Collagen arrangement in hepatic granuloma in mice infected with Schistosoma mansoni: dependence on fiber radiation centers
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1999 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | http://dx.doi.org/10.1590/S0100-879X1999000500018 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/4072 http://dx.doi.org/10.1590/S0100-879X1999000500018 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil. |
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Lenzi, Henrique LeonelKimmel, E.Schechtman, H.Machado, Marcelo PelajoVale, Bruno SilvaPanasco, Monica de SouzaLenzi, Jane A.2012-05-15T16:07:34Z2012-05-15T16:07:34Z1999Lenzi, H.L. et al. Collagen arrangement in hepatic granuloma in mice infected with Schistosoma mansoni: dependence on fiber radiation centers. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v.32, n.5, p.639-643, May 1999.1414-431Xhttps://www.arca.fiocruz.br/handle/icict/4072http://dx.doi.org/10.1590/S0100-879X1999000500018engAssociação Brasileira de Divulgação CientíficaCollagen arrangement in hepatic granuloma in mice infected with Schistosoma mansoni: dependence on fiber radiation centersinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Israel Institute of Technology. Department of Agricultural Engineering, Technion. Haifa, IsraelFundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.The collagen structure of isolated and in situ liver granuloma from Swiss Webster mice infected with Schistosoma mansoni was sequentially and three-dimensionally analyzed during different times of infection (early acute, acute, transitional acute-chronic, and chronic phases) by laser scanning confocal microscopy and electron scanning variable vacuum microscopy. The initial granuloma structure is characterized by vascular collagen residues and by anchorage points (or fiber radiation centers), from where collagenous fibers are angularly shed and self-assembled. During the exudative-productive stage, the self-assembly of these fibers minimizes energy and mass through continuous tension and focal compression. The curvature or angles between collagen fibers probably depends on the fibroblastic or myofibroblastic organization of stress fibers. Gradually, the loose unstable lattice of the exudative-productive stage transforms into a highly packed and stable architecture as a result of progressive compactness. The three-dimensional architecture of granulomas provides increased tissue integrity, efficient distribution of soluble compounds and a haptotactic background to the cells.GranulomaSchistosoma mansoniCollagenExtracellular matrixConfocal microscopyGranulomaMicroscopia ConfocalSchistosoma mansoniColágenoMatriz Extracelularinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCollagen arrangement in hepatic.pdfCollagen arrangement in hepatic.pdfapplication/pdf462676https://www.arca.fiocruz.br/bitstream/icict/4072/1/Collagen%20arrangement%20in%20hepatic.pdf183b48afe9424d439d8e3b53c69205b5MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/4072/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTCollagen arrangement in hepatic.pdf.txtCollagen arrangement in hepatic.pdf.txtExtracted texttext/plain14833https://www.arca.fiocruz.br/bitstream/icict/4072/5/Collagen%20arrangement%20in%20hepatic.pdf.txt63e79abde14e1baf89f2b91521ae9338MD55THUMBNAILCollagen arrangement in hepatic.pdf.jpgCollagen arrangement in hepatic.pdf.jpgGenerated Thumbnailimage/jpeg2030https://www.arca.fiocruz.br/bitstream/icict/4072/4/Collagen%20arrangement%20in%20hepatic.pdf.jpg0e4d147ee1331be0dbd634a318a4ba94MD54icict/40722018-04-06 09:02:51.069oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T12:02:51Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Collagen arrangement in hepatic granuloma in mice infected with Schistosoma mansoni: dependence on fiber radiation centers |
| title |
Collagen arrangement in hepatic granuloma in mice infected with Schistosoma mansoni: dependence on fiber radiation centers |
| spellingShingle |
Collagen arrangement in hepatic granuloma in mice infected with Schistosoma mansoni: dependence on fiber radiation centers Lenzi, Henrique Leonel Granuloma Schistosoma mansoni Collagen Extracellular matrix Confocal microscopy Granuloma Microscopia Confocal Schistosoma mansoni Colágeno Matriz Extracelular |
| title_short |
Collagen arrangement in hepatic granuloma in mice infected with Schistosoma mansoni: dependence on fiber radiation centers |
| title_full |
Collagen arrangement in hepatic granuloma in mice infected with Schistosoma mansoni: dependence on fiber radiation centers |
| title_fullStr |
Collagen arrangement in hepatic granuloma in mice infected with Schistosoma mansoni: dependence on fiber radiation centers |
| title_full_unstemmed |
Collagen arrangement in hepatic granuloma in mice infected with Schistosoma mansoni: dependence on fiber radiation centers |
| title_sort |
Collagen arrangement in hepatic granuloma in mice infected with Schistosoma mansoni: dependence on fiber radiation centers |
| author |
Lenzi, Henrique Leonel |
| author_facet |
Lenzi, Henrique Leonel Kimmel, E. Schechtman, H. Machado, Marcelo Pelajo Vale, Bruno Silva Panasco, Monica de Souza Lenzi, Jane A. |
| author_role |
author |
| author2 |
Kimmel, E. Schechtman, H. Machado, Marcelo Pelajo Vale, Bruno Silva Panasco, Monica de Souza Lenzi, Jane A. |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Lenzi, Henrique Leonel Kimmel, E. Schechtman, H. Machado, Marcelo Pelajo Vale, Bruno Silva Panasco, Monica de Souza Lenzi, Jane A. |
| dc.subject.en.pt_BR.fl_str_mv |
Granuloma Schistosoma mansoni Collagen Extracellular matrix Confocal microscopy |
| topic |
Granuloma Schistosoma mansoni Collagen Extracellular matrix Confocal microscopy Granuloma Microscopia Confocal Schistosoma mansoni Colágeno Matriz Extracelular |
| dc.subject.decs.pt_BR.fl_str_mv |
Granuloma Microscopia Confocal Schistosoma mansoni Colágeno Matriz Extracelular |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil. |
| publishDate |
1999 |
| dc.date.issued.fl_str_mv |
1999 |
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2012-05-15T16:07:34Z |
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2012-05-15T16:07:34Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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Lenzi, H.L. et al. Collagen arrangement in hepatic granuloma in mice infected with Schistosoma mansoni: dependence on fiber radiation centers. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v.32, n.5, p.639-643, May 1999. |
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https://www.arca.fiocruz.br/handle/icict/4072 |
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1414-431X |
| dc.identifier.doi.none.fl_str_mv |
http://dx.doi.org/10.1590/S0100-879X1999000500018 |
| identifier_str_mv |
Lenzi, H.L. et al. Collagen arrangement in hepatic granuloma in mice infected with Schistosoma mansoni: dependence on fiber radiation centers. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v.32, n.5, p.639-643, May 1999. 1414-431X |
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https://www.arca.fiocruz.br/handle/icict/4072 http://dx.doi.org/10.1590/S0100-879X1999000500018 |
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Associação Brasileira de Divulgação Científica |
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