Children born to mothers with rash during Zika Virus Epidemic in Brazil: first 18 months of life

Detalhes bibliográficos
Autor(a) principal: Vianna, Renata Artimos de Oliveira
Data de Publicação: 2019
Outros Autores: Lovero, Kathryn Lynn, Oliveira, Solange Artimos de, Fernandes, Alexandre Ribeiro, Santos, Teresa Cristina Sarmet dos, Lima, Luiz Cláudio Santos de Souza, Carvalho, Fabiana Rabe, Quintans, Maria Dolores Salgado, Bueno, Arnaldo Costa, Torbey, Ana Flávia Malheiros, Souza, Aurea Lucia Alves Azevedo Grippa de, Farias, Armanda de Oliveira Pache de, Camacho, Luiz Antonio Bastos, Riley, Lee Woodland, Cardoso, Claudete Aparecida Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/41499
Resumo: Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil.
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spelling Vianna, Renata Artimos de OliveiraLovero, Kathryn LynnOliveira, Solange Artimos deFernandes, Alexandre RibeiroSantos, Teresa Cristina Sarmet dosLima, Luiz Cláudio Santos de SouzaCarvalho, Fabiana RabeQuintans, Maria Dolores SalgadoBueno, Arnaldo CostaTorbey, Ana Flávia MalheirosSouza, Aurea Lucia Alves Azevedo Grippa deFarias, Armanda de Oliveira Pache deCamacho, Luiz Antonio BastosRiley, Lee WoodlandCardoso, Claudete Aparecida Araújo2020-06-03T14:23:15Z2020-06-03T14:23:15Z2019VIANNA, Renata A. de Oliveira et al. Children born to mothers with rash during Zika Virus Epidemic in Brazil: first 18 months of life. J. Tropical Pediatrics, v.65, n.6, p.592-602, 2019.0142-6338https://www.arca.fiocruz.br/handle/icict/4149910.1093/tropej/fmz0191465-3664engOxford University PressZika VirusMicrocefaliaCongenital Zika SyndromeRT-PCRZika VirusMicrocephalyZika VirusMicrocephalyChildren born to mothers with rash during Zika Virus Epidemic in Brazil: first 18 months of lifeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil.University of Columbia. Department of Psychiatry. New York, USA.Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro, RJ, Brasil.University of California. Division of Infectious Diseases and Vaccinology. Berkeley, USA.Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil.Objective: To better understand the clinical spectrum and course of congenital Zika syndrome (CZS) during the first 18 months of life of children whose mothers had rash during pregnancy. Methods: This longitudinal observational study evaluated the clinical progress from birth until 18 months of life of children of mothers who developed rash during or up to 3 months before gestation. Maternal rash occurred from November 2015 to May 2017. The study subjects were divided into three groups: children whose mothers tested positive by RT-qPCR for Zika virus (ZIKV) (Group 1), children whose mothers tested negative by RT-qPCR for ZIKV (Group 2), and children whose mothers did not undergo any testing for ZIKV (Group 3) but tested negative for other congenital infections. Results: Between April 2016 and July 2018, we studied 108 children: 43 in Group 1, 26 in Group 2 and 39 in Group 3. The majority of children were admitted into the study within 6 months of life. CZS was diagnosed in 26 children, equally distributed in Groups 1 and 3. Of 18 children with microcephaly, 6 were in Group 1 (1 postnatal) and 12 were in Group 3 (5 postnatal). Maternal rash frequency was 10 times higher during the first trimester than in the other trimesters (OR: 10.35; CI 95%: 3.52-30.41). CZS was diagnosed during the follow-up period in 14 (54%) cases. Developmental delays and motor abnormalities occurred in all children and persisted up to 18 months. Epilepsy occurred in 18 (69%) of the cases. Conclusions: Infants born of mothers exposed to ZIKV during pregnancy showed progression of developmental, motor and neurologic abnormalities even if they were born asymptomatic. Continued postnatal monitoring of such newborns is necessary to preclude disability-associated complications.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/41499/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALChildrenBornZikaEpidemicBrazil.pdfChildrenBornZikaEpidemicBrazil.pdfapplication/pdf161442https://www.arca.fiocruz.br/bitstream/icict/41499/2/ChildrenBornZikaEpidemicBrazil.pdfa439b58ddc8a16605a84a346dfae99ebMD52TEXTChildrenBornZikaEpidemicBrazil.pdf.txtChildrenBornZikaEpidemicBrazil.pdf.txtExtracted texttext/plain38313https://www.arca.fiocruz.br/bitstream/icict/41499/3/ChildrenBornZikaEpidemicBrazil.pdf.txt841ff0997bf726786b88c6bb36a7741cMD53icict/414992020-06-04 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dc.title.pt_BR.fl_str_mv Children born to mothers with rash during Zika Virus Epidemic in Brazil: first 18 months of life
