CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population

Detalhes bibliográficos
Autor(a) principal: Coura,Renata dos Santos
Data de Publicação: 2007
Outros Autores: Marques,Christiane de Fátima Silva, Koifman,Rosalina J., Koifman,Sergio, Cabello,Pedro Hernan, Hatagima,Ana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000100001
Resumo: The enzymes encoded by the polymorphic genes CYP1A1 and CYP2E1 play an important role in the activation and inactivation of xenobiotics. These enzymes have been associated with xenobiotic-induced diseases, such as cancer, therapeutic failure and adverse effects of drugs. The aim of the present study was to determine the allelic and genotypic frequencies of these polymorphisms in a large, ethnically mixed Brazilian population sample from Rio de Janeiro. Polymorphisms CYP1A1 and CYP2E1 were determined in 870 unrelated individuals by PCR-RFLP analysis in peripheral blood DNA. The observed allelic frequencies were 0.90 for CYP1A1*1A and 0.95 for CYP2E1*1A, in the total sample. The allelic frequency of CYP1A1*2C in "pardos" (0.13) and Brazilian whites (0.11) was higher than in Caucasians (0.05), which may be a result of the Amerindian genetic component, that presents the highest frequency of this allele observed up to now. The genotype distributions for both polymorphisms were in Hardy-Weinberg equilibrium and were statistically different between males and females, and among ethnic groups.
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spelling CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian populationcytochromes P450CYP1A1CYP2E1BrazilThe enzymes encoded by the polymorphic genes CYP1A1 and CYP2E1 play an important role in the activation and inactivation of xenobiotics. These enzymes have been associated with xenobiotic-induced diseases, such as cancer, therapeutic failure and adverse effects of drugs. The aim of the present study was to determine the allelic and genotypic frequencies of these polymorphisms in a large, ethnically mixed Brazilian population sample from Rio de Janeiro. Polymorphisms CYP1A1 and CYP2E1 were determined in 870 unrelated individuals by PCR-RFLP analysis in peripheral blood DNA. The observed allelic frequencies were 0.90 for CYP1A1*1A and 0.95 for CYP2E1*1A, in the total sample. The allelic frequency of CYP1A1*2C in "pardos" (0.13) and Brazilian whites (0.11) was higher than in Caucasians (0.05), which may be a result of the Amerindian genetic component, that presents the highest frequency of this allele observed up to now. The genotype distributions for both polymorphisms were in Hardy-Weinberg equilibrium and were statistically different between males and females, and among ethnic groups.Sociedade Brasileira de Genética2007-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000100001Genetics and Molecular Biology v.30 n.1 2007reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572007000100001info:eu-repo/semantics/openAccessCoura,Renata dos SantosMarques,Christiane de Fátima SilvaKoifman,Rosalina J.Koifman,SergioCabello,Pedro HernanHatagima,Anaeng2007-03-26T00:00:00Zoai:scielo:S1415-47572007000100001Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2007-03-26T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
title CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
spellingShingle CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
Coura,Renata dos Santos
cytochromes P450
CYP1A1
CYP2E1
Brazil
title_short CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
title_full CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
title_fullStr CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
title_full_unstemmed CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
title_sort CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
author Coura,Renata dos Santos
author_facet Coura,Renata dos Santos
Marques,Christiane de Fátima Silva
Koifman,Rosalina J.
Koifman,Sergio
Cabello,Pedro Hernan
Hatagima,Ana
author_role author
author2 Marques,Christiane de Fátima Silva
Koifman,Rosalina J.
Koifman,Sergio
Cabello,Pedro Hernan
Hatagima,Ana
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Coura,Renata dos Santos
Marques,Christiane de Fátima Silva
Koifman,Rosalina J.
Koifman,Sergio
Cabello,Pedro Hernan
Hatagima,Ana
dc.subject.por.fl_str_mv cytochromes P450
CYP1A1
CYP2E1
Brazil
topic cytochromes P450
CYP1A1
CYP2E1
Brazil
description The enzymes encoded by the polymorphic genes CYP1A1 and CYP2E1 play an important role in the activation and inactivation of xenobiotics. These enzymes have been associated with xenobiotic-induced diseases, such as cancer, therapeutic failure and adverse effects of drugs. The aim of the present study was to determine the allelic and genotypic frequencies of these polymorphisms in a large, ethnically mixed Brazilian population sample from Rio de Janeiro. Polymorphisms CYP1A1 and CYP2E1 were determined in 870 unrelated individuals by PCR-RFLP analysis in peripheral blood DNA. The observed allelic frequencies were 0.90 for CYP1A1*1A and 0.95 for CYP2E1*1A, in the total sample. The allelic frequency of CYP1A1*2C in "pardos" (0.13) and Brazilian whites (0.11) was higher than in Caucasians (0.05), which may be a result of the Amerindian genetic component, that presents the highest frequency of this allele observed up to now. The genotype distributions for both polymorphisms were in Hardy-Weinberg equilibrium and were statistically different between males and females, and among ethnic groups.
publishDate 2007
dc.date.none.fl_str_mv 2007-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000100001
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000100001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47572007000100001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.30 n.1 2007
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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