Factors associated with incident cardiovascular events and cardiac risk assessment in a cohort of hiv-infected participants in Rio de Janeiro

Detalhes bibliográficos
Autor(a) principal: Moreira, Rodrigo Carvalho
Data de Publicação: 2021
Outros Autores: Miranda, Mariana Alencar, Muller, Jessica, Cardoso, Sandra Wagner, Moreira, Ronaldo Ismerio, Nunes, Estevão, Griep, Rosane H., Fonseca, Maria Jesus, Veloso, Valdiléa G., Grinsztejn, Beatriz, Chor, Dóra, Pacheco, Antonio Guilherme
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46993
Resumo: Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
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spelling Moreira, Rodrigo CarvalhoMiranda, Mariana AlencarMuller, JessicaCardoso, Sandra WagnerMoreira, Ronaldo IsmerioNunes, EstevãoGriep, Rosane H.Fonseca, Maria JesusVeloso, Valdiléa G.Grinsztejn, BeatrizChor, DóraPacheco, Antonio Guilherme2021-05-01T13:14:30Z2021-05-01T13:14:30Z2021MOREIRA, Rodrigo Carvalho et al. Factors Associated with Incident Cardiovascular Events and Cardiac Risk Assessment in a Cohort of HIV-infected Participants in Rio de Janeiro. International Journal of Infectious Diseases and Therapy, v. 6, n. 1, p. 17-26, 2021.2578-9651https://www.arca.fiocruz.br/handle/icict/4699310.11648/j.ijidt.20210601.132578-966XengScience Publishing GroupSíndrome da Imunodeficiência AdquiridaDoenças CardiovascularesAvaliação do riscoAcquired Immunodeficiency SyndromeCardiovascular DiseaseRisk AssessmentFactors associated with incident cardiovascular events and cardiac risk assessment in a cohort of hiv-infected participants in Rio de Janeiroinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Medicina Interna. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Medicina Interna. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Computação Científica. Rio de Janeiro, RJ, BrasilBackground: Cardiovascular events (CVEs) have emerged as an important cause of morbimortality in people living with HIV/AIDS (PLHA). We aimed to investigate factors associated with incident CVE and compare the observed incidence with the predicted CVE risk by three different equations. Methods: Among the 649 active participants of the INI ELSA cohort, we analysed data of 644 individuals free of CVE at baseline examinations. We used Cox regression models to study factors associated with CVE and to assess the equation's performance we compared the observed incidence with the overall 5-year predicted risks. Results: Over a median follow-up of 6.26-years (interquartile range [IQR] 6.01-6.47), there were 18 CVE, four deaths. Overall, 57.92% were male, median age was 43.4 years (35.82-50.73), most were on cART (88.65%). Participants who had CVE were older, had poorer renal function, higher proportion of dyslipidemia and higher levels of systolic blood pressure and triglycerides. The observed CVE rate was 2.90% (1.60-4.90%) whereas their overall cardiovascular disease (CVD) risk differed depending on which score was used: 0.91 (0.42-20), 1.16 (0.38-2.78) and 1.68 (0.60-3.87), according to Framingham, ASCVD and DAD, respectively. In the multivariable Cox analysis black race, smoking 10+ packs years, dyslipidemia, current CD4 cell count x101 , cumulative viral load and time on NNRTI were independent predictors of CVE. Conclusion: Both traditional and HIV-related factors were associated with incident CVE. Risk scores were inconsistent in classifying patients who had CVE as high risk, indicating that validation studies are required to improve risk assessment of PLHA in Brazil.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/46993/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRodrigoMoreira_RosaneHGriep_etal_IOC_2021.pdfRodrigoMoreira_RosaneHGriep_etal_IOC_2021.pdfapplication/pdf760671https://www.arca.fiocruz.br/bitstream/icict/46993/2/RodrigoMoreira_RosaneHGriep_etal_IOC_2021.pdffcdf096ee81d454c1ef74ef61d55b2d3MD52TEXTRodrigoMoreira_RosaneHGriep_etal_IOC_2021.pdf.txtRodrigoMoreira_RosaneHGriep_etal_IOC_2021.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Factors associated with incident cardiovascular events and cardiac risk assessment in a cohort of hiv-infected participants in Rio de Janeiro