title Children born to mothers with rash during Zika Virus Epidemic in Brazil: first 18 months of life
spellingShingle Children born to mothers with rash during Zika Virus Epidemic in Brazil: first 18 months of life
Vianna, Renata Artimos de Oliveira
Zika Virus
Microcefalia
Congenital Zika Syndrome
RT-PCR
Zika Virus
Microcephaly
Zika Virus
Microcephaly
title_short Children born to mothers with rash during Zika Virus Epidemic in Brazil: first 18 months of life
title_full Children born to mothers with rash during Zika Virus Epidemic in Brazil: first 18 months of life
title_fullStr Children born to mothers with rash during Zika Virus Epidemic in Brazil: first 18 months of life
title_full_unstemmed Children born to mothers with rash during Zika Virus Epidemic in Brazil: first 18 months of life
title_sort Children born to mothers with rash during Zika Virus Epidemic in Brazil: first 18 months of life
author Vianna, Renata Artimos de Oliveira
author_facet Vianna, Renata Artimos de Oliveira
Lovero, Kathryn Lynn
Oliveira, Solange Artimos de
Fernandes, Alexandre Ribeiro
Santos, Teresa Cristina Sarmet dos
Lima, Luiz Cláudio Santos de Souza
Carvalho, Fabiana Rabe
Quintans, Maria Dolores Salgado
Bueno, Arnaldo Costa
Torbey, Ana Flávia Malheiros
Souza, Aurea Lucia Alves Azevedo Grippa de
Farias, Armanda de Oliveira Pache de
Camacho, Luiz Antonio Bastos
Riley, Lee Woodland
Cardoso, Claudete Aparecida Araújo
author_role author
author2 Lovero, Kathryn Lynn
Oliveira, Solange Artimos de
Fernandes, Alexandre Ribeiro
Santos, Teresa Cristina Sarmet dos
Lima, Luiz Cláudio Santos de Souza
Carvalho, Fabiana Rabe
Quintans, Maria Dolores Salgado
Bueno, Arnaldo Costa
Torbey, Ana Flávia Malheiros
Souza, Aurea Lucia Alves Azevedo Grippa de
Farias, Armanda de Oliveira Pache de
Camacho, Luiz Antonio Bastos
Riley, Lee Woodland
Cardoso, Claudete Aparecida Araújo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vianna, Renata Artimos de Oliveira
Lovero, Kathryn Lynn
Oliveira, Solange Artimos de
Fernandes, Alexandre Ribeiro
Santos, Teresa Cristina Sarmet dos
Lima, Luiz Cláudio Santos de Souza
Carvalho, Fabiana Rabe
Quintans, Maria Dolores Salgado
Bueno, Arnaldo Costa
Torbey, Ana Flávia Malheiros
Souza, Aurea Lucia Alves Azevedo Grippa de
Farias, Armanda de Oliveira Pache de
Camacho, Luiz Antonio Bastos
Riley, Lee Woodland
Cardoso, Claudete Aparecida Araújo
dc.subject.other.pt_BR.fl_str_mv Zika Virus
Microcefalia
topic Zika Virus
Microcefalia
Congenital Zika Syndrome
RT-PCR
Zika Virus
Microcephaly
Zika Virus
Microcephaly
dc.subject.en.pt_BR.fl_str_mv Congenital Zika Syndrome
RT-PCR
Zika Virus
Microcephaly
dc.subject.decs.pt_BR.fl_str_mv Zika Virus
Microcephaly
description Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil.
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2020-06-03T14:23:15Z
dc.date.available.fl_str_mv 2020-06-03T14:23:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VIANNA, Renata A. de Oliveira et al. Children born to mothers with rash during Zika Virus Epidemic in Brazil: first 18 months of life. J. Tropical Pediatrics, v.65, n.6, p.592-602, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/41499
dc.identifier.issn.pt_BR.fl_str_mv 0142-6338
dc.identifier.doi.none.fl_str_mv 10.1093/tropej/fmz019
dc.identifier.eissn.none.fl_str_mv 1465-3664
identifier_str_mv VIANNA, Renata A. de Oliveira et al. Children born to mothers with rash during Zika Virus Epidemic in Brazil: first 18 months of life. J. Tropical Pediatrics, v.65, n.6, p.592-602, 2019.
0142-6338
10.1093/tropej/fmz019
1465-3664
url https://www.arca.fiocruz.br/handle/icict/41499
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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