Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016

Bibliographic Details
Main Author: Kikuti, Mariana
Publication Date: 2018
Other Authors: Cardoso, Cristiane Wanderley, Prates, Ana P. B., Paploski, Igor Adolfo Dexheimer, Kitron, Uriel, Reis, Mitermayer Galvão dos, Mochida, Ganeshwaran H., Ribeiro, Guilherme de Sousa
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/31375
Summary: The Brazilian National Council of Technological and Scientific Development, the Brazilian Coordination for the Improvement of Higher Education, the Bahia Foundation for Research Support, the National Institute of Neurological Disease and Stroke, the Manton Center for Orphan Disease Research, Boston Children’s Hospital Faculty Career Development Award and the David Rockefeller Center for Latin American Studies at Harvard University.
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spelling Kikuti, MarianaCardoso, Cristiane WanderleyPrates, Ana P. B.Paploski, Igor Adolfo DexheimerKitron, UrielReis, Mitermayer Galvão dosMochida, Ganeshwaran H.Ribeiro, Guilherme de Sousa2019-02-01T13:32:55Z2019-02-01T13:32:55Z2018KIKUTI, M. et al. Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016. Euro Surveillance, v. 23, n. 45, p. 1-10, 2018.1560-7917https://www.arca.fiocruz.br/handle/icict/3137510.2807/1560-7917.ES.2018.23.45.1700757The Brazilian National Council of Technological and Scientific Development, the Brazilian Coordination for the Improvement of Higher Education, the Bahia Foundation for Research Support, the National Institute of Neurological Disease and Stroke, the Manton Center for Orphan Disease Research, Boston Children’s Hospital Faculty Career Development Award and the David Rockefeller Center for Latin American Studies at Harvard University.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Secretaria Municipal de Saúde de Salvador. Salvador, BA, Brasil.Secretaria Municipal de Saúde de Salvador. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Emory University. Atlanta, United States.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Boston Children’s Hospital. Boston, United States / Massachusetts General Hospital. Boston, United States / Harvard Medical School. Boston, United States.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.North-eastern Brazil was the region most affected by the outbreak of congenital Zika syndrome that followed the 2015 Zika virus (ZIKV) epidemics, with thousands of suspected microcephaly cases reported to the health authorities, mostly between late 2015 and early 2016. Aim: To describe clinical and epidemiological aspects of the outbreak of congenital brain abnormalities (CBAs) and to evaluate the accuracy of different head circumference screening criteria in predicting CBAs. Method: Between April 2015 and July 2016, the Centers for Information and Epidemiologic Surveillance of Salvador, Brazil investigated the reported cases suspected of microcephaly and, based on intracranial imaging studies, confirmed or excluded a diagnosis of CBA. Sensitivity, specificity and positive and negative predictive values of different head circumference screening criteria in predicting CBAs were calculated. Results: Of the 365 investigated cases, 166 (45.5%) had confirmed CBAs. The most common findings were intracranial calcifications and ventriculomegaly in 143 (86.1%) and 111 (66.9%) of the 166 CBA cases, respectively. Prevalence of CBAs peaked in December 2015 (2.24 cases/100 live births). Cases of CBAs were significantly more likely to have been born preterm and to mothers who had clinical manifestations of arboviral infection during pregnancy. None of the head circumference screening criteria performed optimally in predicting CBAs. Conclusion: This study highlights the magnitude of neurological consequences of the ZIKV epidemic and the limitations of head circumference in accurately identifying children with CBA. Gestational symptoms compatible with ZIKV infection should be combined with imaging studies for efficient detection of suspect CBAs during ZIKV epidemics.engEuropean Centre for Disease Prevention and ControlZika virusMicrocefaliaAnomaliaInfecçãoGravidezEpidemiologiaPerímetro cefálicoNascidos vivosBrasilMalformações congenitasZika virusMicrocephalyAbnormalitiesInfectionPregnancyEpidemiologyCircumference screeningLive birthsBrazilCongenital malformationsCongenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31375/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALKIKUTI, M. Congenital brain abnormalitie...2018.pdfKIKUTI, M. Congenital brain abnormalitie...2018.pdfapplication/pdf206258https://www.arca.fiocruz.br/bitstream/icict/31375/2/KIKUTI%2c%20M.%20Congenital%20brain%20abnormalitie...2018.pdf3991c4208908ad82ee462e12781815f7MD52TEXTKIKUTI, M. Congenital brain abnormalitie...2018.pdf.txtKIKUTI, M. 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dc.title.pt_BR.fl_str_mv Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016
title Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016
spellingShingle Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016
Kikuti, Mariana
Zika virus
Microcefalia
Anomalia
Infecção
Gravidez
Epidemiologia
Perímetro cefálico
Nascidos vivos
Brasil
Malformações congenitas
Zika virus
Microcephaly
Abnormalities
Infection
Pregnancy
Epidemiology
Circumference screening
Live births
Brazil
Congenital malformations
title_short Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016
title_full Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016
title_fullStr Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016
title_full_unstemmed Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016
title_sort Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016
author Kikuti, Mariana
author_facet Kikuti, Mariana
Cardoso, Cristiane Wanderley
Prates, Ana P. B.
