Human T cell responses to Dengue and Zika virus infection compared to Dengue/Zika coinfection

Detalhes bibliográficos
Autor(a) principal: Corrêa, Jessica Badolato
Data de Publicação: 2017
Outros Autores: Sánchez-Arcila, Juan Camilo, Souza, Thiara Manuele Alves de, Barbosa, Luciana Santos, Nunes, Priscila Conrado Guerra, Lima, Monique da Rocha Queiroz, Gandini, Mariana, Filippis, Ana Maria Bispo de, Cunha, Rivaldo Venâncio da, Azeredo, Elzinandes Leal de, Pinto, Luzia Maria de Oliveira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/23923
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
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spelling Corrêa, Jessica BadolatoSánchez-Arcila, Juan CamiloSouza, Thiara Manuele Alves deBarbosa, Luciana SantosNunes, Priscila Conrado GuerraLima, Monique da Rocha QueirozGandini, MarianaFilippis, Ana Maria Bispo deCunha, Rivaldo Venâncio daAzeredo, Elzinandes Leal dePinto, Luzia Maria de Oliveira2018-01-16T13:13:40Z2018-01-16T13:13:40Z2017CORRÊA, Jessica Badolato; et al. Human T cell responses to Dengue and Zika virus infection compared to Dengue/Zika coinfection. Immunity, Inflammation and Disease, 13p, 20182050-4527https://www.arca.fiocruz.br/handle/icict/2392310.1002/iid3.203engWiley Open AccessDengueZika virusLinfócitos TDengueZika virusT lymphocytesHuman T cell responses to Dengue and Zika virus infection compared to Dengue/Zika coinfectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil / Universidade Federal do Rio de Janeiro. Instituto de Pediatria e Puericultura Martagão Gesteira. Laboratório de Genética. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil.Universidade Federal do Mato Grosso do Sul. Departamento de Clínica Médica. Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Campo Grande, MS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Introduction: Zika virus (ZIKV) and dengue virus (DENV) co-circulated during latest outbreaks in Brazil, hence, it is important to evaluate the host cross-reactive immune responses to these viruses. So far, little is known about human T cell responses to ZIKV and no reports detail adaptive immune responses during DENV/ZIKV coinfection. Methods: Here, we studied T cells responses in well-characterized groups of DENV, ZIKV, or DENV/ZIKV infected patients and DENV-exposed healthy donors. We evaluated chemokine receptors expression and single/multifunctional frequencies of IFNg, TNF, and IL2-producing T cells during these infections. Even without antigenic stimulation, it was possible to detect chemokine receptors and IFNg, TNF, and IL2-producing T cells from all individuals by flow cytometry. Additionally, PBMCs’ IFNg response to DENV NS1 protein and to polyclonal stimuli was evaluated by ELISPOT. Results: DENV and ZIKV infections and DENV/ZIKV coinfections similarly induced expression of CCR5, CX3CR1, and CXCR3 on CD4 and CD8 T cells. DENV/ZIKV coinfection decreased the ability of CD4 þ T cells to produce IFNg þ , TNF þ , TNF þ IFNg þ , and TNF þ IL2 þ , compared to DENV and ZIKV infections. A higher magnitude of IFNg response to DENV NS1 was found in donors with a history of dengue infection, however, a hyporesponsiveness was found in acute DENV, ZIKV, or DENV/ZIKV infected patients, even previously infected with DENV. Conclusion: Therefore, we emphasize the potential impact of coinfection on the immune response from human hosts, mainly in areas where DENV and ZIKV cocirculate.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23923/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjessica_correa_etal_IOC_2017.pdfjessica_correa_etal_IOC_2017.pdfapplication/pdf1263712https://www.arca.fiocruz.br/bitstream/icict/23923/2/jessica_correa_etal_IOC_2017.pdfaa31f0da03a5992f70cddbd33eb7bf7aMD52TEXTjessica_correa_etal_IOC_2017.pdf.txtjessica_correa_etal_IOC_2017.pdf.txtExtracted texttext/plain53183https://www.arca.fiocruz.br/bitstream/icict/23923/3/jessica_correa_etal_IOC_2017.pdf.txt7bca93db54ac89b3c23cc987187f299aMD53icict/239232023-09-05 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dc.title.pt_BR.fl_str_mv Human T cell responses to Dengue and Zika virus infection compared to Dengue/Zika coinfection
