Immunomodulatory Role of Capsular Polysaccharides Constituents of Cryptococcus neoformans
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/40412 |
Resumo: | Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil. |
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Ricardo, Debora DecoteFreitas, Isabel Ferreira La Rocque deRocha, Juliana Dutra B.Nascimento, Danielle O.Nunes, Marise P.Morrot, AlexandreLima, Leonardo Freire dePreviato, Jose OsvaldoPreviato, Lucia MendonçaLima, Celio Geraldo Freire de2020-03-19T15:41:09Z2020-03-19T15:41:09Z2019RICARDO, Debora Decote et al. Immunomodulatory role of capsular Polysaccharides constituents of Criptococcus neoformans. Frontiers in Medicine, v. 6, Article 129, 8p, June 2019.2296-858Xhttps://www.arca.fiocruz.br/handle/icict/4041210.3389/fmed.2019.00129engFrontiers MediaCryptococcus neoformansGlucuronoxilomananoImunomodulaçãoEvasão imunológicaGalactoxilomananoCryptococcus neoformansGlucuronoxylomannan (GXM)Galactoxylomannan (GalXM)ImmunomodulationImmuno evasionImmunomodulatory Role of Capsular Polysaccharides Constituents of Cryptococcus neoformansinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Cryptococcosis is a systemic fungal infection caused by Cryptococcus neoformans. In immunocompetent patients, cryptococcal infection is often confined to the lungs. In immunocompromised individuals, C. neoformans may cause life-threatening illness, either from novel exposure or through reactivation of a previously acquired latent infection. For example, cryptococcal meningitis is a severe clinical disease that can manifest in people that are immunocompromised due to AIDS. The major constituents of the Cryptococcus polysaccharide capsule, glucuronoxylomannan (GXM), and galactoxylomannan (GalXM), also known as glucuronoxylomanogalactan (GXMGal), are considered the primary virulence factors of Cryptococcus. Despite the predominance of GXM in the polysaccharide capsule, GalXM has more robust immunomodulatory effects on host cellular immunity. This review summarizes current knowledge regarding host-Crytococcus neoformans interactions and the role of capsular polysaccharides in host immunomodulation. Future studies will likely facilitate a better understanding of the mechanisms involved in antigenic recognition and host immune response to C. neoformans and lead to the development of new therapeutic pathways for cryptococcal infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40412/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMariseNunes_AlexandreMorrot_etal_IOC_2019.pdfMariseNunes_AlexandreMorrot_etal_IOC_2019.pdfapplication/pdf281134https://www.arca.fiocruz.br/bitstream/icict/40412/2/MariseNunes_AlexandreMorrot_etal_IOC_2019.pdf889971e7c48db82f9ec1e4b6c01ce3c7MD52TEXTMariseNunes_AlexandreMorrot_etal_IOC_2019.pdf.txtMariseNunes_AlexandreMorrot_etal_IOC_2019.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Immunomodulatory Role of Capsular Polysaccharides Constituents of Cryptococcus neoformans |
| title |
Immunomodulatory Role of Capsular Polysaccharides Constituents of Cryptococcus neoformans |
| spellingShingle |
Immunomodulatory Role of Capsular Polysaccharides Constituents of Cryptococcus neoformans Ricardo, Debora Decote Cryptococcus neoformans Glucuronoxilomanano Imunomodulação Evasão imunológica Galactoxilomanano Cryptococcus neoformans Glucuronoxylomannan (GXM) Galactoxylomannan (GalXM) Immunomodulation Immuno evasion |
| title_short |
Immunomodulatory Role of Capsular Polysaccharides Constituents of Cryptococcus neoformans |
| title_full |
Immunomodulatory Role of Capsular Polysaccharides Constituents of Cryptococcus neoformans |
| title_fullStr |
Immunomodulatory Role of Capsular Polysaccharides Constituents of Cryptococcus neoformans |
| title_full_unstemmed |
Immunomodulatory Role of Capsular Polysaccharides Constituents of Cryptococcus neoformans |
| title_sort |
Immunomodulatory Role of Capsular Polysaccharides Constituents of Cryptococcus neoformans |
| author |
Ricardo, Debora Decote |
| author_facet |
Ricardo, Debora Decote Freitas, Isabel Ferreira La Rocque de Rocha, Juliana Dutra B. Nascimento, Danielle O. Nunes, Marise P. Morrot, Alexandre Lima, Leonardo Freire de Previato, Jose Osvaldo Previato, Lucia Mendonça Lima, Celio Geraldo Freire de |
| author_role |
author |
| author2 |
Freitas, Isabel Ferreira La Rocque de Rocha, Juliana Dutra B. Nascimento, Danielle O. Nunes, Marise P. Morrot, Alexandre Lima, Leonardo Freire de Previato, Jose Osvaldo Previato, Lucia Mendonça Lima, Celio Geraldo Freire de |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Ricardo, Debora Decote Freitas, Isabel Ferreira La Rocque de Rocha, Juliana Dutra B. Nascimento, Danielle O. Nunes, Marise P. Morrot, Alexandre Lima, Leonardo Freire de Previato, Jose Osvaldo Previato, Lucia Mendonça Lima, Celio Geraldo Freire de |
| dc.subject.other.pt_BR.fl_str_mv |
Cryptococcus neoformans Glucuronoxilomanano Imunomodulação Evasão imunológica Galactoxilomanano |
| topic |
Cryptococcus neoformans Glucuronoxilomanano Imunomodulação Evasão imunológica Galactoxilomanano Cryptococcus neoformans Glucuronoxylomannan (GXM) Galactoxylomannan (GalXM) Immunomodulation Immuno evasion |
| dc.subject.en.pt_BR.fl_str_mv |
Cryptococcus neoformans Glucuronoxylomannan (GXM) Galactoxylomannan (GalXM) Immunomodulation Immuno evasion |
| description |
Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil. |
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2019 |
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2019 |
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2020-03-19T15:41:09Z |
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2020-03-19T15:41:09Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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RICARDO, Debora Decote et al. Immunomodulatory role of capsular Polysaccharides constituents of Criptococcus neoformans. Frontiers in Medicine, v. 6, Article 129, 8p, June 2019. |
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https://www.arca.fiocruz.br/handle/icict/40412 |
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2296-858X |
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10.3389/fmed.2019.00129 |
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RICARDO, Debora Decote et al. Immunomodulatory role of capsular Polysaccharides constituents of Criptococcus neoformans. Frontiers in Medicine, v. 6, Article 129, 8p, June 2019. 2296-858X 10.3389/fmed.2019.00129 |
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