Four whole-istic aspects of schistosome granuloma biology: fractal arrangement, internal regulation, autopoietic component and closure
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2006 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/3747 http://dx.doi.org/10.1590/S0074-02762006000900034. |
Resumo: | Financial support: CNPq, Fiocruz |
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Lenzi, Henrique LeonelRomanha, Waldemiro de SouzaSantos, R. M. Zorzenon dosRosas, A.Mota, Ester MariaManso, Pedro Paulo de AbreuCaputo, Luzia F. G.Machado, Marcelo Pelajo2012-01-27T14:58:48Z2012-01-27T14:58:48Z2006LENZI, H. L. et al. Four whole-istic aspects of schistosome granuloma biology: fractal arrangement, internal regulation, autopoietic component and closure. Memórias do Instituto Oswaldo Cruz, v.101, supl.1, p. 219-231, 2006.0074-0276https://www.arca.fiocruz.br/handle/icict/3747http://dx.doi.org/10.1590/S0074-02762006000900034.Financial support: CNPq, FiocruzFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, BrasilUniversidade Federal de Pernambuco. Departamento de Física. Recife, PE, BrasilUniversidade Federal da Paraíba. Departamento de Física. João Pessoa, PB, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, BrasilThis paper centers on some whole-istic organizational and functional aspects of hepatic Schistosoma mansoni granuloma, which is an extremely complex system. First, it structurally develops a collagenic topology, originated bidirectionally from an inward and outward assembly of growth units. Inward growth appears to be originated from myofibroblasts derived from small portal vessel around intravascular entrapped eggs, while outward growth arises from hepatic stellate cells. The auto-assembly of the growth units defines the three-dimensional scaffold of the schistosome granulomas. The granuloma surface irregularity and its border presented fractal dimension equal to 1.58. Second, it is internally regulated by intricate networks of immuneneuroendocrine stimuli orchestrated by leptin and leptin receptors, substance P and Vasoactive intestinal peptide. Third, it can reach the population of ± 40,000 cells and presents an autopoietic component evidenced by internal proliferation (Ki-67+ Cells), and by expression of c-Kit+ Cells, leptin and leptin receptor (Ob-R), granulocyte-colony stimulating factor (G-CSF-R), and erythropoietin (Epo-R) receptors. Fourth, the granulomas cells are intimately connected by pan-cadherins, occludin and connexin-43, building a state of closing (granuloma closure). In conclusion, the granuloma is characterized by transitory stages in such a way that its organized structure emerges as a global property which is greater than the sum of actions of its individual cells and extracellular matrix components.engFundação Oswaldo Cruz. Instituto Oswaldo CruzFour whole-istic aspects of schistosome granuloma biology: fractal arrangement, internal regulation, autopoietic component and closureinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSchistosoma mansonigranulomaFractalLeptinOcludinConnexin-43Schistosoma mansoniGranulomaLeptinaPatologiaParasitologiaMetabolismoFatores de TempoModelos Animais de Doençasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALFour whole-istic aspects of schistosome granuloma biology.pdfFour whole-istic aspects of schistosome granuloma