CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
Autor(a) principal: | |
---|---|
Data de Publicação: | 2007 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Genetics and Molecular Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000100001 |
Resumo: | The enzymes encoded by the polymorphic genes CYP1A1 and CYP2E1 play an important role in the activation and inactivation of xenobiotics. These enzymes have been associated with xenobiotic-induced diseases, such as cancer, therapeutic failure and adverse effects of drugs. The aim of the present study was to determine the allelic and genotypic frequencies of these polymorphisms in a large, ethnically mixed Brazilian population sample from Rio de Janeiro. Polymorphisms CYP1A1 and CYP2E1 were determined in 870 unrelated individuals by PCR-RFLP analysis in peripheral blood DNA. The observed allelic frequencies were 0.90 for CYP1A1*1A and 0.95 for CYP2E1*1A, in the total sample. The allelic frequency of CYP1A1*2C in "pardos" (0.13) and Brazilian whites (0.11) was higher than in Caucasians (0.05), which may be a result of the Amerindian genetic component, that presents the highest frequency of this allele observed up to now. The genotype distributions for both polymorphisms were in Hardy-Weinberg equilibrium and were statistically different between males and females, and among ethnic groups. |
id |
SBG-1_e69f9841f1c39c948fa10680f65264a8 |
---|---|
oai_identifier_str |
oai:scielo:S1415-47572007000100001 |
network_acronym_str |
SBG-1 |
network_name_str |
Genetics and Molecular Biology |
repository_id_str |
|
spelling |
CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian populationcytochromes P450CYP1A1CYP2E1BrazilThe enzymes encoded by the polymorphic genes CYP1A1 and CYP2E1 play an important role in the activation and inactivation of xenobiotics. These enzymes have been associated with xenobiotic-induced diseases, such as cancer, therapeutic failure and adverse effects of drugs. The aim of the present study was to determine the allelic and genotypic frequencies of these polymorphisms in a large, ethnically mixed Brazilian population sample from Rio de Janeiro. Polymorphisms CYP1A1 and CYP2E1 were determined in 870 unrelated individuals by PCR-RFLP analysis in peripheral blood DNA. The observed allelic frequencies were 0.90 for CYP1A1*1A and 0.95 for CYP2E1*1A, in the total sample. The allelic frequency of CYP1A1*2C in "pardos" (0.13) and Brazilian whites (0.11) was higher than in Caucasians (0.05), which may be a result of the Amerindian genetic component, that presents the highest frequency of this allele observed up to now. The genotype distributions for both polymorphisms were in Hardy-Weinberg equilibrium and were statistically different between males and females, and among ethnic groups.Sociedade Brasileira de Genética2007-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000100001Genetics and Molecular Biology v.30 n.1 2007reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572007000100001info:eu-repo/semantics/openAccessCoura,Renata dos SantosMarques,Christiane de Fátima SilvaKoifman,Rosalina J.Koifman,SergioCabello,Pedro HernanHatagima,Anaeng2007-03-26T00:00:00Zoai:scielo:S1415-47572007000100001Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2007-03-26T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false |
dc.title.none.fl_str_mv |
CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population |
title |
CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population |
spellingShingle |
CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population Coura,Renata dos Santos cytochromes P450 CYP1A1 CYP2E1 Brazil |
title_short |
CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population |
title_full |
CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population |
title_fullStr |
CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population |
title_full_unstemmed |
CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population |
title_sort |
CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population |
author |
Coura,Renata dos Santos |
author_facet |
Coura,Renata dos Santos Marques,Christiane de Fátima Silva Koifman,Rosalina J. Koifman,Sergio Cabello,Pedro Hernan Hatagima,Ana |
author_role |
author |
author2 |
Marques,Christiane de Fátima Silva Koifman,Rosalina J. Koifman,Sergio Cabello,Pedro Hernan Hatagima,Ana |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Coura,Renata dos Santos Marques,Christiane de Fátima Silva Koifman,Rosalina J. Koifman,Sergio Cabello,Pedro Hernan Hatagima,Ana |
dc.subject.por.fl_str_mv |
cytochromes P450 CYP1A1 CYP2E1 Brazil |
topic |
cytochromes P450 CYP1A1 CYP2E1 Brazil |
description |
The enzymes encoded by the polymorphic genes CYP1A1 and CYP2E1 play an important role in the activation and inactivation of xenobiotics. These enzymes have been associated with xenobiotic-induced diseases, such as cancer, therapeutic failure and adverse effects of drugs. The aim of the present study was to determine the allelic and genotypic frequencies of these polymorphisms in a large, ethnically mixed Brazilian population sample from Rio de Janeiro. Polymorphisms CYP1A1 and CYP2E1 were determined in 870 unrelated individuals by PCR-RFLP analysis in peripheral blood DNA. The observed allelic frequencies were 0.90 for CYP1A1*1A and 0.95 for CYP2E1*1A, in the total sample. The allelic frequency of CYP1A1*2C in "pardos" (0.13) and Brazilian whites (0.11) was higher than in Caucasians (0.05), which may be a result of the Amerindian genetic component, that presents the highest frequency of this allele observed up to now. The genotype distributions for both polymorphisms were in Hardy-Weinberg equilibrium and were statistically different between males and females, and among ethnic groups. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000100001 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000100001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1415-47572007000100001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
Genetics and Molecular Biology v.30 n.1 2007 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
instname_str |
Sociedade Brasileira de Genética (SBG) |
instacron_str |
SBG |
institution |
SBG |
reponame_str |
Genetics and Molecular Biology |
collection |
Genetics and Molecular Biology |
repository.name.fl_str_mv |
Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG) |
repository.mail.fl_str_mv |
||editor@gmb.org.br |
_version_ |
1752122380281446400 |