Accuracy of Zika virus disease case definition during simultaneous Dengue and Chikungunya epidemics

Detalhes bibliográficos
Autor(a) principal: Braga, José Ueleres
Data de Publicação: 2017
Outros Autores: Bressan, Clarisse, Dalvi, Ana Paula Razal, Calvet, Guilherme Amaral, Daumas, Regina Paiva, Rodrigues, Nadia, Wakimoto, Mayumi, Nogueira, Rita Maria Ribeiro, Nielsen-Saines, Karin, Brito, Carlos, Filippis, Ana Maria Bispo de, Brasil, Patrícia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/19690
Resumo: Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.
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spelling Braga, José UeleresBressan, ClarisseDalvi, Ana Paula RazalCalvet, Guilherme AmaralDaumas, Regina PaivaRodrigues, NadiaWakimoto, MayumiNogueira, Rita Maria RibeiroNielsen-Saines, KarinBrito, CarlosFilippis, Ana Maria Bispo deBrasil, Patrícia2017-07-04T14:40:39Z2017-07-04T14:40:39Z2017BRAGA, José Ueleres et al. Accuracy of Zika virus disease case definition during simultaneous Dengue and Chikungunya epidemics. PLoS ONE, v. 12, n. 6, p. 1-14, June 26, 2017.https://www.arca.fiocruz.br/handle/icict/1969010.1371/journal.pone.0179725engThe Public Library of Science (PLOS)Zika VirusDengueVírus ChikungunyaZika VirusDengueChikungunya VirusZika VirusDengueVírus ChikungunyaAccuracy of Zika virus disease case definition during simultaneous Dengue and Chikungunya epidemicsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência de Flavivírus. Rio de Janeiro, RJ, Brasil.David Geffen UCLA School of Medicine. Los Angeles, United States of America.Universidade Federal de Pernambuco. Departamento de Clinica Medica. Recife, Pernambuco, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Background: Zika is a new disease in the American continent and its surveillance is of utmost importance, especially because of its ability to cause neurological manifestations as Guillain-Barre syndrome and serious congenital malformations through vertical transmission. The detection of suspected cases by the surveillance system depends on the case definition adopted. As the laboratory diagnosis of Zika infection still relies on the use of expensive and complex molecular techniques with low sensitivity due to a narrow window of detection, most suspected cases are not confirmed by laboratory tests, mainly reserved for pregnant women and newborns. In this context, an accurate definition of a suspected Zika case is crucial in order for the surveillance system to gauge the magnitude of an epidemic. Methodology: We evaluated the accuracy of various Zika case definitions in a scenario where Dengue and Chikungunya viruses co-circulate. Signs and symptoms that best discriminated PCR confirmed Zika from other laboratory confirmed febrile or exanthematic diseases were identified to propose and test predictive models for Zika infection based on these clinical features. Results and discussion: Our derived score prediction model had the best performance because it demonstrated the highest sensitivity and specificity, 86_6% and 78_3%, respectively. This Zika case definition also had the highest values for auROC (0_903) and R2 (0_417), and the lowest Brier score 0_096. Conclusions: In areas where multiple arboviruses circulate, the presence of rash with pruritus or conjunctival hyperemia, without any other general clinical manifestations such as fever, petechia or anorexia is the best Zika case definition.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19690/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAccuracyZikaVirusDisease.pdfAccuracyZikaVirusDisease.pdfapplication/pdf1798607https://www.arca.fiocruz.br/bitstream/icict/19690/2/AccuracyZikaVirusDisease.pdf2bfc7352e132877c5b78d9a76c2e1a85MD52TEXTAccuracyZikaVirusDisease.pdf.txtAccuracyZikaVirusDisease.pdf.txtExtracted texttext/plain43112https://www.arca.fiocruz.br/bitstream/icict/19690/3/AccuracyZikaVirusDisease.pdf.txtd34e0f6e02eb3e3837f06a0c8b43ee88MD53icict/196902023-04-11 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dc.title.pt_BR.fl_str_mv Accuracy of Zika virus disease case definition during simultaneous Dengue and Chikungunya epidemics
title Accuracy of Zika virus disease case definition during simultaneous Dengue and Chikungunya epidemics
spellingShingle Accuracy of Zika virus disease case definition during simultaneous Dengue and Chikungunya epidemics
Braga, José Ueleres
Zika Virus
Dengue
Vírus Chikungunya
Zika Virus
Dengue
Chikungunya Virus
Zika Virus
Dengue
Vírus Chikungunya
title_short Accuracy of Zika virus disease case definition during simultaneous Dengue and Chikungunya epidemics
title_full Accuracy of Zika virus disease case definition during simultaneous Dengue and Chikungunya epidemics
title_fullStr Accuracy of Zika virus disease case definition during simultaneous Dengue and Chikungunya epidemics
title_full_unstemmed Accuracy of Zika virus disease case definition during simultaneous Dengue and Chikungunya epidemics
title_sort Accuracy of Zika virus disease case definition during simultaneous Dengue and Chikungunya epidemics
author Braga, José Ueleres
author_facet Braga, José Ueleres
Bressan, Clarisse
Dalvi, Ana Paula Razal
Calvet, Guilherme Amaral
Daumas, Regina Paiva
Rodrigues, Nadia
Wakimoto, Mayumi
Nogueira, Rita Maria Ribeiro
Nielsen-Saines, Karin
Brito, Carlos
Filippis, Ana Maria Bispo de
Brasil, Patrícia
author_role author
author2 Bressan, Clarisse
Dalvi, Ana Paula Razal
Calvet, Guilherme Amaral
Daumas, Regina Paiva
Rodrigues, Nadia
Wakimoto, Mayumi
Nogueira, Rita Maria Ribeiro
Nielsen-Saines, Karin
Brito, Carlos
Filippis, Ana Maria Bispo de
Brasil, Patrícia
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Braga, José Ueleres
Bressan, Clarisse
Dalvi, Ana Paula Razal
Calvet, Guilherme Amaral
Daumas, Regina Paiva
Rodrigues, Nadia
Wakimoto, Mayumi
Nogueira, Rita Maria Ribeiro
Nielsen-Saines, Karin
Brito, Carlos
Filippis, Ana Maria Bispo de
Brasil, Patrícia
dc.subject.other.pt_BR.fl_str_mv Zika Virus
Dengue
Vírus Chikungunya
topic Zika Virus
Dengue
Vírus Chikungunya
Zika Virus
Dengue
Chikungunya Virus
Zika Virus
Dengue
Vírus Chikungunya
dc.subject.en.pt_BR.fl_str_mv Zika Virus
Dengue
Chikungunya Virus
dc.subject.decs.pt_BR.fl_str_mv Zika Virus
Dengue
Vírus Chikungunya
description Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-07-04T14:40:39Z
dc.date.available.fl_str_mv 2017-07-04T14:40:39Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BRAGA, José Ueleres et al. Accuracy of Zika virus disease case definition during simultaneous Dengue and Chikungunya epidemics. PLoS ONE, v. 12, n. 6, p. 1-14, June 26, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/19690
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0179725
identifier_str_mv BRAGA, José Ueleres et al. Accuracy of Zika virus disease case definition during simultaneous Dengue and Chikungunya epidemics. PLoS ONE, v. 12, n. 6, p. 1-14, June 26, 2017.
10.1371/journal.pone.0179725
url https://www.arca.fiocruz.br/handle/icict/19690
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv The Public Library of Science (PLOS)
publisher.none.fl_str_mv The Public Library of Science (PLOS)
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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