Frequency of co-seropositivities for certain pathogens and their relationship with clinical and histopathological changes and parasite load in dogs infected with Leishmania infantum
| Autor(a) principal: | |
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| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/46792 |
Resumo: | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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Oliveira, Valéria da CostaMendes Junior, Artur Augusto VelhoFerreira, Luiz ClaudioCalvet, Tatiana Machado QuinatesSantos, Shanna Araujo dosFigueiredo, Fabiano BorgesCampos, Monique PaivaRodrigues, Francisco das Chagas de CarvalhoOliveira, Raquel de Vasconcellos Carvalhaes deLemos, Elba Regina Sampaio deRozental, TatianaSilva, Raphael Gomes daAmendoeira, Maria Regina ReisTeles-de-Freitas, RayaneBruno, Rafaela VieiraMorgado, Fernanda NazaréMiranda, Luciana de Freitas CamposMenezes, Rodrigo Caldas2021-04-20T20:09:55Z2021-04-20T20:09:55Z2021OLIVEIRA, Valéria da Costa et al. Frequency of co-seropositivities for certain pathogens and their relationship with clinical and histopathological changes and parasite load in dogs infected with Leishmania infantum. Plos One, v.16 n. 3, p. 1–20, 20211932-6203https://www.arca.fiocruz.br/handle/icict/4679210.1371/ journal.pone.0247560porNature ResearchLeishmanioseToxoplasma gondiiEhrlichia canisAnaplasmaLeishmania infantumCoinfectionDogsVirulenceCoinfecciónPerrosVirulenciaCo-infectionChiensLeishmania infantumCoinfecçãoCãesPatogenicidadeFrequency of co-seropositivities for certain pathogens and their relationship with clinical and histopathological changes and parasite load in dogs infected with Leishmania infantuminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.In canine leishmaniosis caused by the protozoan Leishmania infantum, little is known about how co-infections with or co-seropositivities for other pathogens can influence aggravation of this disease. Therefore, the objectives of this study were to evaluate the frequency of coinfections with or co-seropositivities for certain pathogens in dogs seropositive for L. infantum and their relationship with clinical signs, histological changes and L. infantum load. Sixty-six L. infantum-seropositive dogs were submitted to clinical examination, collection of blood and bone marrow, culling, and necropsy. Antibodies against Anaplasma spp., Borrelia burgdorferi sensu lato, Ehrlichia spp. and Toxoplasma gondii and Dirofilaria immitis antigens were investigated in serum. Samples from different tissues were submitted to histopathology and immunohistochemistry for the detection of Leishmania spp. and T. gondii. Quantitative real-time PCR was used to assess the L. infantum load in spleen samples. For detection of Coxiella burnetii, conventional PCR and nested PCR were performed using bone marrow samples. All 66 dogs tested positive for L. infantum by qPCR and/or culture. Fifty dogs (76%) were co-seropositive for at least one pathogen: T. gondii (59%), Ehrlichia spp., (41%), and Anaplasma spp. (18%). Clinical signs were observed in 15 (94%) dogs monoinfected with L. infantum and in 45 (90%) dogs co-seropositive for certain pathogens. The L. infantum load in spleen and skin did not differ significantly between monoinfected and co-seropositive dogs. The number of inflammatory cells was higher in the spleen, lung and mammary gland of co-seropositive dogs and in the mitral valve of monoinfected dogs. These results suggest that dogs infected with L. infantum and co-seropositive for certain pathogens are common in the region studied. However, co-seropositivities for certain pathogens did not aggravate clinical signs or L. infantum load, although they were associated with a more intense inflammatory reaction in some organs.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/46792/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALpone.0247560ok.pdfpone.0247560ok.pdfapplication/pdf2224064https://www.arca.fiocruz.br/bitstream/icict/46792/2/pone.0247560ok.pdfddf20bcc9f31d8cd9394a2face5d9043MD52TEXTpone.0247560ok.pdf.txtpone.0247560ok.pdf.txtExtracted texttext/plain78198https://www.arca.fiocruz.br/bitstream/icict/46792/3/pone.0247560ok.pdf.txtbdc1965ec48289710d81acbe897fcd3aMD53icict/467922021-04-21 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| dc.title.pt_BR.fl_str_mv |
Frequency of co-seropositivities for certain pathogens and their relationship with clinical and histopathological changes and parasite load in dogs infected with Leishmania infantum |
| title |
Frequency of co-seropositivities for certain pathogens and their relationship with clinical and histopathological changes and parasite load in dogs infected with Leishmania infantum |
| spellingShingle |
Frequency of co-seropositivities for certain pathogens and their relationship with clinical and histopathological changes and parasite load in dogs infected with Leishmania infantum Oliveira, Valéria da Costa Leishmaniose Toxoplasma gondii Ehrlichia canis Anaplasma Leishmania infantum Coinfection Dogs Virulence Coinfección Perros Virulencia Co-infection Chiens Leishmania infantum Coinfecção Cães Patogenicidade |
