Antigen-specific assessment of the immunological status of various groups in a leprosy endemic region

Detalhes bibliográficos
Autor(a) principal: Fabri, Angélica da Conceição Oliveira Coelho
Data de Publicação: 2015
Outros Autores: Carvalho, Ana Paula Mendes, Araujo, Sergio, Goulart, Luiz Ricardo, Mattos, Ana Márcia Menezes de, Teixeira, Henrique Couto, Goulart, Isabela Maria Bernardes, Duthie, Malcolm S., Oliveira, Rodrigo Correa de, Lana, Francisco Carlos Félix
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12885
Resumo: Universidade Federal de Juiz de Fora. Faculdade de Enfermagem. Departamento de Enfermagem Básica. Juiz de Fora, MG, Brasil/Universidade Federal de Minas Gerais. Faculdade de Enfermagem. Belo Horizonte, MG
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spelling Fabri, Angélica da Conceição Oliveira CoelhoCarvalho, Ana Paula MendesAraujo, SergioGoulart, Luiz RicardoMattos, Ana Márcia Menezes deTeixeira, Henrique CoutoGoulart, Isabela Maria BernardesDuthie, Malcolm S.Oliveira, Rodrigo Correa deLana, Francisco Carlos Félix2016-02-26T18:33:58Z2016-02-26T18:33:58Z2015FABRI, Angélica da Conceição Oliveira Coelho et al. Antigen-specific assessment of the immunological status of various groups in a leprosy endemic region. BMC Infect Dis., vol. 15, p. 218, 20151471-2334https://www.arca.fiocruz.br/handle/icict/1288510.1186/s12879-015-0962-4engBioMed CentralAntigen-specific assessment of the immunological status of various groups in a leprosy endemic regioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Juiz de Fora. Faculdade de Enfermagem. Departamento de Enfermagem Básica. Juiz de Fora, MG, Brasil/Universidade Federal de Minas Gerais. Faculdade de Enfermagem. Belo Horizonte, MGUniversidade Federal de Minas Gerais. Faculdade de Enfermagem. Belo Horizonte, MGUniversidade Federal de Uberlandia. Hospital das Clínicas. Centro de Referencia Para Demartologia Sanitaria e Hansen. Uberlândia, MG, Brasil.Universidade Federal de Uberlandia. Instituto de Genetica e Bioquimica. Uberlândia, MG, Brasil/University of California-Davis. Department of Medical Microbiology and Immunology. Davis, CA, USA.Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Pos Graduaçao em Ciencias Biologicas. Imunologia e Doenças Infecciosas e Parasitarias. Juiz de Fora, MG, Brazil.Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, Brazil.Universidade Federal de Uberlandia. Hospital das Clínicas. Centro de Referencia Para Demartologia Sanitaria e Hansen. Uberlândia, MG, Brasil.Infectious Disease Research Institute. Seattle, WA, USA.Universidade Federal de Minas Gerais. Escola de Enfermagem. Pos Graduaçao em Enfermagem. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratorio de Imunologia Celular Molecular. Belo Horizonte, MG, Brasil/Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Laboratorio de Imunologia. Ouro Preto, MG, Brasil/Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Escola de Enfermagem. Pos Graduaçao em Enfermagem. Belo Horizonte, MG, Brasil/ Universidade Federal de Minas Gerais. Escola de Enfermagem. Departamento Enfermagem Materno Infantil e Saude Publica. Belo Horizonte, MG, BrasilBACKGROUND: Serological tests can be important tools to assist in the diagnosis of leprosy and can contribute to an earlier diagnosis. The aim of this study was to evaluate the antibody responses against phenolic glycolipid-1 (PGL-1), natural disaccharide linked to human serum albumin via an octyl (NDO-HSA), Leprosy IDRI Diagnostic-1 (LID-1) and natural disaccharide octyl--Leprosy IDRI Diagnostic-1 (NDO-LID) in leprosy patients, household contacts of patients and the general population. METHODS: Enzyme-linked immunosorbent assays were used to analyze the antigen-specific antibody responses of 94 leprosy cases, 104 household contacts of cases and 2.494 individuals from the general population. RESULTS: A positive correlation was observed for the antibody responses to all antigens studied. A higher proportion of seropositivity for all antigens, along with stronger magnitude of response, was observed in multibacillary (MB) leprosy patients and household contacts of MB leprosy patients compared with the levels observed in paucibacillary (PB) leprosy patients and household contacts of PB leprosy patients. A substantial and significant positive correlation was found between seropositivity and