Congenital and nursing effects on the evolution of Schistosoma mansoni infection in mice.

Detalhes bibliográficos
Autor(a) principal: Lenzi, Jane A.
Data de Publicação: 1987
Outros Autores: Sobral, A. C. L., Araripe, J. R., Grimaldi Filho, G., Lenzi, Henrique Leonel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/4055
http://dx.doi.org/10.1590/S0074-02761987000800049
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
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spelling Lenzi, Jane A.Sobral, A. C. L.Araripe, J. R.Grimaldi Filho, G.Lenzi, Henrique Leonel2012-05-10T14:50:43Z2012-05-10T14:50:43Z1987LENZI, J. A. et al. Congenital and nursing effects on the evolution of Schistosoma mansoni infection in mice. Memórias do Instituto Oswaldo Cruz, v.82, sup.4, p. 257-267, 1987.0074-0276https://www.arca.fiocruz.br/handle/icict/4055http://dx.doi.org/10.1590/S0074-02761987000800049engFundação Oswaldo Cruz. Instituto Oswaldo CruzCongenital and nursing effects on the evolution of Schistosoma mansoni infection in mice.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Modification of the immune response to schistosomal infection in children or offspring born to mother R infected with Schistosoma mansoni has been demonstrated in human and in experimental schistosomiasis. One of the hypothesis to explain this fact could be the transfer of circulating antigens and antibodies from mother to foetus through the placenta or from mother to child by milk. The results of this spontaneous transference are controversial in the literature. In an attempt to investigate these questions, we studied one hundred and twenty offspring (Swiss mice), sixty born to infected-mothers (group A) and sixty born to non-infected mothers (group B). These were percutaneously infected with 50 cercariae/mouse, and divided in six sub-groups (20 mice/sub-group), according to the following schedule: after birth (sub-groups A.I and B.I), 10 days old (sub-groups A.II and B.II) and 21 days old (sub-groups A.III and B.III). After the exposure period, the young mice returned to their own mothers for nursing. Six weeks later, the mice were killed. We obtained the following results: 1) There is transference of antibody to cercariae (CAP), adult worms (SWAP) and egg antigens (SEA) from the infected mothers to the offspring, probably through placenta and milk; 2) Offspring born to infected mothers exhibit much less coagulative hepatic necrosis and show a lower number of eggs in the small intestine and a less intense and predominant exsudative stage of the hepatic granulomas when compared with the exsudative-productive stage of the control groups. The findings suggest that congenital and nursing factors can interfere on the development of the schistosomiasis infection, causing an hyporesponse to the eggs.AntibodiesImmunologyHelminthMaternal-Fetal ExchangeSchistosomiasis mansoniPregnancy ComplicationsAntigensAnticorpos, imunologiaAntígenos de HelmintosTroca Materno-FetalEsquistossomose mansoniComplicações na Gravidezinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCongenital and nursing effects on the evolution of Schistosoma mansoni infection in mice.pdfCongenital and nursing effects on the evolution of Schistosoma mansoni infection in mice.pdfapplication/pdf516929https://www.arca.fiocruz.br/bitstream/icict/4055/1/Congenital%20and%20nursing%20effects%20on%20the%20evolution%20of%20Schistosoma%20mansoni%20infection%20in%20mice.pdf221c26b8410437733f6dc67ea15cc864MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/4055/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTCongenital and nursing effects on the evolution of Schistosoma mansoni infection in mice.pdf.txtCongenital and nursing effects on the evolution of Schistosoma mansoni infection in mice.pdf.txtExtracted texttext/plain11https://www.arca.fiocruz.br/bitstream/icict/4055/5/Congenital%20and%20nursing%20effects%20on%20the%20evolution%20of%20Schistosoma%20mansoni%20infection%20in%20mice.pdf.txtb308b7fe5c1c2bbdc0cb686d451b84aaMD55THUMBNAILCongenital and nursing effects on the evolution of Schistosoma mansoni infection in mice.pdf.jpgCongenital and nursing effects on the evolution of Schistosoma mansoni infection in mice.pdf.jpgGenerated Thumbnailimage/jpeg2518https://www.arca.fiocruz.br/bitstream/icict/4055/4/Congenital%20and%20nursing%20effects%20on%20the%20evolution%20of%20Schistosoma%20mansoni%20infection%20in%20mice.pdf.jpgabcb926f4029e6c92d6ad2f88fdea2f2MD54icict/40552018-04-06 08:58:02.379oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T11:58:02Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Congenital and nursing effects on the evolution of Schistosoma mansoni infection in mice.
title Congenital and nursing effects on the evolution of Schistosoma mansoni infection in mice.
spellingShingle Congenital and nursing effects on the evolution of Schistosoma mansoni infection in mice.
Lenzi, Jane A.
Antibodies
Immunology
Helminth
Maternal-Fetal Exchange
Schistosomiasis mansoni
Pregnancy Complications
Antigens
Anticorpos, imunologia
Antígenos de Helmintos
Troca Materno-Fetal
Esquistossomose mansoni
Complicações na Gravidez
title_short Congenital and nursing effects on the evolution of Schistosoma mansoni infection in mice.
title_full Congenital and nursing effects on the evolution of Schistosoma mansoni infection in mice.
title_fullStr Congenital and nursing effects on the evolution of Schistosoma mansoni infection in mice.
title_full_unstemmed Congenital and nursing effects on the evolution of Schistosoma mansoni infection in mice.
title_sort Congenital and nursing effects on the evolution of Schistosoma mansoni infection in mice.
author Lenzi, Jane A.
author_facet Lenzi, Jane A.
Sobral, A. C. L.
Araripe, J. R.
Grimaldi Filho, G.
Lenzi, Henrique Leonel
author_role author
author2 Sobral, A. C. L.
Araripe, J. R.
Grimaldi Filho, G.
Lenzi, Henrique Leonel
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Lenzi, Jane A.
Sobral, A. C. L.
Araripe, J. R.
Grimaldi Filho, G.
Lenzi, Henrique Leonel
dc.subject.en.pt_BR.fl_str_mv Antibodies
Immunology
Helminth
Maternal-Fetal Exchange
Schistosomiasis mansoni
Pregnancy Complications
Antigens
topic Antibodies
Immunology
Helminth
Maternal-Fetal Exchange
Schistosomiasis mansoni
Pregnancy Complications
Antigens
Anticorpos, imunologia
Antígenos de Helmintos
Troca Materno-Fetal
Esquistossomose mansoni
Complicações na Gravidez
dc.subject.decs.pt_BR.fl_str_mv Anticorpos, imunologia
Antígenos de Helmintos
Troca Materno-Fetal
Esquistossomose mansoni
Complicações na Gravidez
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
publishDate 1987
dc.date.issued.fl_str_mv 1987
dc.date.accessioned.fl_str_mv 2012-05-10T14:50:43Z
dc.date.available.fl_str_mv 2012-05-10T14:50:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv LENZI, J. A. et al. Congenital and nursing effects on the evolution of Schistosoma mansoni infection in mice. Memórias do Instituto Oswaldo Cruz, v.82, sup.4, p. 257-267, 1987.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/4055
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.1590/S0074-02761987000800049
identifier_str_mv LENZI, J. A. et al. Congenital and nursing effects on the evolution of Schistosoma mansoni infection in mice. Memórias do Instituto Oswaldo Cruz, v.82, sup.4, p. 257-267, 1987.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/4055
http://dx.doi.org/10.1590/S0074-02761987000800049
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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