Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T Cells during infection are directly associated with leve7l of circulating parasites
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/3743 |
Resumo: | Agradecemos a Michelle Groenner pela ajudar na pesquisa de campo e nas atividades de laboratório |
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Bueno, Lilian LacerdaMorais, Cristiane GuimarãesAraújo, Fernanda Fortes deGomes, Juliana de Assis SilvaOliveira, Rodrigo Corrêa deSoares, Irene da SilvaLacerda, Marcus ViníciusFujiwara, Ricardo ToshioBraga, Érika Martins2012-01-26T14:23:23Z2012-01-26T14:23:23Z2010BUENO, Lilian Lacerda et al. Plasmodium vivax: Induction of CD4+CD25+FoxP3+ Regulatory T Cells during Infection Are Directly Associated with Level of Circulating Parasites. Plos One , v. 5, p. e9623, 2010.1932-6203https://www.arca.fiocruz.br/handle/icict/3743Agradecemos a Michelle Groenner pela ajudar na pesquisa de campo e nas atividades de laboratórioEste trabalho foi financiado pela FAPEMIG.Universidade Federal de Minas Gerais. Departamento de Morfologia. Instituto de Ciências Biológicas, Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Morfologia. Instituto de Ciências Biológicas, Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Renê Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Renê Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Departamento de Morfologia. Instituto de Ciências Biológicas, Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Renê Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil.Universidade de São Paulo. Departamento de Análises Clínicas e Toxicológicas, São Paulo, SP Brasil.Fundação de Medicina Tropical do Amazonas, Manaus, Brazil.Universidade Federal de Minas Gerais. Departamento de Morfologia. Instituto de Ciências Biológicas, Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Renê Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Departamento de Morfologia. Instituto de Ciências Biológicas, Belo Horizonte, MG, Brasil.Circulation CD4+CD25+FoxP3+ regulatory T cells (Tregs) have been associated with the delicate balancing between control of overwhelming acute malaria infection and prevention of immune pathology due to disproportionate inflammatory responses to erythrocytic stage of the parasite. While the role of Tregs has been well-documented in murine models and P. falciparum infection, the phenotype and function of Tregs in P. vivax infection is still poorly characterized. In the current study, we demonstrated that patients with acute P. vivax infection presented a significant augmentation of circulating Tregs producing anti-inflammatory (IL-10 and TGF-b) as well as pro-inflammatory (IFN-c, IL-17) cytokines, which was further positively correlated with parasite burden. Surface expression of GITR molecule and intracellular expression of CTLA-4 were significantly upregulated in Tregs from infected donors, presenting also a positive association between either absolute numbers of CD4+CD25+FoxP3+GITR+ or CD4+CD25+FoxP3+CTLA-4+ and parasite load. Finally, we demonstrate a suppressive effect of Treg cells in specific T cell proliferative responses of P. vivax infected subjects after antigen stimulation with Pv- AMA-1. Our findings indicate that malaria vivax infection lead to an increased number of activated Treg cells that are highly associated with parasite load, which probably exert an important contribution to the modulation of immune responses during P. vivax infection.engPlos OnePublic Library of ScienceSociedade Brasileira de Medicina TropicalPlasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T Cells during infection are directly associated with leve7l of circulating parasitesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMaláriaPrevenção & ControleBrasilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINAL10_Plasmodium vivax Induction of CD4+CD25+FoxP3+ Regulatory T Cells during Infection Are Directly Associated with Level of Circulating Parasites.pdf10_Plasmodium vivax Induction of CD4+CD25+FoxP3+ Regulatory T Cells during Infection Are Directly Associated with Level of Circulating Parasites.pdfapplication/pdf566919https://www.arca.fiocruz.br/bitstream/icict/3743/1/10_Plasmodium%20vivax%20Induction%20of%20CD4%2bCD25%2bFoxP3%2b%20Regulatory%20T%20Cells%20during%20Infection%20Are%20Directly%20Associated%20with%20Level%20of%20Circulating%20Parasites.pdfa1f3799a643f3cf22cdc706b981b394fMD51LICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T Cells during infection are directly associated with leve7l of circulating parasites |
| title |
Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T Cells during infection are directly associated with leve7l of circulating parasites |
| spellingShingle |
Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T Cells during infection are directly associated with leve7l of circulating parasites Bueno, Lilian Lacerda Malária Prevenção & Controle Brasil |
| title_short |
Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T Cells during infection are directly associated with leve7l of circulating parasites |
| title_full |
Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T Cells during infection are directly associated with leve7l of circulating parasites |
| title_fullStr |
Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T Cells during infection are directly associated with leve7l of circulating parasites |
| title_full_unstemmed |
Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T Cells during infection are directly associated with leve7l of circulating parasites |
| title_sort |
Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T Cells during infection are directly associated with leve7l of circulating parasites |
| author |
Bueno, Lilian Lacerda |
| author_facet |
Bueno, Lilian Lacerda Morais, Cristiane Guimarães Araújo, Fernanda Fortes de Gomes, Juliana de Assis Silva Oliveira, Rodrigo Corrêa de Soares, Irene da Silva Lacerda, Marcus Vinícius Fujiwara, Ricardo Toshio Braga, Érika Martins |
| author_role |
author |
| author2 |
Morais, Cristiane Guimarães Araújo, Fernanda Fortes de Gomes, Juliana de Assis Silva Oliveira, Rodrigo Corrêa de Soares, Irene da Silva Lacerda, Marcus Vinícius Fujiwara, Ricardo Toshio Braga, Érika Martins |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bueno, Lilian Lacerda Morais, Cristiane Guimarães Araújo, Fernanda Fortes de Gomes, Juliana de Assis Silva Oliveira, Rodrigo Corrêa de Soares, Irene da Silva Lacerda, Marcus Vinícius Fujiwara, Ricardo Toshio Braga, Érika Martins |
| dc.subject.decs.pt_BR.fl_str_mv |
Malária Prevenção & Controle Brasil |
| topic |
Malária Prevenção & Controle Brasil |
| description |
Agradecemos a Michelle Groenner pela ajudar na pesquisa de campo e nas atividades de laboratório |
| publishDate |
2010 |
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2010 |
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2012-01-26T14:23:23Z |
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2012-01-26T14:23:23Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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BUENO, Lilian Lacerda et al. Plasmodium vivax: Induction of CD4+CD25+FoxP3+ Regulatory T Cells during Infection Are Directly Associated with Level of Circulating Parasites. Plos One , v. 5, p. e9623, 2010. |
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https://www.arca.fiocruz.br/handle/icict/3743 |
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1932-6203 |
| identifier_str_mv |
BUENO, Lilian Lacerda et al. Plasmodium vivax: Induction of CD4+CD25+FoxP3+ Regulatory T Cells during Infection Are Directly Associated with Level of Circulating Parasites. Plos One , v. 5, p. e9623, 2010. 1932-6203 |
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eng |
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openAccess |
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Plos One Public Library of Science Sociedade Brasileira de Medicina Tropical |
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Plos One Public Library of Science Sociedade Brasileira de Medicina Tropical |
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