biology.pdfapplication/pdf27136048https://www.arca.fiocruz.br/bitstream/icict/3747/1/Four%20whole-istic%20aspects%20of%20schistosome%20granuloma%20biology.pdf68f5b106c7608be95432b04c157a4a4aMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/3747/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTFour whole-istic aspects of schistosome granuloma biology.pdf.txtFour whole-istic aspects of schistosome granuloma biology.pdf.txtExtracted texttext/plain43790https://www.arca.fiocruz.br/bitstream/icict/3747/5/Four%20whole-istic%20aspects%20of%20schistosome%20granuloma%20biology.pdf.txt5cdc6d07667c4533d6ef099d16450b5aMD55THUMBNAILFour whole-istic aspects of schistosome granuloma biology.pdf.jpgFour whole-istic aspects of schistosome granuloma biology.pdf.jpgGenerated Thumbnailimage/jpeg2368https://www.arca.fiocruz.br/bitstream/icict/3747/4/Four%20whole-istic%20aspects%20of%20schistosome%20granuloma%20biology.pdf.jpg4e3375a649282a29e654c8ade017e599MD54icict/37472018-04-06 09:02:50.628oai:www.arca.fiocruz.br:icict/3747Tk9OLUVYQ0xVU0lWRSBESVNUUklCVVRJT04gTElDRU5TRQoKQnkgc2lnbmluZyBhbmQgc3VibWl0dGluZyB0aGlzIGxpY2Vuc2UsIHlvdSAodGhlIGF1dGhvcihzKSBvciBjb3B5cmlnaHQKb3duZXIpIGdyYW50cyB0byBEU3BhY2UgVW5pdmVyc2l0eSAoRFNVKSB0aGUgbm9uLWV4Y2x1c2l2ZSByaWdodCB0byByZXByb2R1Y2UsCnRyYW5zbGF0ZSAoYXMgZGVmaW5lZCBiZWxvdyksIGFuZC9vciBkaXN0cmlidXRlIHlvdXIgc3VibWlzc2lvbiAoaW5jbHVkaW5nCnRoZSBhYnN0cmFjdCkgd29ybGR3aWRlIGluIHByaW50IGFuZCBlbGVjdHJvbmljIGZvcm1hdCBhbmQgaW4gYW55IG1lZGl1bSwKaW5jbHVkaW5nIGJ1dCBub3QgbGltaXRlZCB0byBhdWRpbyBvciB2aWRlby4KCllvdSBhZ3JlZSB0aGF0IERTVSBtYXksIHdpdGhvdXQgY2hhbmdpbmcgdGhlIGNvbnRlbnQsIHRyYW5zbGF0ZSB0aGUKc3VibWlzc2lvbiB0byBhbnkgbWVkaXVtIG9yIGZvcm1hdCBmb3IgdGhlIHB1cnBvc2Ugb2YgcHJlc2VydmF0aW9uLgoKWW91IGFsc28gYWdyZWUgdGhhdCBEU1UgbWF5IGtlZXAgbW9yZSB0aGFuIG9uZSBjb3B5IG9mIHRoaXMgc3VibWlzc2lvbiBmb3IKcHVycG9zZXMgb2Ygc2VjdXJpdHksIGJhY2stdXAgYW5kIHByZXNlcnZhdGlvbi4KCllvdSByZXByZXNlbnQgdGhhdCB0aGUgc3VibWlzc2lvbiBpcyB5b3VyIG9yaWdpbmFsIHdvcmssIGFuZCB0aGF0IHlvdSBoYXZlCnRoZSByaWdodCB0byBncmFudCB0aGUgcmlnaHRzIGNvbnRhaW5lZCBpbiB0aGlzIGxpY2Vuc2UuIFlvdSBhbHNvIHJlcHJlc2VudAp0aGF0IHlvdXIgc3VibWlzc2lvbiBkb2VzIG5vdCwgdG8gdGhlIGJlc3Qgb2YgeW91ciBrbm93bGVkZ2UsIGluZnJpbmdlIHVwb24KYW55b25lJ3MgY29weXJpZ2h0LgoKSWYgdGhlIHN1Ym1pc3Npb24gY29udGFpbnMgbWF0ZXJpYWwgZm9yIHdoaWNoIHlvdSBkbyBub3QgaG9sZCBjb3B5cmlnaHQsCnlvdSByZXByZXNlbnQgdGhhdCB5b3UgaGF2ZSBvYnRhaW5lZCB0aGUgdW5yZXN0cmljdGVkIHBlcm1pc3Npb24gb2YgdGhlCmNvcHlyaWdodCBvd25lciB0byBncmFudCBEU1UgdGhlIHJpZ2h0cyByZXF1aXJlZCBieSB0aGlzIGxpY2Vuc2UsIGFuZCB0aGF0CnN1Y2ggdGhpcmQtcGFydHkgb3duZWQgbWF0ZXJpYWwgaXMgY2xlYXJseSBpZGVudGlmaWVkIGFuZCBhY2tub3dsZWRnZWQKd2l0aGluIHRoZSB0ZXh0IG9yIGNvbnRlbnQgb2YgdGhlIHN1Ym1pc3Npb24uCgpJRiBUSEUgU1VCTUlTU0lPTiBJUyBCQVNFRCBVUE9OIFdPUksgVEhBVCBIQVMgQkVFTiBTUE9OU09SRUQgT1IgU1VQUE9SVEVECkJZIEFOIEFHRU5DWSBPUiBPUkdBTklaQVRJT04gT1RIRVIgVEhBTiBEU1UsIFlPVSBSRVBSRVNFTlQgVEhBVCBZT1UgSEFWRQpGVUxGSUxMRUQgQU5ZIFJJR0hUIE9GIFJFVklFVyBPUiBPVEhFUiBPQkxJR0FUSU9OUyBSRVFVSVJFRCBCWSBTVUNICkNPTlRSQUNUIE9SIEFHUkVFTUVOVC4KCkRTVSB3aWxsIGNsZWFybHkgaWRlbnRpZnkgeW91ciBuYW1lKHMpIGFzIHRoZSBhdXRob3Iocykgb3Igb3duZXIocykgb2YgdGhlCnN1Ym1pc3Npb24sIGFuZCB3aWxsIG5vdCBtYWtlIGFueSBhbHRlcmF0aW9uLCBvdGhlciB0aGFuIGFzIGFsbG93ZWQgYnkgdGhpcwpsaWNlbnNlLCB0byB5b3VyIHN1Ym1pc3Npb24uCg==Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T12:02:50Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Four whole-istic aspects of schistosome granuloma biology: fractal arrangement, internal regulation, autopoietic component and closure |
| title |
Four whole-istic aspects of schistosome granuloma biology: fractal arrangement, internal regulation, autopoietic component and closure |
