Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllers
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20039 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil. |
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Azevedo, Suwellen S. D. deCaetano, Diogo GamaCôrtes, Fernanda H.Teixeira, Sylvia L. M.Silva, Karina dos SantosHoagland, Brenda Regina de SiqueiraGrinsztejn, BeatrizVeloso, Valdiléa G.Morgado, Mariza G.Bello, Gonzalo2017-07-11T15:20:28Z2017-07-11T15:20:28Z2017AZEVEDO, Suwellen S. D. de et al. Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllers. Retrovirology, v. 14, p. 1-13, 2017.1742-4690https://www.arca.fiocruz.br/handle/icict/2003910.1186/s12977-017-0354-5engBioMed CentralHIV-1DiversidadeEvoluçãoReservatórioControle de viremiaHIV-1Elite controllersViremic controllersReservoirDiversityEvolutionReseedingHighly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllersinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Ongoing intra-host HIV-1 evolution has been shown in individuals that naturally suppress the viremia to low levels (HIV controllers) by the analysis of the RNA in plasma compartment. Detection of evolution at the DNA proviral compartment in HIV controllers, however, has been more challenging and the precise correlation between the systemic viral suppression level and rate of reservoir's reseeding in those individuals is not fully understood. In this sense, we examined the proviral DNA quasispecies by single genome amplification of the env gene in a cohort of 23 HIV controllers from Brazil, divided in three groups, according to the level of systemic viral suppression: (1) elite controllers with persistent undetectable viral load (PEC, n = 6); (2) elite controllers with occasional episodes of transient (51-400 copies/mL) viremia (EEC, n = 7); and (3) viremic controllers with persistent low-level (80-2000 copies/mL) viremia (VC, n = 10).info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllers |
| title |
Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllers |
| spellingShingle |
Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllers Azevedo, Suwellen S. D. de HIV-1 Diversidade Evolução Reservatório Controle de viremia HIV-1 Elite controllers Viremic controllers Reservoir Diversity Evolution Reseeding |
| title_short |
Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllers |
| title_full |
Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllers |
| title_fullStr |
Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllers |
| title_full_unstemmed |
Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllers |
| title_sort |
Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllers |
| author |
Azevedo, Suwellen S. D. de |
| author_facet |
Azevedo, Suwellen S. D. de Caetano, Diogo Gama Côrtes, Fernanda H. Teixeira, Sylvia L. M. Silva, Karina dos Santos Hoagland, Brenda Regina de Siqueira Grinsztejn, Beatriz Veloso, Valdiléa G. Morgado, Mariza G. Bello, Gonzalo |
| author_role |
author |
| author2 |
Caetano, Diogo Gama Côrtes, Fernanda H. Teixeira, Sylvia L. M. Silva, Karina dos Santos Hoagland, Brenda Regina de Siqueira Grinsztejn, Beatriz Veloso, Valdiléa G. Morgado, Mariza G. Bello, Gonzalo |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Azevedo, Suwellen S. D. de Caetano, Diogo Gama Côrtes, Fernanda H. Teixeira, Sylvia L. M. Silva, Karina dos Santos Hoagland, Brenda Regina de Siqueira Grinsztejn, Beatriz Veloso, Valdiléa G. Morgado, Mariza G. Bello, Gonzalo |
| dc.subject.other.pt_BR.fl_str_mv |
HIV-1 Diversidade Evolução Reservatório Controle de viremia |
| topic |
HIV-1 Diversidade Evolução Reservatório Controle de viremia HIV-1 Elite controllers Viremic controllers Reservoir Diversity Evolution Reseeding |
| dc.subject.en.pt_BR.fl_str_mv |
HIV-1 Elite controllers Viremic controllers Reservoir Diversity Evolution Reseeding |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil. |
| publishDate |
2017 |
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2017-07-11T15:20:28Z |
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2017-07-11T15:20:28Z |
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2017 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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AZEVEDO, Suwellen S. D. de et al. Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllers. Retrovirology, v. 14, p. 1-13, 2017. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/20039 |
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1742-4690 |
| dc.identifier.doi.none.fl_str_mv |
10.1186/s12977-017-0354-5 |
| identifier_str_mv |
AZEVEDO, Suwellen S. D. de et al. Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllers. Retrovirology, v. 14, p. 1-13, 2017. 1742-4690 10.1186/s12977-017-0354-5 |
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BioMed Central |
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BioMed Central |
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