| title_short |
Frequency of co-seropositivities for certain pathogens and their relationship with clinical and histopathological changes and parasite load in dogs infected with Leishmania infantum |
| title_full |
Frequency of co-seropositivities for certain pathogens and their relationship with clinical and histopathological changes and parasite load in dogs infected with Leishmania infantum |
| title_fullStr |
Frequency of co-seropositivities for certain pathogens and their relationship with clinical and histopathological changes and parasite load in dogs infected with Leishmania infantum |
| title_full_unstemmed |
Frequency of co-seropositivities for certain pathogens and their relationship with clinical and histopathological changes and parasite load in dogs infected with Leishmania infantum |
| title_sort |
Frequency of co-seropositivities for certain pathogens and their relationship with clinical and histopathological changes and parasite load in dogs infected with Leishmania infantum |
| author |
Oliveira, Valéria da Costa |
| author_facet |
Oliveira, Valéria da Costa Mendes Junior, Artur Augusto Velho Ferreira, Luiz Claudio Calvet, Tatiana Machado Quinates Santos, Shanna Araujo dos Figueiredo, Fabiano Borges Campos, Monique Paiva Rodrigues, Francisco das Chagas de Carvalho Oliveira, Raquel de Vasconcellos Carvalhaes de Lemos, Elba Regina Sampaio de Rozental, Tatiana Silva, Raphael Gomes da Amendoeira, Maria Regina Reis Teles-de-Freitas, Rayane Bruno, Rafaela Vieira Morgado, Fernanda Nazaré Miranda, Luciana de Freitas Campos Menezes, Rodrigo Caldas |
| author_role |
author |
| author2 |
Mendes Junior, Artur Augusto Velho Ferreira, Luiz Claudio Calvet, Tatiana Machado Quinates Santos, Shanna Araujo dos Figueiredo, Fabiano Borges Campos, Monique Paiva Rodrigues, Francisco das Chagas de Carvalho Oliveira, Raquel de Vasconcellos Carvalhaes de Lemos, Elba Regina Sampaio de Rozental, Tatiana Silva, Raphael Gomes da Amendoeira, Maria Regina Reis Teles-de-Freitas, Rayane Bruno, Rafaela Vieira Morgado, Fernanda Nazaré Miranda, Luciana de Freitas Campos Menezes, Rodrigo Caldas |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Valéria da Costa Mendes Junior, Artur Augusto Velho Ferreira, Luiz Claudio Calvet, Tatiana Machado Quinates Santos, Shanna Araujo dos Figueiredo, Fabiano Borges Campos, Monique Paiva Rodrigues, Francisco das Chagas de Carvalho Oliveira, Raquel de Vasconcellos Carvalhaes de Lemos, Elba Regina Sampaio de Rozental, Tatiana Silva, Raphael Gomes da Amendoeira, Maria Regina Reis Teles-de-Freitas, Rayane Bruno, Rafaela Vieira Morgado, Fernanda Nazaré Miranda, Luciana de Freitas Campos Menezes, Rodrigo Caldas |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose Toxoplasma gondii Ehrlichia canis Anaplasma |
| topic |
Leishmaniose Toxoplasma gondii Ehrlichia canis Anaplasma Leishmania infantum Coinfection Dogs Virulence Coinfección Perros Virulencia Co-infection Chiens Leishmania infantum Coinfecção Cães Patogenicidade |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmania infantum Coinfection Dogs Virulence |
| dc.subject.es.pt_BR.fl_str_mv |
Coinfección Perros Virulencia |
| dc.subject.fr.pt_BR.fl_str_mv |
Co-infection Chiens |
| dc.subject.decs.pt_BR.fl_str_mv |
Leishmania infantum Coinfecção Cães Patogenicidade |
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Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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2021 |
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2021-04-20T20:09:55Z |
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2021-04-20T20:09:55Z |
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2021 |
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OLIVEIRA, Valéria da Costa et al. Frequency of co-seropositivities for certain pathogens and their relationship with clinical and histopathological changes and parasite load in dogs infected with Leishmania infantum. Plos One, v.16 n. 3, p. 1–20, 2021 |
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https://www.arca.fiocruz.br/handle/icict/46792 |
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1932-6203 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/ journal.pone.0247560 |
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OLIVEIRA, Valéria da Costa et al. Frequency of co-seropositivities for certain pathogens and their relationship with clinical and histopathological changes and parasite load in dogs infected with Leishmania infantum. Plos One, v.16 n. 3, p. 1–20, 2021 1932-6203 10.1371/ journal.pone.0247560 |
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Nature Research |
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Nature Research |
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