CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite

Detalhes bibliográficos
Autor(a) principal: Neves, Juliana Costa Ferreira
Data de Publicação: 2022
Outros Autores: Ibiapina, Hiochelson Najibe Santos, Magalhães-Gama, Fábio, Sachett, Jacqueline Almeida Gonçalves, Silva, Iran Mendonça, Coelho, Kerolaine Fonseca, Alves, Eliane Campos, Tarragô, Andréa Monteiro, Ferreira, Luiz Carlos de Lima, Malheiro, Adriana, Monteiro, Wuelton Marcelo, Costa, Allyson Guimarães
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56529
Resumo: Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil.
id CRUZ_04cd80a494bbb05c5054816638f7c573
oai_identifier_str oai:www.arca.fiocruz.br:icict/56529
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Neves, Juliana Costa FerreiraIbiapina, Hiochelson Najibe SantosMagalhães-Gama, FábioSachett, Jacqueline Almeida GonçalvesSilva, Iran MendonçaCoelho, Kerolaine FonsecaAlves, Eliane CamposTarragô, Andréa MonteiroFerreira, Luiz Carlos de LimaMalheiro, AdrianaMonteiro, Wuelton MarceloCosta, Allyson Guimarães2023-01-19T17:12:02Z2023-01-19T17:12:02Z2022NEVES, Juliana Costa Ferreira et al. CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite. Mediators Inflamm., v. 2022, 8285084, 2022. doi: 10.1155/2022/8285084.0962-9351https://www.arca.fiocruz.br/handle/icict/56529engHindawi Pub. Corp.CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebiteinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePost-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil.Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil.Post-Graduate Program in Basic and Applied Immunology. Federal University of Amazonas. Manaus, AM, Brazil/Post-Graduate Program in Health Sciences. René Rachou Institute, Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Directorate of Teaching and Research. Hematology and Hemotherapy Foundation of Amazonas. Manaus, AM, Brazil.Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil/Amazonas Estate. Alfredo da Matta Foundation. Department of Education and Research. Manaus, AM, Brazil.Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil.Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil.Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil.Post-Graduate Program in Basic and Applied Immunology. Federal University of Amazonas. Manaus, AM, Brazil/ Directorate of Teaching and Research. Hematology and Hemotherapy Foundation of Amazonas. Manaus, AM, Brazil/Graduate Program in Sciences Applied to Hematology. Amazonas Estate University. Manaus, AM, Brazil.Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil.Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Post-Graduate Program in Basic and Applied Immunology. Federal University of Amazonas. Manaus, AM, Brazil/ Directorate of Teaching and Research. Hematology and Hemotherapy Foundation of Amazonas. Manaus, AM, Brazil/Graduate Program in Sciences Applied to Hematology. Amazonas Estate University. Manaus, AM, Brazil.Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil.Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil/Post-Graduate Program in Basic and Applied Immunology. Federal University of Amazonas. Manaus, AM, Brazil/Graduate Program in Health Sciences. René Rachou Institute, Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Directorate of Teaching and Research. Hematology and Hemotherapy Foundation of Amazonas. Manaus, AM, Brazil/Amazonas Estate. Alfredo da Matta Foundation. Department of Education and Research. Manaus, AM, Brazil/Post-Graduate Program in Sciences Applied to Hematology. Amazonas Estate University. Manaus, AM, Brazil/Nursing School of Manaus. Amazonas Federal University. Manaus, AM, Brazil.In the Brazilian Amazon, the snake Bothrops atrox is the primary cause of snakebites. B. atrox (BaV) venom can cause systemic pathophysiological changes such as acute kidney injury (AKI), which leads to the production of chemokines and cytokines in response to the envenomation. These soluble immunological molecules act by modulating the inflammatory response; however, the mechanisms associated with the development of AKI are still poorly understood. Here, we characterize the profile of these soluble immunological molecules as possible predictive biomarkers of the development of AKI. The study involved 34 patients who had been victims of snakebites by Bothrops sp. These were categorized into two groups according to the development of AKI (AKI(-)/AKI(+)), using healthy donors as the control (HD). Peripheral blood samples were collected at three-time points: before antivenom administration (T0) and at 24 and 48 hours after antivenom (T1 and T2, respectively). The soluble immunological molecules (CXCL-8, CCL-5, CXCL-9, CCL-2, CXCL-10, IL-6, TNF, IL-2, IL-10, IFN-γ, IL-4, and IL-17A) were quantified using cytometric bead array. Our results demonstrated an increase in CXCL-9, CXCL-10, IL-6, IL-2, IL-10, and IL-17A molecules in the groups of patients who suffered Bothrops snakebites (AKI(-) and AKI(+)) before antivenom administration, when compared to HD. In the AKI(+) group, levels of CXCL-8 and CCL-2 molecules were elevated on admission and progressively decreased during the clinical evolution of patients after antivenom administration. In addition, in the signature analysis, these were produced exclusively by the group AKI(+) at T0. Thus, these chemokines may be related to the initiation and extension of AKI after envenomation by Bothrops and present themselves as two potential biomarkers of AKI at T0.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56529/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCCL-2 and CXCL-8.pdfCCL-2 and CXCL-8.pdfapplication/pdf1370397https://www.arca.fiocruz.br/bitstream/icict/56529/2/CCL-2%20and%20CXCL-8.pdf8e411b47b5ff7379976d6c91350ee88eMD52icict/565292023-01-19 14:12:03.342oai:www.arca.fiocruz.br:icict/56529Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUwoKQW8gYWNlaXRhciBvcyBURVJNT1MgZSBDT05EScOHw5VFUyBkZXN0YSBDRVNTw4NPLCBvIEFVVE9SIGUvb3UgVElUVUxBUiBkZSBkaXJlaXRvcwphdXRvcmFpcyBzb2JyZSBhIE9CUkEgZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvOgoKKDEpIENFREUgZSBUUkFOU0ZFUkUsIHRvdGFsIGUgZ3JhdHVpdGFtZW50ZSwgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaLCBlbQpjYXLDoXRlciBwZXJtYW5lbnRlLCBpcnJldm9nw6F2ZWwgZSBOw4NPIEVYQ0xVU0lWTywgdG9kb3Mgb3MgZGlyZWl0b3MgcGF0cmltb25pYWlzIE7Dg08KQ09NRVJDSUFJUyBkZSB1dGlsaXphw6fDo28gZGEgT0JSQSBhcnTDrXN0aWNhIGUvb3UgY2llbnTDrWZpY2EgaW5kaWNhZGEgYWNpbWEsIGluY2x1c2l2ZSBvcyBkaXJlaXRvcwpkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBkdXJhbnRlIHRvZG8gbyBwcmF6byBkZSBkdXJhw6fDo28gZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBlbQpxdWFscXVlciBpZGlvbWEgZSBlbSB0b2RvcyBvcyBwYcOtc2VzOwoKKDIpIEFDRUlUQSBxdWUgYSBjZXNzw6NvIHRvdGFsIG7Do28gZXhjbHVzaXZhLCBwZXJtYW5lbnRlIGUgaXJyZXZvZ8OhdmVsIGRvcyBkaXJlaXRvcyBhdXRvcmFpcwpwYXRyaW1vbmlhaXMgbsOjbyBjb21lcmNpYWlzIGRlIHV0aWxpemHDp8OjbyBkZSBxdWUgdHJhdGEgZXN0ZSBkb2N1bWVudG8gaW5jbHVpLCBleGVtcGxpZmljYXRpdmFtZW50ZSwKb3MgZGlyZWl0b3MgZGUgZGlzcG9uaWJpbGl6YcOnw6NvIGUgY29tdW5pY2HDp8OjbyBww7pibGljYSBkYSBPQlJBLCBlbSBxdWFscXVlciBtZWlvIG91IHZlw61jdWxvLAppbmNsdXNpdmUgZW0gUmVwb3NpdMOzcmlvcyBEaWdpdGFpcywgYmVtIGNvbW8gb3MgZGlyZWl0b3MgZGUgcmVwcm9kdcOnw6NvLCBleGliacOnw6NvLCBleGVjdcOnw6NvLApkZWNsYW1hw6fDo28sIHJlY2l0YcOnw6NvLCBleHBvc2nDp8OjbywgYXJxdWl2YW1lbnRvLCBpbmNsdXPDo28gZW0gYmFuY28gZGUgZGFkb3MsIHByZXNlcnZhw6fDo28sIGRpZnVzw6NvLApkaXN0cmlidWnDp8OjbywgZGl2dWxnYcOnw6NvLCBlbXByw6lzdGltbywgdHJhZHXDp8OjbywgZHVibGFnZW0sIGxlZ2VuZGFnZW0sIGluY2x1c8OjbyBlbSBub3ZhcyBvYnJhcyBvdQpjb2xldMOibmVhcywgcmV1dGlsaXphw6fDo28sIGVkacOnw6NvLCBwcm9kdcOnw6NvIGRlIG1hdGVyaWFsIGRpZMOhdGljbyBlIGN1cnNvcyBvdSBxdWFscXVlciBmb3JtYSBkZQp1dGlsaXphw6fDo28gbsOjbyBjb21lcmNpYWw7CgooMykgUkVDT05IRUNFIHF1ZSBhIGNlc3PDo28gYXF1aSBlc3BlY2lmaWNhZGEgY29uY2VkZSDDoCBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPCkNSVVogbyBkaXJlaXRvIGRlIGF1dG9yaXphciBxdWFscXVlciBwZXNzb2Eg4oCTIGbDrXNpY2Egb3UganVyw61kaWNhLCBww7pibGljYSBvdSBwcml2YWRhLCBuYWNpb25hbCBvdQplc3RyYW5nZWlyYSDigJMgYSBhY2Vzc2FyIGUgdXRpbGl6YXIgYW1wbGFtZW50ZSBhIE9CUkEsIHNlbSBleGNsdXNpdmlkYWRlLCBwYXJhIHF1YWlzcXVlcgpmaW5hbGlkYWRlcyBuw6NvIGNvbWVyY2lhaXM7CgooNCkgREVDTEFSQSBxdWUgYSBvYnJhIMOpIGNyaWHDp8OjbyBvcmlnaW5hbCBlIHF1ZSDDqSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGFxdWkgY2VkaWRvcyBlIGF1dG9yaXphZG9zLApyZXNwb25zYWJpbGl6YW5kby1zZSBpbnRlZ3JhbG1lbnRlIHBlbG8gY29udGXDumRvIGUgb3V0cm9zIGVsZW1lbnRvcyBxdWUgZmF6ZW0gcGFydGUgZGEgT0JSQSwKaW5jbHVzaXZlIG9zIGRpcmVpdG9zIGRlIHZveiBlIGltYWdlbSB2aW5jdWxhZG9zIMOgIE9CUkEsIG9icmlnYW5kby1zZSBhIGluZGVuaXphciB0ZXJjZWlyb3MgcG9yCmRhbm9zLCBiZW0gY29tbyBpbmRlbml6YXIgZSByZXNzYXJjaXIgYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVogZGUKZXZlbnR1YWlzIGRlc3Blc2FzIHF1ZSB2aWVyZW0gYSBzdXBvcnRhciwgZW0gcmF6w6NvIGRlIHF1YWxxdWVyIG9mZW5zYSBhIGRpcmVpdG9zIGF1dG9yYWlzIG91CmRpcmVpdG9zIGRlIHZveiBvdSBpbWFnZW0sIHByaW5jaXBhbG1lbnRlIG5vIHF1ZSBkaXogcmVzcGVpdG8gYSBwbMOhZ2lvIGUgdmlvbGHDp8O1ZXMgZGUgZGlyZWl0b3M7CgooNSkgQUZJUk1BIHF1ZSBjb25oZWNlIGEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTwpPU1dBTERPIENSVVogZSBhcyBkaXJldHJpemVzIHBhcmEgbyBmdW5jaW9uYW1lbnRvIGRvIHJlcG9zaXTDs3JpbyBpbnN0aXR1Y2lvbmFsIEFSQ0EuCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIHJlc2VydmEKZXhjbHVzaXZhbWVudGUgYW8gQVVUT1Igb3MgZGlyZWl0b3MgbW9yYWlzIGUgb3MgdXNvcyBjb21lcmNpYWlzIHNvYnJlIGFzIG9icmFzIGRlIHN1YSBhdXRvcmlhCmUvb3UgdGl0dWxhcmlkYWRlLCBzZW5kbyBvcyB0ZXJjZWlyb3MgdXN1w6FyaW9zIHJlc3BvbnPDoXZlaXMgcGVsYSBhdHJpYnVpw6fDo28gZGUgYXV0b3JpYSBlIG1hbnV0ZW7Dp8OjbwpkYSBpbnRlZ3JpZGFkZSBkYSBPQlJBIGVtIHF1YWxxdWVyIHV0aWxpemHDp8Ojby4KCkEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVoKcmVzcGVpdGEgb3MgY29udHJhdG9zIGUgYWNvcmRvcyBwcmVleGlzdGVudGVzIGRvcyBBdXRvcmVzIGNvbSB0ZXJjZWlyb3MsIGNhYmVuZG8gYW9zIEF1dG9yZXMKaW5mb3JtYXIgw6AgSW5zdGl0dWnDp8OjbyBhcyBjb25kacOnw7VlcyBlIG91dHJhcyByZXN0cmnDp8O1ZXMgaW1wb3N0YXMgcG9yIGVzdGVzIGluc3RydW1lbnRvcy4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-01-19T17:12:03Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite
title CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite
spellingShingle CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite
Neves, Juliana Costa Ferreira
title_short CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite
title_full CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite
title_fullStr CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite
title_full_unstemmed CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite
title_sort CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite
author Neves, Juliana Costa Ferreira
author_facet Neves, Juliana Costa Ferreira
Ibiapina, Hiochelson Najibe Santos
Magalhães-Gama, Fábio
Sachett, Jacqueline Almeida Gonçalves
Silva, Iran Mendonça
Coelho, Kerolaine Fonseca
Alves, Eliane Campos
Tarragô, Andréa Monteiro
Ferreira, Luiz Carlos de Lima
Malheiro, Adriana
Monteiro, Wuelton Marcelo
Costa, Allyson Guimarães
author_role author
author2 Ibiapina, Hiochelson Najibe Santos
Magalhães-Gama, Fábio
Sachett, Jacqueline Almeida Gonçalves
Silva, Iran Mendonça
Coelho, Kerolaine Fonseca
Alves, Eliane Campos
Tarragô, Andréa Monteiro
Ferreira, Luiz Carlos de Lima
Malheiro, Adriana
Monteiro, Wuelton Marcelo
Costa, Allyson Guimarães
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Neves, Juliana Costa Ferreira
Ibiapina, Hiochelson Najibe Santos
Magalhães-Gama, Fábio
Sachett, Jacqueline Almeida Gonçalves
Silva, Iran Mendonça
Coelho, Kerolaine Fonseca
Alves, Eliane Campos
Tarragô, Andréa Monteiro
Ferreira, Luiz Carlos de Lima
Malheiro, Adriana
Monteiro, Wuelton Marcelo
Costa, Allyson Guimarães
description Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-01-19T17:12:02Z
dc.date.available.fl_str_mv 2023-01-19T17:12:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NEVES, Juliana Costa Ferreira et al. CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite. Mediators Inflamm., v. 2022, 8285084, 2022. doi: 10.1155/2022/8285084.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56529
dc.identifier.issn.en_US.fl_str_mv 0962-9351
identifier_str_mv NEVES, Juliana Costa Ferreira et al. CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite. Mediators Inflamm., v. 2022, 8285084, 2022. doi: 10.1155/2022/8285084.
0962-9351
url https://www.arca.fiocruz.br/handle/icict/56529
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Pub. Corp.
publisher.none.fl_str_mv Hindawi Pub. Corp.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56529/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/56529/2/CCL-2%20and%20CXCL-8.pdf
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
8e411b47b5ff7379976d6c91350ee88e
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798325034204266496

Registros relacionados