title Factors associated with incident cardiovascular events and cardiac risk assessment in a cohort of hiv-infected participants in Rio de Janeiro
spellingShingle Factors associated with incident cardiovascular events and cardiac risk assessment in a cohort of hiv-infected participants in Rio de Janeiro
Moreira, Rodrigo Carvalho
Síndrome da Imunodeficiência Adquirida
Doenças Cardiovasculares
Avaliação do risco
Acquired Immunodeficiency Syndrome
Cardiovascular Disease
Risk Assessment
title_short Factors associated with incident cardiovascular events and cardiac risk assessment in a cohort of hiv-infected participants in Rio de Janeiro
title_full Factors associated with incident cardiovascular events and cardiac risk assessment in a cohort of hiv-infected participants in Rio de Janeiro
title_fullStr Factors associated with incident cardiovascular events and cardiac risk assessment in a cohort of hiv-infected participants in Rio de Janeiro
title_full_unstemmed Factors associated with incident cardiovascular events and cardiac risk assessment in a cohort of hiv-infected participants in Rio de Janeiro
title_sort Factors associated with incident cardiovascular events and cardiac risk assessment in a cohort of hiv-infected participants in Rio de Janeiro
author Moreira, Rodrigo Carvalho
author_facet Moreira, Rodrigo Carvalho
Miranda, Mariana Alencar
Muller, Jessica
Cardoso, Sandra Wagner
Moreira, Ronaldo Ismerio
Nunes, Estevão
Griep, Rosane H.
Fonseca, Maria Jesus
Veloso, Valdiléa G.
Grinsztejn, Beatriz
Chor, Dóra
Pacheco, Antonio Guilherme
author_role author
author2 Miranda, Mariana Alencar
Muller, Jessica
Cardoso, Sandra Wagner
Moreira, Ronaldo Ismerio
Nunes, Estevão
Griep, Rosane H.
Fonseca, Maria Jesus
Veloso, Valdiléa G.
Grinsztejn, Beatriz
Chor, Dóra
Pacheco, Antonio Guilherme
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moreira, Rodrigo Carvalho
Miranda, Mariana Alencar
Muller, Jessica
Cardoso, Sandra Wagner
Moreira, Ronaldo Ismerio
Nunes, Estevão
Griep, Rosane H.
Fonseca, Maria Jesus
Veloso, Valdiléa G.
Grinsztejn, Beatriz
Chor, Dóra
Pacheco, Antonio Guilherme
dc.subject.other.pt_BR.fl_str_mv Síndrome da Imunodeficiência Adquirida
Doenças Cardiovasculares
Avaliação do risco
topic Síndrome da Imunodeficiência Adquirida
Doenças Cardiovasculares
Avaliação do risco
Acquired Immunodeficiency Syndrome
Cardiovascular Disease
Risk Assessment
dc.subject.en.pt_BR.fl_str_mv Acquired Immunodeficiency Syndrome
Cardiovascular Disease
Risk Assessment
description Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-05-01T13:14:30Z
dc.date.available.fl_str_mv 2021-05-01T13:14:30Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv MOREIRA, Rodrigo Carvalho et al. Factors Associated with Incident Cardiovascular Events and Cardiac Risk Assessment in a Cohort of HIV-infected Participants in Rio de Janeiro. International Journal of Infectious Diseases and Therapy, v. 6, n. 1, p. 17-26, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46993
dc.identifier.issn.pt_BR.fl_str_mv 2578-9651
dc.identifier.doi.none.fl_str_mv 10.11648/j.ijidt.20210601.13
dc.identifier.eissn.none.fl_str_mv 2578-966X
identifier_str_mv MOREIRA, Rodrigo Carvalho et al. Factors Associated with Incident Cardiovascular Events and Cardiac Risk Assessment in a Cohort of HIV-infected Participants in Rio de Janeiro. International Journal of Infectious Diseases and Therapy, v. 6, n. 1, p. 17-26, 2021.
2578-9651
10.11648/j.ijidt.20210601.13
2578-966X
url https://www.arca.fiocruz.br/handle/icict/46993
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Science Publishing Group
publisher.none.fl_str_mv Science Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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