Paploski, Igor Adolfo Dexheimer
Kitron, Uriel
Reis, Mitermayer Galvão dos
Mochida, Ganeshwaran H.
Ribeiro, Guilherme de Sousa
author_role author
author2 Cardoso, Cristiane Wanderley
Prates, Ana P. B.
Paploski, Igor Adolfo Dexheimer
Kitron, Uriel
Reis, Mitermayer Galvão dos
Mochida, Ganeshwaran H.
Ribeiro, Guilherme de Sousa
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kikuti, Mariana
Cardoso, Cristiane Wanderley
Prates, Ana P. B.
Paploski, Igor Adolfo Dexheimer
Kitron, Uriel
Reis, Mitermayer Galvão dos
Mochida, Ganeshwaran H.
Ribeiro, Guilherme de Sousa
dc.subject.other.pt_BR.fl_str_mv Zika virus
Microcefalia
Anomalia
Infecção
Gravidez
Epidemiologia
Perímetro cefálico
Nascidos vivos
Brasil
Malformações congenitas
topic Zika virus
Microcefalia
Anomalia
Infecção
Gravidez
Epidemiologia
Perímetro cefálico
Nascidos vivos
Brasil
Malformações congenitas
Zika virus
Microcephaly
Abnormalities
Infection
Pregnancy
Epidemiology
Circumference screening
Live births
Brazil
Congenital malformations
dc.subject.en.pt_BR.fl_str_mv Zika virus
Microcephaly
Abnormalities
Infection
Pregnancy
Epidemiology
Circumference screening
Live births
Brazil
Congenital malformations
description The Brazilian National Council of Technological and Scientific Development, the Brazilian Coordination for the Improvement of Higher Education, the Bahia Foundation for Research Support, the National Institute of Neurological Disease and Stroke, the Manton Center for Orphan Disease Research, Boston Children’s Hospital Faculty Career Development Award and the David Rockefeller Center for Latin American Studies at Harvard University.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-02-01T13:32:55Z
dc.date.available.fl_str_mv 2019-02-01T13:32:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv KIKUTI, M. et al. Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016. Euro Surveillance, v. 23, n. 45, p. 1-10, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31375
dc.identifier.issn.pt_BR.fl_str_mv 1560-7917
dc.identifier.doi.pt_BR.fl_str_mv 10.2807/1560-7917.ES.2018.23.45.1700757
identifier_str_mv KIKUTI, M. et al. Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016. Euro Surveillance, v. 23, n. 45, p. 1-10, 2018.
1560-7917
10.2807/1560-7917.ES.2018.23.45.1700757
url https://www.arca.fiocruz.br/handle/icict/31375
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv European Centre for Disease Prevention and Control
publisher.none.fl_str_mv European Centre for Disease Prevention and Control
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/31375/1/license.txt
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