Current status of stem cell therapy for liver diseases.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7480 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil |
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Souza, Bruno Solano de FreitasNogueira, Renata CamposOliveira, Sheilla Andrade deFreitas, Luiz Antonio Rodrigues deLyra, Luiz Guilherme CostaSantos, Ricardo Ribeiro dosLyra, André de CastroSoares, Milena Botelho Pereira2014-04-01T16:13:15Z2014-04-01T16:13:15Z2009SOUZA, B. S. et al. Current status of stem cell therapy for liver diseases. Cell Transplantation, v. 18, n. 12, p. 1261-1279, 2009.1555-3892https://www.arca.fiocruz.br/handle/icict/748010.3727/096368909X470522engCognizant Comm. Corp.Current status of stem cell therapy for liver diseases.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalha˜es, , Recife, Pernambuco, BrazilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, BrasilLiver failure is one of the main causes of death worldwide and is a growing health problem. Since the discovery of stem cell populations capable of differentiating into specialized cell types, including hepatocytes, the possibility of their utilization in the regeneration of the damaged liver has been a focus of intense investigation. A variety of cell types were tested both in vitro and in vivo, but the definition of a more suitable cell preparation for therapeutic use in each type of liver lesions is yet to be determined. Here we review the protocols described for differentiation of stem cells into hepatocytes, the results of cell therapy in animal models of liver diseases, as well as the available data of the clinical trials in patients with advanced chronic liver disease.Liver diseasesLiver regenerationStem cellsHepatocytesHepatopatias/terapiaFalência Hepática/terapiaTransplante de Células-TroncoDiferenciação CelularTerapia Baseada em Transplante de Células e TecidosHepatócitos/citologiaHumanosRegeneração HepáticaCélulas-Tronco/citologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSouza BS Current status of....pdfSouza BS Current status of....pdfapplication/pdf211586https://www.arca.fiocruz.br/bitstream/icict/7480/1/Souza%20BS%20Current%20status%20of....pdf8d5804b4dc69d201e1fb4ba685cd85a0MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81867https://www.arca.fiocruz.br/bitstream/icict/7480/2/license.txt89d048e714e969a1adcda05fdb1978beMD52TEXTSouza BS Current status of....pdf.txtSouza BS Current status of....pdf.txtExtracted texttext/plain96786https://www.arca.fiocruz.br/bitstream/icict/7480/5/Souza%20BS%20Current%20status%20of....pdf.txt5c38fe4b06fb9e794c594faf9b7f1363MD55THUMBNAILSouza BS Current status of....pdf.jpgSouza BS Current status of....pdf.jpgGenerated Thumbnailimage/jpeg1752https://www.arca.fiocruz.br/bitstream/icict/7480/4/Souza%20BS%20Current%20status%20of....pdf.jpg2ee7aac5b998e750f7c5d21cfe58d466MD54icict/74802023-03-15 14:33:10.945oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:10Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Current status of stem cell therapy for liver diseases. |
| title |
Current status of stem cell therapy for liver diseases. |
| spellingShingle |
Current status of stem cell therapy for liver diseases. Souza, Bruno Solano de Freitas Liver diseases Liver regeneration Stem cells Hepatocytes Hepatopatias/terapia Falência Hepática/terapia Transplante de Células-Tronco Diferenciação Celular Terapia Baseada em Transplante de Células e Tecidos Hepatócitos/citologia Humanos Regeneração Hepática Células-Tronco/citologia |
| title_short |
Current status of stem cell therapy for liver diseases. |
| title_full |
Current status of stem cell therapy for liver diseases. |
| title_fullStr |
Current status of stem cell therapy for liver diseases. |
| title_full_unstemmed |
Current status of stem cell therapy for liver diseases. |
| title_sort |
Current status of stem cell therapy for liver diseases. |
| author |
Souza, Bruno Solano de Freitas |
| author_facet |
Souza, Bruno Solano de Freitas Nogueira, Renata Campos Oliveira, Sheilla Andrade de Freitas, Luiz Antonio Rodrigues de Lyra, Luiz Guilherme Costa Santos, Ricardo Ribeiro dos Lyra, André de Castro Soares, Milena Botelho Pereira |
| author_role |
author |
| author2 |
Nogueira, Renata Campos Oliveira, Sheilla Andrade de Freitas, Luiz Antonio Rodrigues de Lyra, Luiz Guilherme Costa Santos, Ricardo Ribeiro dos Lyra, André de Castro Soares, Milena Botelho Pereira |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Souza, Bruno Solano de Freitas Nogueira, Renata Campos Oliveira, Sheilla Andrade de Freitas, Luiz Antonio Rodrigues de Lyra, Luiz Guilherme Costa Santos, Ricardo Ribeiro dos Lyra, André de Castro Soares, Milena Botelho Pereira |
| dc.subject.en.pt_BR.fl_str_mv |
Liver diseases Liver regeneration Stem cells Hepatocytes |
| topic |
Liver diseases Liver regeneration Stem cells Hepatocytes Hepatopatias/terapia Falência Hepática/terapia Transplante de Células-Tronco Diferenciação Celular Terapia Baseada em Transplante de Células e Tecidos Hepatócitos/citologia Humanos Regeneração Hepática Células-Tronco/citologia |
| dc.subject.decs.pt_BR.fl_str_mv |
Hepatopatias/terapia Falência Hepática/terapia Transplante de Células-Tronco Diferenciação Celular Terapia Baseada em Transplante de Células e Tecidos Hepatócitos/citologia Humanos Regeneração Hepática Células-Tronco/citologia |
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Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil |
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2009 |
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2009 |
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2014-04-01T16:13:15Z |
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2014-04-01T16:13:15Z |
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SOUZA, B. S. et al. Current status of stem cell therapy for liver diseases. Cell Transplantation, v. 18, n. 12, p. 1261-1279, 2009. |
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https://www.arca.fiocruz.br/handle/icict/7480 |
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1555-3892 |
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10.3727/096368909X470522 |
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SOUZA, B. S. et al. Current status of stem cell therapy for liver diseases. Cell Transplantation, v. 18, n. 12, p. 1261-1279, 2009. 1555-3892 10.3727/096368909X470522 |
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