Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31375 |
Resumo: | The Brazilian National Council of Technological and Scientific Development, the Brazilian Coordination for the Improvement of Higher Education, the Bahia Foundation for Research Support, the National Institute of Neurological Disease and Stroke, the Manton Center for Orphan Disease Research, Boston Children’s Hospital Faculty Career Development Award and the David Rockefeller Center for Latin American Studies at Harvard University. |
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Kikuti, MarianaCardoso, Cristiane WanderleyPrates, Ana P. B.Paploski, Igor Adolfo DexheimerKitron, UrielReis, Mitermayer Galvão dosMochida, Ganeshwaran H.Ribeiro, Guilherme de Sousa2019-02-01T13:32:55Z2019-02-01T13:32:55Z2018KIKUTI, M. et al. Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016. Euro Surveillance, v. 23, n. 45, p. 1-10, 2018.1560-7917https://www.arca.fiocruz.br/handle/icict/3137510.2807/1560-7917.ES.2018.23.45.1700757The Brazilian National Council of Technological and Scientific Development, the Brazilian Coordination for the Improvement of Higher Education, the Bahia Foundation for Research Support, the National Institute of Neurological Disease and Stroke, the Manton Center for Orphan Disease Research, Boston Children’s Hospital Faculty Career Development Award and the David Rockefeller Center for Latin American Studies at Harvard University.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Secretaria Municipal de Saúde de Salvador. Salvador, BA, Brasil.Secretaria Municipal de Saúde de Salvador. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Emory University. Atlanta, United States.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Boston Children’s Hospital. Boston, United States / Massachusetts General Hospital. Boston, United States / Harvard Medical School. Boston, United States.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.North-eastern Brazil was the region most affected by the outbreak of congenital Zika syndrome that followed the 2015 Zika virus (ZIKV) epidemics, with thousands of suspected microcephaly cases reported to the health authorities, mostly between late 2015 and early 2016. Aim: To describe clinical and epidemiological aspects of the outbreak of congenital brain abnormalities (CBAs) and to evaluate the accuracy of different head circumference screening criteria in predicting CBAs. Method: Between April 2015 and July 2016, the Centers for Information and Epidemiologic Surveillance of Salvador, Brazil investigated the reported cases suspected of microcephaly and, based on intracranial imaging studies, confirmed or excluded a diagnosis of CBA. Sensitivity, specificity and positive and negative predictive values of different head circumference screening criteria in predicting CBAs were calculated. Results: Of the 365 investigated cases, 166 (45.5%) had confirmed CBAs. The most common findings were intracranial calcifications and ventriculomegaly in 143 (86.1%) and 111 (66.9%) of the 166 CBA cases, respectively. Prevalence of CBAs peaked in December 2015 (2.24 cases/100 live births). Cases of CBAs were significantly more likely to have been born preterm and to mothers who had clinical manifestations of arboviral infection during pregnancy. None of the head circumference screening criteria performed optimally in predicting CBAs. Conclusion: This study highlights the magnitude of neurological consequences of the ZIKV epidemic and the limitations of head circumference in accurately identifying children with CBA. Gestational symptoms compatible with ZIKV infection should be combined with imaging studies for efficient detection of suspect CBAs during ZIKV epidemics.engEuropean Centre for Disease Prevention and ControlZika virusMicrocefaliaAnomaliaInfecçãoGravidezEpidemiologiaPerímetro cefálicoNascidos vivosBrasilMalformações congenitasZika virusMicrocephalyAbnormalitiesInfectionPregnancyEpidemiologyCircumference screeningLive birthsBrazilCongenital malformationsCongenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31375/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALKIKUTI, M. Congenital brain abnormalitie...2018.pdfKIKUTI, M. 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| dc.title.pt_BR.fl_str_mv |
Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016 |
| title |
Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016 |
| spellingShingle |
Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016 Kikuti, Mariana Zika virus Microcefalia Anomalia Infecção Gravidez Epidemiologia Perímetro cefálico Nascidos vivos Brasil Malformações congenitas Zika virus Microcephaly Abnormalities Infection Pregnancy Epidemiology Circumference screening Live births Brazil Congenital malformations |
| title_short |
Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016 |
| title_full |
Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016 |
| title_fullStr |
Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016 |
| title_full_unstemmed |
Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016 |
| title_sort |
Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016 |
| author |
Kikuti, Mariana |
| author_facet |
Kikuti, Mariana Cardoso, Cristiane Wanderley Prates, Ana P. B. Paploski, Igor Adolfo Dexheimer Kitron, Uriel Reis, Mitermayer Galvão dos Mochida, Ganeshwaran H. Ribeiro, Guilherme de Sousa |
| author_role |
author |
| author2 |
Cardoso, Cristiane Wanderley Prates, Ana P. B. Paploski, Igor Adolfo Dexheimer Kitron, Uriel Reis, Mitermayer Galvão dos Mochida, Ganeshwaran H. Ribeiro, Guilherme de Sousa |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Kikuti, Mariana Cardoso, Cristiane Wanderley Prates, Ana P. B. Paploski, Igor Adolfo Dexheimer Kitron, Uriel Reis, Mitermayer Galvão dos Mochida, Ganeshwaran H. Ribeiro, Guilherme de Sousa |
| dc.subject.other.pt_BR.fl_str_mv |
Zika virus Microcefalia Anomalia Infecção Gravidez Epidemiologia Perímetro cefálico Nascidos vivos Brasil Malformações congenitas |
| topic |
Zika virus Microcefalia Anomalia Infecção Gravidez Epidemiologia Perímetro cefálico Nascidos vivos Brasil Malformações congenitas Zika virus Microcephaly Abnormalities Infection Pregnancy Epidemiology Circumference screening Live births Brazil Congenital malformations |
| dc.subject.en.pt_BR.fl_str_mv |
Zika virus Microcephaly Abnormalities Infection Pregnancy Epidemiology Circumference screening Live births Brazil Congenital malformations |
| description |
The Brazilian National Council of Technological and Scientific Development, the Brazilian Coordination for the Improvement of Higher Education, the Bahia Foundation for Research Support, the National Institute of Neurological Disease and Stroke, the Manton Center for Orphan Disease Research, Boston Children’s Hospital Faculty Career Development Award and the David Rockefeller Center for Latin American Studies at Harvard University. |
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2018 |
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2018 |
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2019-02-01T13:32:55Z |
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2019-02-01T13:32:55Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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KIKUTI, M. et al. Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016. Euro Surveillance, v. 23, n. 45, p. 1-10, 2018. |
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https://www.arca.fiocruz.br/handle/icict/31375 |
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1560-7917 |
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10.2807/1560-7917.ES.2018.23.45.1700757 |
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KIKUTI, M. et al. Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016. Euro Surveillance, v. 23, n. 45, p. 1-10, 2018. 1560-7917 10.2807/1560-7917.ES.2018.23.45.1700757 |
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European Centre for Disease Prevention and Control |
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European Centre for Disease Prevention and Control |
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