title Human T cell responses to Dengue and Zika virus infection compared to Dengue/Zika coinfection
spellingShingle Human T cell responses to Dengue and Zika virus infection compared to Dengue/Zika coinfection
Corrêa, Jessica Badolato
Dengue
Zika virus
Linfócitos T
Dengue
Zika virus
T lymphocytes
title_short Human T cell responses to Dengue and Zika virus infection compared to Dengue/Zika coinfection
title_full Human T cell responses to Dengue and Zika virus infection compared to Dengue/Zika coinfection
title_fullStr Human T cell responses to Dengue and Zika virus infection compared to Dengue/Zika coinfection
title_full_unstemmed Human T cell responses to Dengue and Zika virus infection compared to Dengue/Zika coinfection
title_sort Human T cell responses to Dengue and Zika virus infection compared to Dengue/Zika coinfection
author Corrêa, Jessica Badolato
author_facet Corrêa, Jessica Badolato
Sánchez-Arcila, Juan Camilo
Souza, Thiara Manuele Alves de
Barbosa, Luciana Santos
Nunes, Priscila Conrado Guerra
Lima, Monique da Rocha Queiroz
Gandini, Mariana
Filippis, Ana Maria Bispo de
Cunha, Rivaldo Venâncio da
Azeredo, Elzinandes Leal de
Pinto, Luzia Maria de Oliveira
author_role author
author2 Sánchez-Arcila, Juan Camilo
Souza, Thiara Manuele Alves de
Barbosa, Luciana Santos
Nunes, Priscila Conrado Guerra
Lima, Monique da Rocha Queiroz
Gandini, Mariana
Filippis, Ana Maria Bispo de
Cunha, Rivaldo Venâncio da
Azeredo, Elzinandes Leal de
Pinto, Luzia Maria de Oliveira
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Corrêa, Jessica Badolato
Sánchez-Arcila, Juan Camilo
Souza, Thiara Manuele Alves de
Barbosa, Luciana Santos
Nunes, Priscila Conrado Guerra
Lima, Monique da Rocha Queiroz
Gandini, Mariana
Filippis, Ana Maria Bispo de
Cunha, Rivaldo Venâncio da
Azeredo, Elzinandes Leal de
Pinto, Luzia Maria de Oliveira
dc.subject.other.pt_BR.fl_str_mv Dengue
Zika virus
Linfócitos T
topic Dengue
Zika virus
Linfócitos T
Dengue
Zika virus
T lymphocytes
dc.subject.en.pt_BR.fl_str_mv Dengue
Zika virus
T lymphocytes
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-01-16T13:13:40Z
dc.date.available.fl_str_mv 2018-01-16T13:13:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CORRÊA, Jessica Badolato; et al. Human T cell responses to Dengue and Zika virus infection compared to Dengue/Zika coinfection. Immunity, Inflammation and Disease, 13p, 2018
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/23923
dc.identifier.issn.pt_BR.fl_str_mv 2050-4527
dc.identifier.doi.none.fl_str_mv 10.1002/iid3.203
identifier_str_mv CORRÊA, Jessica Badolato; et al. Human T cell responses to Dengue and Zika virus infection compared to Dengue/Zika coinfection. Immunity, Inflammation and Disease, 13p, 2018
2050-4527
10.1002/iid3.203
url https://www.arca.fiocruz.br/handle/icict/23923
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley Open Access
publisher.none.fl_str_mv Wiley Open Access
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/23923/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/23923/2/jessica_correa_etal_IOC_2017.pdf
https://www.arca.fiocruz.br/bitstream/icict/23923/3/jessica_correa_etal_IOC_2017.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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