| spellingShingle |
Four whole-istic aspects of schistosome granuloma biology: fractal arrangement, internal regulation, autopoietic component and closure Lenzi, Henrique Leonel Schistosoma mansoni granuloma Fractal Leptin Ocludin Connexin-43 Schistosoma mansoni Granuloma Leptina Patologia Parasitologia Metabolismo Fatores de Tempo Modelos Animais de Doenças |
| title_short |
Four whole-istic aspects of schistosome granuloma biology: fractal arrangement, internal regulation, autopoietic component and closure |
| title_full |
Four whole-istic aspects of schistosome granuloma biology: fractal arrangement, internal regulation, autopoietic component and closure |
| title_fullStr |
Four whole-istic aspects of schistosome granuloma biology: fractal arrangement, internal regulation, autopoietic component and closure |
| title_full_unstemmed |
Four whole-istic aspects of schistosome granuloma biology: fractal arrangement, internal regulation, autopoietic component and closure |
| title_sort |
Four whole-istic aspects of schistosome granuloma biology: fractal arrangement, internal regulation, autopoietic component and closure |
| author |
Lenzi, Henrique Leonel |
| author_facet |
Lenzi, Henrique Leonel Romanha, Waldemiro de Souza Santos, R. M. Zorzenon dos Rosas, A. Mota, Ester Maria Manso, Pedro Paulo de Abreu Caputo, Luzia F. G. Machado, Marcelo Pelajo |
| author_role |
author |
| author2 |
Romanha, Waldemiro de Souza Santos, R. M. Zorzenon dos Rosas, A. Mota, Ester Maria Manso, Pedro Paulo de Abreu Caputo, Luzia F. G. Machado, Marcelo Pelajo |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Lenzi, Henrique Leonel Romanha, Waldemiro de Souza Santos, R. M. Zorzenon dos Rosas, A. Mota, Ester Maria Manso, Pedro Paulo de Abreu Caputo, Luzia F. G. Machado, Marcelo Pelajo |
| dc.subject.en.pt_BR.fl_str_mv |
Schistosoma mansoni granuloma Fractal Leptin Ocludin Connexin-43 |
| topic |
Schistosoma mansoni granuloma Fractal Leptin Ocludin Connexin-43 Schistosoma mansoni Granuloma Leptina Patologia Parasitologia Metabolismo Fatores de Tempo Modelos Animais de Doenças |
| dc.subject.decs.pt_BR.fl_str_mv |
Schistosoma mansoni Granuloma Leptina Patologia Parasitologia Metabolismo Fatores de Tempo Modelos Animais de Doenças |
| description |
Financial support: CNPq, Fiocruz |
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2006 |
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2006 |
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2012-01-27T14:58:48Z |
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2012-01-27T14:58:48Z |
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LENZI, H. L. et al. Four whole-istic aspects of schistosome granuloma biology: fractal arrangement, internal regulation, autopoietic component and closure. Memórias do Instituto Oswaldo Cruz, v.101, supl.1, p. 219-231, 2006. |
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https://www.arca.fiocruz.br/handle/icict/3747 |
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0074-0276 |
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http://dx.doi.org/10.1590/S0074-02762006000900034. |
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LENZI, H. L. et al. Four whole-istic aspects of schistosome granuloma biology: fractal arrangement, internal regulation, autopoietic component and closure. Memórias do Instituto Oswaldo Cruz, v.101, supl.1, p. 219-231, 2006. 0074-0276 |
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