CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population

Detalhes bibliográficos
Autor(a) principal: Coura, Renata dos
Data de Publicação: 2007
Outros Autores: Marques, Christiane de Fátima Silva, Koifman, Rosalina J., Koifman, Sergio, Cabello, Pedro Hernan, Hatagima, Ana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/29078
Resumo: Universidade Federal do Rio Grande do Sul. Programa de Pós-graduação em Genética e Biologia Molecular. Porto Alegre, RS, Brasil.
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spelling Coura, Renata dosMarques, Christiane de Fátima SilvaKoifman, Rosalina J.Koifman, SergioCabello, Pedro HernanHatagima, Ana2018-09-26T16:33:44Z2018-09-26T16:33:44Z2007COURA, Renata dos Santos; et al. CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population. Genetics and Molecular Biology, v.30,n.1, p.1-5, 2007.1415-4757https://www.arca.fiocruz.br/handle/icict/290781678-4685engSociedade Brasileira de GenéticaCYP2E1CYP1A1CitocromosBrasilcytochromes P450CYP1A1CYP2E1BrazilCYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio Grande do Sul. Programa de Pós-graduação em Genética e Biologia Molecular. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Genética. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro. RJ, BrasilFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro. RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Genética. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Genética. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.The enzymes encoded by the polymorphic genes CYP1A1 and CYP2E1 play an important role in the activation and inactivationofxenobiotics.Theseenzymeshavebeenassociatedwithxenobiotic-induceddiseases,suchascancer, therapeutic failure and adverse effects of drugs. The aim of the present study was to determine the allelic and genotypic frequencies of these polymorphisms in a large, ethnically mixed Brazilian population sample from Rio de Janeiro.PolymorphismsCYP1A1andCYP2E1weredeterminedin870unrelatedindividualsbyPCR-RFLPanalysis inperipheralbloodDNA.Theobservedallelicfrequencieswere0.90for CYP1A1*1A and0.95for CYP2E1*1A ,inthe total sample. The allelic frequency of CYP1A1*2C in “pardos” (0.13) and Brazilian whites (0.11) was higher than in Caucasians(0.05),whichmaybearesultoftheAmerindiangeneticcomponent,thatpresentsthehighestfrequency of this allele observed up to now. The genotype distributions for both polymorphisms were in Hardy-Weinberg equilibrium and were statistically different between males and females, and among ethnic groups.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/29078/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALcristiane_marques_etal_IOC_2007. pdf.pdfcristiane_marques_etal_IOC_2007. pdf.pdfapplication/pdf68927https://www.arca.fiocruz.br/bitstream/icict/29078/2/cristiane_marques_etal_IOC_2007.%20pdf.pdf76930c2b8beeea8285c3db1e9498a01fMD52TEXTcristiane_marques_etal_IOC_2007. pdf.pdf.txtcristiane_marques_etal_IOC_2007. pdf.pdf.txtExtracted texttext/plain22714https://www.arca.fiocruz.br/bitstream/icict/29078/3/cristiane_marques_etal_IOC_2007.%20pdf.pdf.txt53560fa02a97c3187f190eb7673ce5fdMD53icict/290782018-09-27 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dc.title.pt_BR.fl_str_mv CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
title CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
spellingShingle CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
Coura, Renata dos
CYP2E1
CYP1A1
Citocromos
Brasil
cytochromes P450
CYP1A1
CYP2E1
Brazil
title_short CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
title_full CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
title_fullStr CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
title_full_unstemmed CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
title_sort CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
author Coura, Renata dos
author_facet Coura, Renata dos
Marques, Christiane de Fátima Silva
Koifman, Rosalina J.
Koifman, Sergio
Cabello, Pedro Hernan
Hatagima, Ana
author_role author
author2 Marques, Christiane de Fátima Silva
Koifman, Rosalina J.
Koifman, Sergio
Cabello, Pedro Hernan
Hatagima, Ana
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Coura, Renata dos
Marques, Christiane de Fátima Silva
Koifman, Rosalina J.
Koifman, Sergio
Cabello, Pedro Hernan
Hatagima, Ana
dc.subject.other.pt_BR.fl_str_mv CYP2E1
CYP1A1
Citocromos
Brasil
topic CYP2E1
CYP1A1
Citocromos
Brasil
cytochromes P450
CYP1A1
CYP2E1
Brazil
dc.subject.en.pt_BR.fl_str_mv cytochromes P450
CYP1A1
CYP2E1
Brazil
description Universidade Federal do Rio Grande do Sul. Programa de Pós-graduação em Genética e Biologia Molecular. Porto Alegre, RS, Brasil.
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2018-09-26T16:33:44Z
dc.date.available.fl_str_mv 2018-09-26T16:33:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COURA, Renata dos Santos; et al. CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population. Genetics and Molecular Biology, v.30,n.1, p.1-5, 2007.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/29078
dc.identifier.issn.pt_BR.fl_str_mv 1415-4757
dc.identifier.eissn.none.fl_str_mv 1678-4685
identifier_str_mv COURA, Renata dos Santos; et al. CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population. Genetics and Molecular Biology, v.30,n.1, p.1-5, 2007.
1415-4757
1678-4685
url https://www.arca.fiocruz.br/handle/icict/29078
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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