida amplamente utilizado na comunidade e nos hospitais. Um dos alvos do triclosan é uma enoil-redutase que está presente no Mycobacterium tuberculosis, sendo também o principal alvo da isoniazida (INH), um importante fármaco utilizado para o tratamento da tuberculose. O uso de biocidas que compartilham alvos similares com antimicrobianos de uso humano podem gerar resistência cruzada com estes e devem ter o seu uso criteriosamente avaliado. Neste estudo, determinou-se a concentração mínima inibitória (CMI) do triclosan e INH para 46 isolados clínicos de M. tuberculosis previamente identificados como resistentes a INH, tendo sido observados altos níveis de resistência para INH e sensibilidade ao triclosan para todas as cepas.Universidade Federal do Rio Grande2009-08-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.furg.br/vittalle/article/view/95210.14295/vittalle.v20i1.952VITTALLE - Revista de Ciências da Saúde; v. 20 n. 1 (2008); 99-1062177-78531413-3563reponame:Vittalle (Online)instname:Universidade Federal do Rio Grande (FURG)instacron:FURGporhttps://periodicos.furg.br/vittalle/article/view/952/397Copyright (c) 2014 VITTALLE - Revista de Ciências da Saúdeinfo:eu-repo/semantics/openAccessGautério, Daiane PortoRibeiro, Marta OsórioVon Groll, AndreaSilva, MárciaRamos, Daniela FernandesRossetti, Maria LuciaScaini, Carlos JamesSilva, Pedro Eduardo Almeida da2013-12-11T17:34:17Zoai:periodicos.furg.br:article/952Revistahttps://periodicos.furg.br/vittallePUBhttps://periodicos.furg.br/vittalle/oaivittalle@furg.br2177-78531413-3563opendoar:2013-12-11T17:34:17Vittalle (Online) - Universidade Federal do Rio Grande (FURG)false
dc.title.none.fl_str_mv SUSCEPTIBILITY PROFILE TO TRICLOSAN OF CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS ISONIAZID RESISTANT
PERFIL DE SENSIBILIDADE AO TRICLOSAN DE ISOLADOS CLÍNICOS DE MYCOBACTERIUM TUBERCULOSIS RESISTENTES A ISONIAZIDA
title SUSCEPTIBILITY PROFILE TO TRICLOSAN OF CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS ISONIAZID RESISTANT
spellingShingle SUSCEPTIBILITY PROFILE TO TRICLOSAN OF CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS ISONIAZID RESISTANT
SUSCEPTIBILITY PROFILE TO TRICLOSAN OF CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS ISONIAZID RESISTANT
Gautério, Daiane Porto
resistência aos antimicrobianos
Mycobacterium tuberculosis
triclosan
isoniazida
resistance
isoniazid.
Gautério, Daiane Porto
resistência aos antimicrobianos
Mycobacterium tuberculosis
triclosan
isoniazida
resistance
isoniazid.
title_short SUSCEPTIBILITY PROFILE TO TRICLOSAN OF CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS ISONIAZID RESISTANT
title_full SUSCEPTIBILITY PROFILE TO TRICLOSAN OF CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS ISONIAZID RESISTANT
title_fullStr SUSCEPTIBILITY PROFILE TO TRICLOSAN OF CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS ISONIAZID RESISTANT
SUSCEPTIBILITY PROFILE TO TRICLOSAN OF CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS ISONIAZID RESISTANT
title_full_unstemmed SUSCEPTIBILITY PROFILE TO TRICLOSAN OF CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS ISONIAZID RESISTANT
SUSCEPTIBILITY PROFILE TO TRICLOSAN OF CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS ISONIAZID RESISTANT
title_sort SUSCEPTIBILITY PROFILE TO TRICLOSAN OF CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS ISONIAZID RESISTANT
author Gautério, Daiane Porto
author_facet Gautério, Daiane Porto
Gautério, Daiane Porto
Ribeiro, Marta Osório
Von Groll, Andrea
Silva, Márcia
Ramos, Daniela Fernandes
Rossetti, Maria Lucia
Scaini, Carlos James
Silva, Pedro Eduardo Almeida da
Ribeiro, Marta Osório
Von Groll, Andrea
Silva, Márcia
Ramos, Daniela Fernandes
Rossetti, Maria Lucia
Scaini, Carlos James
Silva, Pedro Eduardo Almeida da
author_role author
author2 Ribeiro, Marta Osório
Von Groll, Andrea
Silva, Márcia
Ramos, Daniela Fernandes
Rossetti, Maria Lucia
Scaini, Carlos James
Silva, Pedro Eduardo Almeida da
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gautério, Daiane Porto
Ribeiro, Marta Osório
Von Groll, Andrea
Silva, Márcia
Ramos, Daniela Fernandes
Rossetti, Maria Lucia
Scaini, Carlos James
Silva, Pedro Eduardo Almeida da
dc.subject.por.fl_str_mv resistência aos antimicrobianos
Mycobacterium tuberculosis
triclosan
isoniazida
resistance
isoniazid.
topic resistência aos antimicrobianos
Mycobacterium tuberculosis
triclosan
isoniazida
resistance
isoniazid.
description Triclosan is widely used in domestic and nosocomial places. One of the targets of triclosan is an enoyl-reductase present in M. tuberculosis and also is the main target to isoniazid (INH), which is an important drug for treatment of tuberculosis. The use of biocides that share similar targets with antimicrobials of human use can generate cross-resistance with these ones and it must be carefully evaluated. In this study was determined the minimal inhibitory concentration (MIC) of triclosan and INH to 46 clinical isolates of M. tuberculosis, previously identified as INH resistant by the proportion method. High levels of resistance to INH and susceptibility to triclosan were found in all strains.
publishDate 2009
dc.date.none.fl_str_mv 2009-08-07
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.furg.br/vittalle/article/view/952
10.14295/vittalle.v20i1.952
url https://periodicos.furg.br/vittalle/article/view/952
identifier_str_mv 10.14295/vittalle.v20i1.952
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.furg.br/vittalle/article/view/952/397
dc.rights.driver.fl_str_mv Copyright (c) 2014 VITTALLE - Revista de Ciências da Saúde
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2014 VITTALLE - Revista de Ciências da Saúde
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal do Rio Grande
publisher.none.fl_str_mv Universidade Federal do Rio Grande
dc.source.none.fl_str_mv VITTALLE - Revista de Ciências da Saúde; v. 20 n. 1 (2008); 99-106
2177-7853
1413-3563
reponame:Vittalle (Online)
instname:Universidade Federal do Rio Grande (FURG)
instacron:FURG
instname_str Universidade Federal do Rio Grande (FURG)
instacron_str FURG
institution FURG
reponame_str Vittalle (Online)
collection Vittalle (Online)
repository.name.fl_str_mv Vittalle (Online) - Universidade Federal do Rio Grande (FURG)
repository.mail.fl_str_mv vittalle@furg.br
_version_ 1822178794588340224
dc.identifier.doi.none.fl_str_mv 10.14295/vittalle.v20i1.952

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