the bacterial index for the leprosy patients. Anti-PGL-1 tests were more frequently positive than anti-NDO-HSA tests among patients with all clinical forms of leprosy and among the group of household contacts. The LID-1 and NDO-LID antigens showed a greater capacity to identify household contacts and individuals from the general population infected with M. leprae. CONCLUSIONS: Tests that measure the antibody responses against LID-1, NDO-LID, NDO-HSA and PGL-1 were effective tools for the detection of patients with MB leprosy. Our data indicate that the anti-LID-1 and anti-NDO-LID responses were more effective than an anti-NDO-HSA response for the identification of individuals with subclinical infection.Hanseneprosyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12885/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAntigen-specific assessment of the immunological.pdfAntigen-specific assessment of the immunological.pdfapplication/pdf6289245https://www.arca.fiocruz.br/bitstream/icict/12885/2/Antigen-specific%20assessment%20of%20the%20immunological.pdfadf6408bb45ddf46959cf7f270b6c540MD52TEXTAntigen-specific assessment of the immunological.pdf.txtAntigen-specific assessment of the immunological.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Antigen-specific assessment of the immunological status of various groups in a leprosy endemic region
title Antigen-specific assessment of the immunological status of various groups in a leprosy endemic region
spellingShingle Antigen-specific assessment of the immunological status of various groups in a leprosy endemic region
Fabri, Angélica da Conceição Oliveira Coelho
Hansen
eprosy
title_short Antigen-specific assessment of the immunological status of various groups in a leprosy endemic region
title_full Antigen-specific assessment of the immunological status of various groups in a leprosy endemic region
title_fullStr Antigen-specific assessment of the immunological status of various groups in a leprosy endemic region
title_full_unstemmed Antigen-specific assessment of the immunological status of various groups in a leprosy endemic region
title_sort Antigen-specific assessment of the immunological status of various groups in a leprosy endemic region
author Fabri, Angélica da Conceição Oliveira Coelho
author_facet Fabri, Angélica da Conceição Oliveira Coelho
Carvalho, Ana Paula Mendes
Araujo, Sergio
Goulart, Luiz Ricardo
Mattos, Ana Márcia Menezes de
Teixeira, Henrique Couto
Goulart, Isabela Maria Bernardes
Duthie, Malcolm S.
Oliveira, Rodrigo Correa de
Lana, Francisco Carlos Félix
author_role author
author2 Carvalho, Ana Paula Mendes
Araujo, Sergio
Goulart, Luiz Ricardo
Mattos, Ana Márcia Menezes de
Teixeira, Henrique Couto
Goulart, Isabela Maria Bernardes
Duthie, Malcolm S.
Oliveira, Rodrigo Correa de
Lana, Francisco Carlos Félix
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fabri, Angélica da Conceição Oliveira Coelho
Carvalho, Ana Paula Mendes
Araujo, Sergio
Goulart, Luiz Ricardo
Mattos, Ana Márcia Menezes de
Teixeira, Henrique Couto
Goulart, Isabela Maria Bernardes
Duthie, Malcolm S.
Oliveira, Rodrigo Correa de
Lana, Francisco Carlos Félix
dc.subject.en.pt_BR.fl_str_mv Hansen
eprosy
topic Hansen
eprosy
description Universidade Federal de Juiz de Fora. Faculdade de Enfermagem. Departamento de Enfermagem Básica. Juiz de Fora, MG, Brasil/Universidade Federal de Minas Gerais. Faculdade de Enfermagem. Belo Horizonte, MG
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-02-26T18:33:58Z
dc.date.available.fl_str_mv 2016-02-26T18:33:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FABRI, Angélica da Conceição Oliveira Coelho et al. Antigen-specific assessment of the immunological status of various groups in a leprosy endemic region. BMC Infect Dis., vol. 15, p. 218, 2015
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12885
dc.identifier.issn.none.fl_str_mv 1471-2334
dc.identifier.doi.none.fl_str_mv 10.1186/s12879-015-0962-4
identifier_str_mv FABRI, Angélica da Conceição Oliveira Coelho et al. Antigen-specific assessment of the immunological status of various groups in a leprosy endemic region. BMC Infect Dis., vol. 15, p. 218, 2015
1471-2334
10.1186/s12879-015-0962-4
url https://www.arca.fiocruz.br/handle/icict/12885
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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