Association between Gc genotype and susceptibility to TB is dependent on vitamin D status
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/37454 |
Resumo: | 2020-11-28 |
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Martineau, Adrian R.Leandro, Ana Cristina C. S.Anderson, Suzanne T.Newton, Sandra M.Wilkinson, Katalin A.Nicol, Mark P.Pienaar, Sandra M.Skolimowska, Keira H.Rocha, Marcia A.Rolla, Valeria C.Levin, MichaelDavidson, Robert N.Bremner, Stephen A.Griffiths, Christopher J.Eley, Brian S.Bonecini-Almeida, M. GlóriaWilkinson, Robert J.2019-11-28T14:08:55Z2019-11-28T14:08:55Z2010MARTINEAU, Adrian R. et al. Association between Gc genotype and susceptibility to TB is dependent on vitamin D status. European Respiratory Journal, v. 35, n. 5, p. 1106-1112, May 2010.0903-1936https://www.arca.fiocruz.br/handle/icict/3745410.1183/09031936.000870091399-3003engEuropean Respiratory SocietyAssociation between Gc genotype and susceptibility to TB is dependent on vitamin D statusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-11-28Imperial College London. Wellcome Trust Centre for Research in Clinical Tropical Medicine. Division of Medicine. London, UK / Queen Mary’s. School of Medicine and Dentistry, Barts and The London. Centre for Health Sciences. London, UK / National Institute of Medical Research. Division of Mycobacterial Research. London, UK.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Imunologia e Imunogenética. Rio de Janeiro, RJ, Brasil.Imperial College London. Division of Medicine. Academic Department of Paediatrics. London, UK.Imperial College London. Division of Medicine. Academic Department of Paediatrics. London, UK.National Institute of Medical Research. Division of Mycobacterial Research. London, UK / University of Cape Town. Faculty of Health Sciences. Institute of Infectious Diseases and Molecular Medicine. Cape Town, South Africa.University of Cape Town. Faculty of Health Sciences. Institute of Infectious Diseases and Molecular Medicine. Cape Town, South Africa / University of Cape Town. Faculty of Health Sciences. Division of Medical Microbiology. Cape Town, South Africa / National Health Laboratory Services. Cape Town, South Africa.University of Cape Town. School of Child and Adolescent Health. Paediatric Infectious Diseases Unit. Cape Town, South Africa / Red Cross Children’s Hospital. Cape Town, South Africa.University of Cape Town. Faculty of Health Sciences. Institute of Infectious Diseases and Molecular Medicine. Cape Town, South Africa.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Imunologia e Imunogenética. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório Clínico em Tuberculose e Micobacterias. Rio de Janeiro, RJ, Brasil.Imperial College London. Division of Medicine. Academic Department of Paediatrics. London, UK.North West London Hospitals NHS Trust. Northwick Park Hospital. Tuberculosis Clinic. London, UK.Queen Mary’s. School of Medicine and Dentistry, Barts and The London. Centre for Health Sciences. London, UKQueen Mary’s. School of Medicine and Dentistry, Barts and The London. Centre for Health Sciences. London, UKUniversity of Cape Town. School of Child and Adolescent Health. Paediatric Infectious Diseases Unit. Cape Town, South Africa.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Imunologia e Imunogenética. Rio de Janeiro, RJ, Brasil.Imperial College London. Wellcome Trust Centre for Research in Clinical Tropical Medicine. Division of Medicine. London, UK / National Institute of Medical Research. Division of Mycobacterial Research. London, UK / University of Cape Town. Faculty of Health Sciences. Institute of Infectious Diseases and Molecular Medicine. Cape Town, South Africa.Gc variants of vitamin D binding protein differ in their affinity for vitamin D metabolites that modulate antimycobacterial immunity. We conducted studies to determine whether Gc genotype associates with susceptibility to tuberculosis. 123 adult tuberculosis patients and 140 controls of Gujarati Asian ethnic origin in the United Kingdom, 130 adult tuberculosis patients and 78 controls in Brazil, and 281 children with tuberculosis and 182 controls in South Africa were recruited to case-control studies. Gc genotypes were determined and their frequency was compared between cases vs. controls. Serum 25-hydroxyvitamin D (25[OH]D) concentrations were obtained retrospectively for 139 Gujarati Asians, and case-control analysis was stratified by vitamin D status. Interferon-γ release assays were also performed on 36 Gujarati tuberculosis contacts. The Gc2/2 genotype was strongly associated with susceptibility to active tuberculosis in Gujarati Asians, compared with Gc1/1 genotype (OR 2.81, 95% CI 1.19 to 6.66, P=0.009). This association was preserved if serum 25(OH)D was <20 nmol/l (P=0.01), but not if serum 25(OH)D was ≥20 nmol/l (P=0.36). Carriage of the Gc2 allele associated with increased PPD-stimulated Interferon-γ release in Gujarati Asian tuberculosis contacts (P = 0.02). No association between Gc genotype and susceptibility to tuberculosis was observed in other ethnic groups studied.Gc genotypeTuberculosisVitamin Dinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/37454/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Martineau_Adrian_etal_INI_2010.pdfve_Martineau_Adrian_etal_INI_2010.pdfapplication/pdf347846https://www.arca.fiocruz.br/bitstream/icict/37454/2/ve_Martineau_Adrian_etal_INI_2010.pdfb2dcea5b4d4f72a80274931b7313257eMD52TEXTve_Martineau_Adrian_etal_INI_2010.pdf.txtve_Martineau_Adrian_etal_INI_2010.pdf.txtExtracted texttext/plain40567https://www.arca.fiocruz.br/bitstream/icict/37454/3/ve_Martineau_Adrian_etal_INI_2010.pdf.txtfb2b98f92eec35ad940582ebae6d8f5aMD53icict/374542021-03-24 16:32:39.826oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:39Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Association between Gc genotype and susceptibility to TB is dependent on vitamin D status |
| title |
Association between Gc genotype and susceptibility to TB is dependent on vitamin D status |
| spellingShingle |
Association between Gc genotype and susceptibility to TB is dependent on vitamin D status Martineau, Adrian R. Gc genotype Tuberculosis Vitamin D |
| title_short |
Association between Gc genotype and susceptibility to TB is dependent on vitamin D status |
| title_full |
Association between Gc genotype and susceptibility to TB is dependent on vitamin D status |
| title_fullStr |
Association between Gc genotype and susceptibility to TB is dependent on vitamin D status |
| title_full_unstemmed |
Association between Gc genotype and susceptibility to TB is dependent on vitamin D status |
| title_sort |
Association between Gc genotype and susceptibility to TB is dependent on vitamin D status |
| author |
Martineau, Adrian R. |
| author_facet |
Martineau, Adrian R. Leandro, Ana Cristina C. S. Anderson, Suzanne T. Newton, Sandra M. Wilkinson, Katalin A. Nicol, Mark P. Pienaar, Sandra M. Skolimowska, Keira H. Rocha, Marcia A. Rolla, Valeria C. Levin, Michael Davidson, Robert N. Bremner, Stephen A. Griffiths, Christopher J. Eley, Brian S. Bonecini-Almeida, M. Glória Wilkinson, Robert J. |
| author_role |
author |
| author2 |
Leandro, Ana Cristina C. S. Anderson, Suzanne T. Newton, Sandra M. Wilkinson, Katalin A. Nicol, Mark P. Pienaar, Sandra M. Skolimowska, Keira H. Rocha, Marcia A. Rolla, Valeria C. Levin, Michael Davidson, Robert N. Bremner, Stephen A. Griffiths, Christopher J. Eley, Brian S. Bonecini-Almeida, M. Glória Wilkinson, Robert J. |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Martineau, Adrian R. Leandro, Ana Cristina C. S. Anderson, Suzanne T. Newton, Sandra M. Wilkinson, Katalin A. Nicol, Mark P. Pienaar, Sandra M. Skolimowska, Keira H. Rocha, Marcia A. Rolla, Valeria C. Levin, Michael Davidson, Robert N. Bremner, Stephen A. Griffiths, Christopher J. Eley, Brian S. Bonecini-Almeida, M. Glória Wilkinson, Robert J. |
| dc.subject.en.pt_BR.fl_str_mv |
Gc genotype Tuberculosis Vitamin D |
| topic |
Gc genotype Tuberculosis Vitamin D |
| description |
2020-11-28 |
| publishDate |
2010 |
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2010 |
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2019-11-28T14:08:55Z |
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2019-11-28T14:08:55Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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MARTINEAU, Adrian R. et al. Association between Gc genotype and susceptibility to TB is dependent on vitamin D status. European Respiratory Journal, v. 35, n. 5, p. 1106-1112, May 2010. |
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https://www.arca.fiocruz.br/handle/icict/37454 |
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0903-1936 |
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10.1183/09031936.00087009 |
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1399-3003 |
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MARTINEAU, Adrian R. et al. Association between Gc genotype and susceptibility to TB is dependent on vitamin D status. European Respiratory Journal, v. 35, n. 5, p. 1106-1112, May 2010. 0903-1936 10.1183/09031936.00087009 1399-3003 |
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eng |
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info:eu-repo/semantics/openAccess |
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European Respiratory Society |
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European Respiratory Society |
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